scholarly journals Gene Therapy for Therapeutic Angiogenesis

10.5772/21127 ◽  
2011 ◽  
Author(s):  
Rudolf Kirchmair
Keyword(s):  
Gene Therapy ◽  
Therapeutic Angiogenesis

Arterial Gene Therapy for Therapeutic Angiogenesis in Patients With Peripheral Artery Disease

Circulation ◽  
1995 ◽  
Vol 91 (11) ◽  
pp. 2687-2692 ◽  
Author(s):  
Jeffrey M. Isner ◽  
Kenneth Walsh ◽  
James Symes ◽  
Ann Pieczek ◽  
Satoshi Takeshita ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Peripheral Artery Disease ◽  
Therapeutic Angiogenesis ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals Growth factor-induced therapeutic angiogenesis and arteriogenesis in the heart?gene therapy

2005 ◽  
Vol 65 (3) ◽  
pp. 656-664 ◽  
Author(s):  
J MARKKANEN ◽  
T RISSANEN ◽  
A KIVELA ◽  
S YLAHERTTUALA
Keyword(s):  
Gene Therapy ◽  
Growth Factor ◽  
Therapeutic Angiogenesis

scholarly journals VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond

Gene Therapy ◽  
2012 ◽  
Vol 19 (6) ◽  
pp. 622-629 ◽  
Author(s):  
M Giacca ◽  
S Zacchigna
Keyword(s):  
Gene Therapy ◽  
Therapeutic Angiogenesis ◽  
Vegf Gene

Gene therapy for critical limb ischemia: Per aspera ad astra

2021 ◽  
Vol 21 ◽  
Author(s):  
Vyacheslav Z. Tarantul ◽  
Alexander V. Gavrilenko
Keyword(s):  
Gene Therapy ◽  
Critical Limb Ischemia ◽  
Viral Vectors ◽  
Ex Vivo ◽  
Single Gene ◽  
Public Health Problem ◽  
Limb Ischemia ◽  
Therapeutic Angiogenesis ◽  
Effective Treatment Option

: Peripheral artery diseases remain a serious public health problem. Although there are many traditional methods for their treatment using conservative therapeutic techniques and surgery, gene therapy is an alternative and potentially more effective treatment option especially for “no option” patients. This review treats the results of many years of research and application of gene therapy as an example of treatment of patients with critical limb ischemia. Data on successful and unsuccessful attempts to use this technology for treating this disease are presented. Trends in changing the paradigm of approaches to therapeutic angiogenesis are noted: from viral vectors to non-viral vectors, from gene transfer to the whole organism to targeted transfer to cells and tissues, from single gene use to combination of genes; from DNA therapy to RNA therapy, from in vivo therapy to ex vivo therapy.

scholarly journals Therapeutic Angiogenesis by Gene Therapy for Critical Limb Ischemia: Choice of Biological Agent

2014 ◽  
Vol 14 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Fumihiro Sanada ◽  
Yoshiaki Taniyama ◽  
Junya Azuma ◽  
Ikeda-Iwabe Yuka ◽  
Yasuhiro Kanbara ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Therapeutic Angiogenesis ◽  
Biological Agent

Therapeutic angiogenesis for peripheral artery disease: Gene therapy

VASA ◽  
2007 ◽  
Vol 36 (3) ◽  
pp. 165-173 ◽  
Author(s):  
Nikol
Keyword(s):  
Gene Therapy ◽  
Peripheral Artery Disease ◽  
Animal Experiments ◽  
Therapeutic Angiogenesis ◽  
Phase Iii ◽  
Peripheral Artery ◽  
Prevalent Disease ◽  
Advanced Stages ◽  
Artery Disease ◽  
Novel Strategy

Peripheral artery disease is a highly prevalent disease which is characterised by a high unmet medical need particularly in the more advanced stages of disease. Recent advances in the knowledge of the complex regulation of angiogenesis and arteriogenesis and ways to its induction offer hope for a novel strategy that is based on the generation of such new vessels. This strategy termed "therapeutic angiogenesis" is a concept based on the use of angiogenic factors or stem cells or their combination to promote neovascularisation for the treatment of ischaemic tissues. This article reviews both regulation of angiogenesis and the development of therapeutic strategies based on this knowledge using gene therapy. This includes knowledge from animal experiments as well as from phase I and phase II clinical trials. This information may be particularly important at a time when angiogenesis gene therapy enters the stage of phase III clinical testing hopefully leading to the first time approval of this completely new class of drug in the near future. Following articles of this series will review therapeutic angiogenesis approaches based on cytokine therapy and stem cell therapy.

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