scholarly journals Inhibition of DNA Polymerase λ, a DNA Repair Enzyme, and Anti-Inflammation: Chemical Knockout Analysis for DNA Polymerase λ Using Curcumin Derivatives

10.5772/20816 ◽  
2011 ◽  
Author(s):  
Yoshiyuki Mizushina ◽  
Masayuki Nishida ◽  
Takeshi Azuma ◽  
Masaru Yoshi
Keyword(s):  
Dna Repair ◽  
Dna Polymerase ◽  
Repair Enzyme ◽  
Curcumin Derivatives ◽  
Dna Polymerase Λ ◽  
Anti Inflammation

scholarly journals Plant DNA polymerase λ, a DNA repair enzyme that functions in plant meristematic and meiotic tissues

2004 ◽  
Vol 271 (13) ◽  
pp. 2799-2807 ◽  
Author(s):  
Yukinobu Uchiyama ◽  
Seisuke Kimura ◽  
Taichi Yamamoto ◽  
Toyotaka Ishibashi ◽  
Kengo Sakaguchi
Keyword(s):  
Dna Repair ◽  
Dna Polymerase ◽  
Repair Enzyme ◽  
Plant Dna ◽  
Dna Polymerase Λ

scholarly journals DNA Polymerase λ, a Novel DNA Repair Enzyme in Human Cells

2002 ◽  
Vol 277 (15) ◽  
pp. 13184-13191 ◽  
Author(s):  
Miguel Garcı́a-Dı́az ◽  
Katarzyna Bebenek ◽  
Rosario Sabariegos ◽  
Orlando Domı́nguez ◽  
Josana Rodrı́guez ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Polymerase ◽  
Human Cells ◽  
Repair Enzyme ◽  
Dna Polymerase Λ

scholarly journals PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Andrew Craxton ◽  
Deeksha Munnur ◽  
Rebekah Jukes-Jones ◽  
George Skalka ◽  
Claudia Langlais ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Polymerase ◽  
Dna Polymerase Λ

Dynamic Characterization of a DNA Repair Enzyme:  NMR Studies of [methyl-13C]Methionine-Labeled DNA Polymerase β

Biochemistry ◽  
2004 ◽  
Vol 43 (28) ◽  
pp. 8911-8922 ◽  
Author(s):  
Bidisha Bose-Basu ◽  
Eugene F. DeRose ◽  
Thomas W. Kirby ◽  
Geoffrey A. Mueller ◽  
William A. Beard ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Polymerase ◽  
Dynamic Characterization ◽  
Dna Polymerase Β ◽  
Nmr Studies ◽  
Repair Enzyme

Comparison of functional properties of mammalian DNA polymerase λ and DNA polymerase β in reactions of DNA synthesis related to DNA repair

2005 ◽  
Vol 1751 (2) ◽  
pp. 150-158 ◽  
Author(s):  
Natalia A. Lebedeva ◽  
Nadejda I. Rechkunova ◽  
Sergey V. Dezhurov ◽  
Svetlana N. Khodyreva ◽  
Alain Favre ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Synthesis ◽  
Dna Polymerase ◽  
Functional Properties ◽  
Dna Polymerase Β ◽  
Dna Polymerase Λ

Long-term efficacy of a new medical device containing Fernblock® and DNA repair enzyme complex in the treatment and prevention of cancerization field in patients with actinic keratosis.

2019 ◽  
Vol 2 (02) ◽  
pp. 80-89
Author(s):  
Blanca De Unamuno Bustos ◽  
Natalia Chaparr´´o Aguilera ◽  
Inmaculada Azorín García ◽  
Anaid Calle Andrino ◽  
Margarita Llavador Ros ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Medical Device ◽  
Actinic Keratosis ◽  
Statistical Significance ◽  
Dna Lesions ◽  
Enzyme Complex ◽  
Repair Enzyme ◽  
P53 Expression ◽  
Cancerization Field

Actinic keratosis (AKs) are part of the cancerization field, a region adjacent to AKs containing subclinical and histologically abnormal epidermal tissue due to Ultraviolet (UV)-induced DNA damage. The photoproducts as consequence of DNA damage induced by UV are mainly cyclobutane pyrimidine dimers (CPDs). Fernblock® demonstrated in previous studies significant reduction of the number of CPDs induced by UV radiation. Photolyases are a specific group of enzymes that remove the major UV-induced DNA lesions by a mechanism called photo-reactivation. A monocentric, prospective, controlled, and double blind interventional study was performed to evaluate the effect of a new medical device (NMD) containing a DNA-repair enzyme complex (photolyases, endonucleases and glycosilases), a combination of UV-filters, and Fernblock® in the treatment of the cancerization field in 30 AK patients after photodynamic therapy. Patients were randomized into two groups: patients receiving a standard sunscreen (SS) andpatients receiving the NMD. Clinical, dermoscopic, reflectance confocal microscopy (RCM) and histological evaluations were performed. An increase of AKs was noted in all groups after three months of PDT without significant differences between them (p=0.476). A significant increase in the number of AKs was observed in SS group after six (p=0.026) and twelve months of PDT (p=0.038); however, this increase did not reach statistical significance in the NMD group. Regarding RCM evaluation, honeycomb pattern assessment after twelve months of PDT showed significant differences in the extension and grade of the atypia in the NMD group compared to SS group (p=0.030 and p=0.026, respectively). Concerning histopathological evaluation, keratinocyte atypia grade improved from baseline to six months after PDT in all the groups, with no statistically significant differences between the groups. Twelve months after PDT, p53 expression was significantly lower in the NMD group compared to SS group (p=0.028). The product was well-tolerated, with no serious adverse events reported. Our results provide evidence of the utility of this NMD in the improvement of the cancerization field and in the prevention of the development of new AKs.  

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