Membranous Glomerulonephritis

2020 ◽  
Author(s):  
2019 ◽  
Vol 21 (1) ◽  
pp. 40-48
Author(s):  
Nevena Guerguinova ◽  
◽  
Boris Bogov ◽  
Milena Nikolova ◽  
Mila Liubomirova ◽  
...  

2021 ◽  
Vol 22 (14) ◽  
pp. 7642
Author(s):  
Zoran V. Popovic ◽  
Felix Bestvater ◽  
Damir Krunic ◽  
Bernhard K. Krämer ◽  
Raoul Bergner ◽  
...  

The CD73 pathway is an important anti-inflammatory mechanism in various disease settings. Observations in mouse models suggested that CD73 might have a protective role in kidney damage; however, no direct evidence of its role in human kidney disease has been described to date. Here, we hypothesized that podocyte injury in human kidney diseases alters CD73 expression that may facilitate the diagnosis of podocytopathies. We assessed the expression of CD73 and one of its functionally important targets, the C-C chemokine receptor type 2 (CCR2), in podocytes from kidney biopsies of 39 patients with podocytopathy (including focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), membranous glomerulonephritis (MGN) and amyloidosis) and a control group. Podocyte CD73 expression in each of the disease groups was significantly increased in comparison to controls (p < 0.001–p < 0.0001). Moreover, there was a marked negative correlation between CD73 and CCR2 expression, as confirmed by immunohistochemistry and immunofluorescence (Pearson r = −0.5068, p = 0.0031; Pearson r = −0.4705, p = 0.0313, respectively), thus suggesting a protective role of CD73 in kidney injury. Finally, we identify CD73 as a novel potential diagnostic marker of human podocytopathies, particularly of MCD that has been notorious for the lack of pathological features recognizable by light microscopy and immunohistochemistry.


1997 ◽  
Vol 29 (2) ◽  
pp. 277-279 ◽  
Author(s):  
Sandro Feriozzi ◽  
Andrea Onetti Muda ◽  
Mostafa Amini ◽  
Tullio Faraggiana ◽  
Enzo Ancarani

2005 ◽  
Vol 21 (1) ◽  
pp. 132-132 ◽  
Author(s):  
Yukihiko Kawasaki ◽  
Mitsuaki Hosoya ◽  
Hitoshi Suzuki

2010 ◽  
Vol 29 (4) ◽  
pp. 423-426 ◽  
Author(s):  
Taner Babacan ◽  
Ahmet Mesut Onat ◽  
Yavuz Pehlivan ◽  
Gazi Comez ◽  
Metin Karakök

1992 ◽  
Vol 31 (2) ◽  
pp. 294-297 ◽  
Author(s):  
Toshiaki SHIBASAKI ◽  
Fumio ISHIMOTO ◽  
Kazuya KODAMA ◽  
Iwao OHNO ◽  
Osamu SAKAI

2008 ◽  
Vol 121 (1-2) ◽  
pp. 34-43 ◽  
Author(s):  
Ma Ángeles Jiménez ◽  
Belén Sánchez ◽  
Ma Dolores Pérez Alenza ◽  
Pilar García ◽  
Jose Vicente López ◽  
...  

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