scholarly journals Immunological Basis of Membranous Glomerulonephritis

10.5772/21854 ◽  
2011 ◽  
Author(s):  
Gian Marco ◽  
Corrado Murtas ◽  
Maria Luisa ◽  
Giovanni Candiano ◽  
Maurizio Bruschi ◽  
...  
Keyword(s):  
Membranous Glomerulonephritis

Membranous glomerulonephritis - gender-related differences of disease course and evaluation of therapy efficiency

2019 ◽  
Vol 21 (1) ◽  
pp. 40-48
Author(s):  
Nevena Guerguinova ◽  
◽  
Boris Bogov ◽  
Milena Nikolova ◽  
Mila Liubomirova ◽  
...  
Keyword(s):  
Membranous Glomerulonephritis ◽  
Disease Course

scholarly journals CD73 Overexpression in Podocytes: A Novel Marker of Podocyte Injury in Human Kidney Disease

2021 ◽  
Vol 22 (14) ◽  
pp. 7642
Author(s):  
Zoran V. Popovic ◽  
Felix Bestvater ◽  
Damir Krunic ◽  
Bernhard K. Krämer ◽  
Raoul Bergner ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Kidney Diseases ◽  
Kidney Injury ◽  
Membranous Glomerulonephritis ◽  
Human Kidney ◽  
Protective Role ◽  
Control Group ◽  
Podocyte Injury ◽  
Ccr2 Expression ◽  
Cd73 Expression

The CD73 pathway is an important anti-inflammatory mechanism in various disease settings. Observations in mouse models suggested that CD73 might have a protective role in kidney damage; however, no direct evidence of its role in human kidney disease has been described to date. Here, we hypothesized that podocyte injury in human kidney diseases alters CD73 expression that may facilitate the diagnosis of podocytopathies. We assessed the expression of CD73 and one of its functionally important targets, the C-C chemokine receptor type 2 (CCR2), in podocytes from kidney biopsies of 39 patients with podocytopathy (including focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), membranous glomerulonephritis (MGN) and amyloidosis) and a control group. Podocyte CD73 expression in each of the disease groups was significantly increased in comparison to controls (p < 0.001–p < 0.0001). Moreover, there was a marked negative correlation between CD73 and CCR2 expression, as confirmed by immunohistochemistry and immunofluorescence (Pearson r = −0.5068, p = 0.0031; Pearson r = −0.4705, p = 0.0313, respectively), thus suggesting a protective role of CD73 in kidney injury. Finally, we identify CD73 as a novel potential diagnostic marker of human podocytopathies, particularly of MCD that has been notorious for the lack of pathological features recognizable by light microscopy and immunohistochemistry.

Systemic lupus erythematosus with membranous glomerulonephritis and uterine vasculitis

1997 ◽  
Vol 29 (2) ◽  
pp. 277-279 ◽  
Author(s):  
Sandro Feriozzi ◽  
Andrea Onetti Muda ◽  
Mostafa Amini ◽  
Tullio Faraggiana ◽  
Enzo Ancarani
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Membranous Glomerulonephritis ◽  
Systemic Lupus

Our case with IgA deficiency and membranous glomerulonephritis

2005 ◽  
Vol 21 (1) ◽  
pp. 132-132 ◽  
Author(s):  
Yukihiko Kawasaki ◽  
Mitsuaki Hosoya ◽  
Hitoshi Suzuki
Keyword(s):  
Membranous Glomerulonephritis ◽  
Iga Deficiency

Successful treatment of refractory adult still’s disease and membranous glomerulonephritis with infliximab

2010 ◽  
Vol 29 (4) ◽  
pp. 423-426 ◽  
Author(s):  
Taner Babacan ◽  
Ahmet Mesut Onat ◽  
Yavuz Pehlivan ◽  
Gazi Comez ◽  
Metin Karakök
Keyword(s):  
Successful Treatment ◽  
Membranous Glomerulonephritis ◽  
Still’S Disease ◽  
Still's Disease ◽  
Adult Still's Disease

scholarly journals Renal Artery Thrombosis in a Patient with Membranous Glomerulonephritis.

1992 ◽  
Vol 31 (2) ◽  
pp. 294-297 ◽  
Author(s):  
Toshiaki SHIBASAKI ◽  
Fumio ISHIMOTO ◽  
Kazuya KODAMA ◽  
Iwao OHNO ◽  
Osamu SAKAI
Keyword(s):  
Renal Artery ◽  
Membranous Glomerulonephritis ◽  
Renal Artery Thrombosis ◽  
Artery Thrombosis
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