scholarly journals Expression and Function of CCL17 in Atopic Dermatitis

10.5772/25704 ◽  
2012 ◽  
Author(s):  
Susanne Stutte ◽  
Nancy Gerbitzki ◽  
Natalija Novak ◽  
Irmgard Frster
Keyword(s):  
Atopic Dermatitis ◽  
And Function

scholarly journals Congenital Deficiency of Conventional Dendritic Cells Promotes the Development of Atopic Dermatitis-Like Inflammation

2021 ◽  
Vol 12 ◽  
Author(s):  
Yotaro Nishikawa ◽  
Tomohiro Fukaya ◽  
Takehito Fukui ◽  
Tomofumi Uto ◽  
Hideaki Takagi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Atopic Dermatitis ◽  
Immune Responses ◽  
Skin Barrier ◽  
Lymphoid Cells ◽  
Congenital Deficiency ◽  
T Cell Immune Responses ◽  
Group 2 ◽  
And Function ◽  
The Impact

Atopic dermatitis (AD) is a common pruritic inflammatory skin disease characterized by impaired epidermal barrier function and dysregulation of Thelper-2 (TH2)-biased immune responses. While the lineage of conventional dendritic cells (cDCs) are implicated to play decisive roles in T-cell immune responses, their requirement for the development of AD remains elusive. Here, we describe the impact of the constitutive loss of cDCs on the progression of AD-like inflammation by using binary transgenic (Tg) mice that constitutively lacked CD11chi cDCs. Unexpectedly, the congenital deficiency of cDCs not only exacerbates the pathogenesis of AD-like inflammation but also elicits immune abnormalities with the increased composition and function of granulocytes and group 2 innate lymphoid cells (ILC2) as well as B cells possibly mediated through the breakdown of the Fms-related tyrosine kinase 3 ligand (Flt3L)-mediated homeostatic feedback loop. Furthermore, the constitutive loss of cDCs accelerates skin colonization of Staphylococcus aureus (S. aureus), that associated with disease flare. Thus, cDCs maintains immune homeostasis to prevent the occurrence of immune abnormalities to maintain the functional skin barrier for mitigating AD flare.

scholarly journals Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis

2020 ◽  
Vol 21 (8) ◽  
pp. 2867 ◽  
Author(s):  
Gabsik Yang ◽  
Jin Kyung Seok ◽  
Han Chang Kang ◽  
Yong-Yeon Cho ◽  
Hye Suk Lee ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Systemic Disease ◽  
Skin Barrier ◽  
Immune Dysregulation ◽  
Food Allergies ◽  
Atopic Diseases ◽  
Barrier Dysfunction ◽  
Underlying Mechanisms ◽  
Chronic Pruritus ◽  
And Function

Atopic dermatitis (AD) is a common and relapsing skin disease that is characterized by skin barrier dysfunction, inflammation, and chronic pruritus. While AD was previously thought to occur primarily in children, increasing evidence suggests that AD is more common in adults than previously assumed. Accumulating evidence from experimental, genetic, and clinical studies indicates that AD expression is a precondition for the later development of other atopic diseases, such as asthma, food allergies, and allergic rhinitis. Although the exact mechanisms of the disease pathogenesis remain unclear, it is evident that both cutaneous barrier dysfunction and immune dysregulation are critical etiologies of AD pathology. This review explores recent findings on AD and the possible underlying mechanisms involved in its pathogenesis, which is characterized by dysregulation of immunological and skin barrier integrity and function, supporting the idea that AD is a systemic disease. These findings provide further insights for therapeutic developments aiming to repair the skin barrier and decrease inflammation.

Update on the Structure and Function of the Skin Barrier: Atopic Dermatitis as an Exemplar of Clinical Implications

2013 ◽  
Vol 32 (2S) ◽  
pp. S21-S24 ◽  
Author(s):  
Peter Elias ◽  
Lawrence Eichenfield ◽  
Joseph Fowler ◽  
Paul Horowitz ◽  
Renee McLeod
Keyword(s):  
Atopic Dermatitis ◽  
Skin Barrier ◽  
Structure And Function ◽  
Clinical Implications ◽  
And Function

Mannan-Binding Lectin Levels and Function are Normal in Atopic Dermatitis Subjects with a History of Eczema Herpeticum

2009 ◽  
Vol 123 (2) ◽  
pp. S36-S36
Author(s):  
K.W. Bundy ◽  
L. McGirt ◽  
A. De Benedetto ◽  
L. Bankova ◽  
A. Wollenberg ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Eczema Herpeticum ◽  
History Of ◽  
And Function ◽  
Mannan Binding Lectin ◽  
Binding Lectin

Impaired NLRP3 inflammasome expression and function in atopic dermatitis due to Th2 milieu

Allergy ◽  
2014 ◽  
Vol 69 (8) ◽  
pp. 1058-1067 ◽  
Author(s):  
M. Niebuhr ◽  
K. Baumert ◽  
A. Heratizadeh ◽  
I. Satzger ◽  
T. Werfel
Keyword(s):  
Atopic Dermatitis ◽  
Nlrp3 Inflammasome ◽  
And Function

scholarly journals Expression and Function of CD43 and CDw60 on T Cells from Patients with Atopic Dermatitis

2001 ◽  
Vol 81 (4) ◽  
pp. 263-267 ◽  
Author(s):  
Naoyuki Higashi ◽  
Kaida Wu ◽  
Christian Grønhøj Larsen ◽  
Seiji Kawana ◽  
Kristian Thestrup-Pedersen ◽  
...  
Keyword(s):  
T Cells ◽  
Atopic Dermatitis ◽  
And Function
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