scholarly journals VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond

Gene Therapy ◽  
2012 ◽  
Vol 19 (6) ◽  
pp. 622-629 ◽  
Author(s):  
M Giacca ◽  
S Zacchigna
Keyword(s):  
Gene Therapy ◽  
Therapeutic Angiogenesis ◽  
Vegf Gene

Arterial Gene Therapy for Therapeutic Angiogenesis in Patients With Peripheral Artery Disease

Circulation ◽  
1995 ◽  
Vol 91 (11) ◽  
pp. 2687-2692 ◽  
Author(s):  
Jeffrey M. Isner ◽  
Kenneth Walsh ◽  
James Symes ◽  
Ann Pieczek ◽  
Satoshi Takeshita ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Peripheral Artery Disease ◽  
Therapeutic Angiogenesis ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals Growth factor-induced therapeutic angiogenesis and arteriogenesis in the heart?gene therapy

2005 ◽  
Vol 65 (3) ◽  
pp. 656-664 ◽  
Author(s):  
J MARKKANEN ◽  
T RISSANEN ◽  
A KIVELA ◽  
S YLAHERTTUALA
Keyword(s):  
Gene Therapy ◽  
Growth Factor ◽  
Therapeutic Angiogenesis

scholarly journals VEGF Gene Therapy Fails to Improve Perfusion of Ischemic Myocardium in Patients With Advanced Coronary Disease: Results of the NORTHERN Trial

2009 ◽  
Vol 17 (6) ◽  
pp. 1109-1115 ◽  
Author(s):  
Duncan J Stewart ◽  
Michael JB Kutryk ◽  
David Fitchett ◽  
Michael Freeman ◽  
Nancy Camack ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Coronary Disease ◽  
Ischemic Myocardium ◽  
Vegf Gene

Percutaneous transendocardial VEGF gene therapy: MRI guided delivery and characterization of 3D myocardial strain

2010 ◽  
Vol 143 (3) ◽  
pp. 255-263 ◽  
Author(s):  
Demetrius Dicks ◽  
David Saloner ◽  
Alastair Martin ◽  
Marcus Carlsson ◽  
Maythem Saeed
Keyword(s):  
Gene Therapy ◽  
Myocardial Strain ◽  
Vegf Gene ◽  
Mri Guided

10:00: Plasmid VEGF Gene Therapy Enhances Survival of Rat Fascial

2007 ◽  
Vol 137 (2_suppl) ◽  
pp. P76-P76
Author(s):  
David B. Horn ◽  
John S. Rhee ◽  
Colin McNight ◽  
Mark K Wax ◽  
Xi Gong ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Vegf Gene

Gene therapy for critical limb ischemia: Per aspera ad astra

2021 ◽  
Vol 21 ◽  
Author(s):  
Vyacheslav Z. Tarantul ◽  
Alexander V. Gavrilenko
Keyword(s):  
Gene Therapy ◽  
Critical Limb Ischemia ◽  
Viral Vectors ◽  
Ex Vivo ◽  
Single Gene ◽  
Public Health Problem ◽  
Limb Ischemia ◽  
Therapeutic Angiogenesis ◽  
Effective Treatment Option

: Peripheral artery diseases remain a serious public health problem. Although there are many traditional methods for their treatment using conservative therapeutic techniques and surgery, gene therapy is an alternative and potentially more effective treatment option especially for “no option” patients. This review treats the results of many years of research and application of gene therapy as an example of treatment of patients with critical limb ischemia. Data on successful and unsuccessful attempts to use this technology for treating this disease are presented. Trends in changing the paradigm of approaches to therapeutic angiogenesis are noted: from viral vectors to non-viral vectors, from gene transfer to the whole organism to targeted transfer to cells and tissues, from single gene use to combination of genes; from DNA therapy to RNA therapy, from in vivo therapy to ex vivo therapy.

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