Naturally Occurring Antifungal Agents againstZygosaccharomyces bailiiand Their Synergism

2005 ◽  
Vol 53 (13) ◽  
pp. 5187-5191 ◽  
Author(s):  
Ken-Ichi Fujita ◽  
Isao Kubo
Keyword(s):  
Antifungal Agents ◽  
Naturally Occurring

Interactions between naturally occurring antifungal agents

2013 ◽  
Vol 64 (4) ◽  
pp. 510-512 ◽  
Author(s):  
Viktória Tóth ◽  
Melinda Szilágyi ◽  
Fruzsina Anton ◽  
Éva Leiter ◽  
I. Pócsi ◽  
...  
Keyword(s):  
Antifungal Agents ◽  
Naturally Occurring

A Comprehensive Review: Bio-Potential of Barbituric Acid and its Analogues

2020 ◽  
Vol 24 (2) ◽  
pp. 129-161
Author(s):  
Nusrat Shafiq ◽  
Uzma Arshad ◽  
Gul Zarren ◽  
Shagufta Parveen ◽  
Irum Javed ◽  
...  
Keyword(s):  
Barbituric Acid ◽  
Antifungal Agents ◽  
Single Point ◽  
Building Blocks ◽  
Specific Aspect ◽  
Medicinal Uses ◽  
Naturally Occurring ◽  
Wide Range ◽  
History Of ◽  
Bioactive Agents

In our present work, we emphasized on the potential of barbituric acid (1) derivatives as drugs like anti-bacterial, hypnotic, sedative, anti-microbial and antifungal agents. As naturally occurring, barbituric acid (1) is inactive but in the derivative form, it has a large number of medicinal uses and nowadays, it has a great demand in the pharmaceutical industry. Barbituric acid has a wide range of applications in the synthesis of a diverse class of compounds like heterocyclic, carbocyclic, synthetic alkaloids, and due to its broad-spectrum applications, barbituric acid acquired the position of building blocks in synthetic chemistry. Through the history of humanity, a number of bioactive agents have been applied to cure the disease related to hypnotics and sedatives, while the exact efficacy of these agents was found to be limited. Till now, review articles on barbituric acid only express their specific aspect but in present review article, all aspects are discussed in detail to provide a platform to readers and researchers so that they could obtain all information and background knowledge from a single point.

An Overview on Pyranocoumarins: Synthesis and Biological Activities

2020 ◽  
Vol 23 (24) ◽  
pp. 2679-2721 ◽  
Author(s):  
Evangelia-Eirini N. Vlachou ◽  
Konstantinos E. Litinas
Keyword(s):  
Organic Compounds ◽  
Antifungal Agents ◽  
Biological Activities ◽  
Biological Properties ◽  
Pyran Ring ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Antibacterial And Antifungal ◽  
Anti Hiv

Pyrano- and dipyranocoumarins are classes of naturally occurring organic compounds with very interesting biological activities. This review focuses on the synthetic strategies for the synthesis of pyranocoumarins and dipyranocoumarins and the biological properties of those compounds. The synthesis involves the formation of the pyran ring, at first, from a coumarin or the formation of pyranone moiety from an existing pyran. Pyranocoumarins and dipyranocoumarins present anti-HIV, anti-cancer, neuroprotective, antidiabetic, antibacterial, antifungal, anti-inflammatory activities. Especially khellactones and calanolides are usually potent and selective in anti-HIV activity. Decursin and decursinol derivatives are effective as anticancer, neuroprotective, antidiabetic, antibacterial, and antifungal agents.

scholarly journals Modifications of PARP Medium Using Fluazinam, Miconazole, and Nystatin for Detection of Pythium spp. in Soil

Plant Disease ◽  
2007 ◽  
Vol 91 (12) ◽  
pp. 1591-1599 ◽  
Author(s):  
Y. Morita ◽  
M. Tojo
Keyword(s):  
New Media ◽  
Fusarium Oxysporum ◽  
Mycelial Growth ◽  
Antifungal Agents ◽  
Selective Medium ◽  
Plating Technique ◽  
Naturally Occurring ◽  
Different Types ◽  
Soil Dilution ◽  
Better Than

The standard Pythium selective medium PARP (pimaricin + ampicillin + rifampicin + pentachloronitrobenzene [PCNB] agar), was modified by replacing PCNB and pimaricin with other antifungal agents. Several antifungal agents such as fluazinam, miconazole, 2,4,5,6-tetrachloroisophthalonitrile (TPN), iminoctadine triacetate, tolclofos-methyl, captan, and nystatin, initially were screened for effects on Pythium growth. Based on these results, the following three media were developed: PARF (pimaricin + ampicillin + rifampicin + fluazinam agar), NARF (nystatin + ampicillin + rifampicin + fluazinam agar), and NARM (nystatin + ampicillin + rifampicin + miconazole agar). New media were comparable with PARP on yield of naturally occurring Pythium spp. from two different types of soil using the soil-dilution plating technique. PARF and NARF were significantly better than PARP on inhibition of non-pythiaceous microbes on the soil-dilution plates, but were significantly lower than PARP on the rate of mycelial growth of six of eight isolates belonging to seven species of Pythium. NARM was equivalent to PARP on inhibition of non-pythiaceous microbes except for Fusarium oxysporum, and was significantly better than PARP on rate of mycelial growth of five of eight isolates of Pythium.

Natural Products, for Fungal Diseases Management and Prevention

2021 ◽  
Vol 11 ◽  
Author(s):  
Nahid Akhtar ◽  
Rabia Ayoubi ◽  
Vinaypreet Kour ◽  
Umesh Goutam ◽  
M. Amin-ul Mannan
Keyword(s):  
Public Health ◽  
Side Effects ◽  
Antifungal Agents ◽  
Fungal Species ◽  
Antifungal Drugs ◽  
Fungal Diseases ◽  
Naturally Occurring ◽  
Invasive Fungal Diseases ◽  
Emergence Of Resistance

Abstract: Fungal diseases cause more deaths as compared to combined deaths due to malaria and tuberculosis. There are around 3.8 million fungal species, but only about 300 of them are pathogenic to humans. Invasive fungal diseases are majorly caused by Aspergillus, Candida, Cryptococcus, Histoplasma, Mucorales, and Pneumocystis. It has been estimated that around 1.5 million people die because of these infections across the globe. The emergence of resistance against the major classes of antifungal drugs poses a serious threat to public health. Moreover, the commonly used antifungal drugs are loaded with side effects. Some of them are nephrotoxic, hepatotoxic, cause cardiomyopathy, and in acute cases, cytotoxicity. Hence, it is important to seek novel molecules that can be safe and effective antifungal drugs. Naturally occurring molecules in plants and various microorganisms can be a safe and effective alternative to the existing antifungal drugs. In this review, the role of various phytochemicals such as alkaloids, flavonoids, saponins, and phenols as potential antifungal agents has been discussed. Similarly, naturally occurring molecules in other microorganisms like algae, bacteria, and various other fungi have been summarized. The information discussed in this review can be useful in the identification of novel antifungals.

Pathology of Bone Cells in Pigs with Experimental Turbinate Osteoporosis (Atrophic Rhinitis)

1971 ◽  
Vol 29 ◽  
pp. 304-305
Author(s):  
A. W. Fetter ◽  
C. C. Capen
Keyword(s):  
Mucous Membrane ◽  
Bone Cells ◽  
Atrophic Rhinitis ◽  
Infectious Agents ◽  
Metabolic Disturbances ◽  
Progressive Reduction ◽  
Naturally Occurring ◽  
Fundamental Cause ◽  
Osteocytic Osteolysis ◽  
Uncertain Etiology

Atrophic rhinitis in swine is a disease of uncertain etiology in which infectious agents, hereditary predisposition, and metabolic disturbances have been reported to be of primary etiologic importance. It shares many similarities, both clinically and pathologically, with ozena in man. The disease is characterized by deformity and reduction in volume of the nasal turbinates. The fundamental cause for the localized lesion of bone in the nasal turbinates has not been established. Reduced osteogenesis, increased resorption related to inflammation of the nasal mucous membrane, and excessive resorption due to osteocytic osteolysis stimulated by hyperparathyroidism have been suggested as possible pathogenetic mechanisms.The objectives of this investigation were to evaluate ultrastructurally bone cells in the nasal turbinates of pigs with experimentally induced atrophic rhinitis, and to compare these findings to those in control pigs of the same age and pigs with the naturally occurring disease, in order to define the fundamental lesion responsible for the progressive reduction in volume of the osseous core.

High Resolution Replication of Organoclay Surfaces

1982 ◽  
Vol 40 ◽  
pp. 576-577
Author(s):  
W. W. Barker ◽  
W. E. Rigsby ◽  
V. J. Hurst ◽  
W. J. Humphreys
Keyword(s):  
Clay Mineral ◽  
Organic Molecule ◽  
Organic Molecules ◽  
X Ray Diffraction ◽  
Xrd Pattern ◽  
X Ray ◽  
Naturally Occurring ◽  
Silicate Layers ◽  
Mineral Identification

Experimental clay mineral-organic molecule complexes long have been known and some of them have been extensively studied by X-ray diffraction methods. The organic molecules are adsorbed onto the surfaces of the clay minerals, or intercalated between the silicate layers. Natural organo-clays also are widely recognized but generally have not been well characterized. Widely used techniques for clay mineral identification involve treatment of the sample with H2 O2 or other oxidant to destroy any associated organics. This generally simplifies and intensifies the XRD pattern of the clay residue, but helps little with the characterization of the original organoclay. Adequate techniques for the direct observation of synthetic and naturally occurring organoclays are yet to be developed.

SEM study of the morphological effects of kinetin and zeatin on the growth and development of the apical meristem in wheat

1995 ◽  
Vol 53 ◽  
pp. 978-979
Author(s):  
G. M. Hutchins ◽  
J. S. Gardner
Keyword(s):  
Growth And Development ◽  
Furfuryl Alcohol ◽  
Apical Meristem ◽  
Plant Cells ◽  
Triticum Aestivum L ◽  
Morphological Development ◽  
Naturally Occurring ◽  
Chinese Spring Wheat ◽  
Sem Study ◽  
Moist Environment

Cytokinins are plant hormones that play a large and incompletely understood role in the life-cycle of plants. The goal of this study was to determine what roles cytokinins play in the morphological development of wheat. To achieve any real success in altering the development and growth of wheat, the cytokinins must be applied directly to the apical meristem, or spike of the plant. It is in this region that the plant cells are actively undergoing mitosis. Kinetin and Zeatin were the two cytokinins chosen for this experiment. Kinetin is an artificial hormone that was originally extracted from old or heated DNA. Kinetin is easily made from the reaction of adenine and furfuryl alcohol. Zeatin is a naturally occurring hormone found in corn, wheat, and many other plants.Chinese Spring Wheat (Triticum aestivum L.) was used for this experiment. Prior to planting, the seeds were germinated in a moist environment for 72 hours.

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