scholarly journals Role of New Appetite Hormones Ghrelin, Orexin-A and Obestatin in the Mechanism of Healing of Chronic Gastric Ulcers

10.5772/19685 ◽  
2011 ◽  
Author(s):  
Thomas Brzozowski ◽  
Aleksandra Szlachcic ◽  
Robert Pajdo ◽  
Zbigniew Sliwowski ◽  
Danuta Drozdowicz ◽  
...  
Keyword(s):  
Gastric Ulcers ◽  
Orexin A

The role of orexin A in pathophysiological mechanisms of sleep disorder in postmenopausal women

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (1) ◽  
pp. 50-54
Author(s):  
Zukhra Kh. Ebzieva ◽  
Svetlana V. Yureneva ◽  
Tatiana Yu. Ivanets
Keyword(s):  
Hormone Therapy ◽  
Sleep Disorder ◽  
Postmenopausal Women ◽  
Menopausal Hormone Therapy ◽  
Reproductive Age ◽  
Vasomotor Symptoms ◽  
Women Of Reproductive Age ◽  
Orexin A ◽  
Group 1

Aim. To conduct a comparative analysis of serum orexin A levels in women of different age periods with and without sleep disorder and vasomotor symptoms. To evaluate the dynamics of orexin A levels under menopausal hormone therapy. Materials and methods. The study included 50 postmenopausal women and 30 women of reproductive age with a regular menstrual cycle. Using block randomization, patients are divided into 3 groups: group 1 (main group), n=25, -STRAW+ 10 (+1b and +1c), patients with sleep disorder and vasomotor symptoms; group 2 (comparison group), n=25, STRAW+ 10 (+1b and +1c), patients with vasomotor symptoms without sleep disorder; group 3 (control group), n=30, STRAW+ 10 (-4), women of reproductive age without sleep disorder. Group 1 patients were given menopausal hormone therapy. A comparative analysis was carried out using the questionnaire for assessing menopausal symptoms severity by the Greene Scale (the Greene Climacteric Scale) and Rating Scale for subjective sleep characteristics. After 12 weeks of treatment, a control examination was performed. Results. In group 1 women, the serum orexin A levels were significantly higher compared to the women without the symptoms. The link between the orexin A levels and menopause syndrome severity was established. A significant decrease in the menopausal symptoms severity after 12 weeks of menopausal hormone therapy was shown. It was accompanied by a 1,3-fold decrease in orexin A levels. Conclusions. The obtained data indicate the possible role of orexin A and the orexin neuropeptide system in the pathogenesis of sleep disorder and vasomotor symptoms in postmenopausal women.

scholarly journals Management of Giant Gastric Ulcer Perforation: Report of a Case and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Nitin Vashistha ◽  
Dinesh Singhal ◽  
Gurpreet Makkar ◽  
Suneel Chakravarty ◽  
Vivek Raj
Keyword(s):  
Gastric Ulcer ◽  
Multidetector Ct ◽  
Symptom Relief ◽  
Gastric Ulcers ◽  
Review Of The Literature ◽  
H2 Receptor Antagonist ◽  
Factors Affecting ◽  
High Incidence ◽  
Surgical Options

Giant gastric ulcer (GGU) is defined as an ulcer more than 3 cm in diameter. Now infrequent in clinical practice, in the pre-H2 receptor antagonist (H2RA) era, the incidence of GGU varied between 12 and 24% of all gastric ulcers. Proton pump inhibitors reportedly achieve better healing rates and symptom relief in comparison to H2RA. The GGU is associated with high incidence of serious complications such as hemorrhage. A perforated GGU though rare (<2%) offers serious challenges in management. We report one such case wherein the role of multidetector CT scan (MDCT) for diagnosis and treatment planning, surgical options for GGU perforations, and factors affecting outcome are discussed.

Role of pancreatic secretory trypsin inhibitor (PSTI) in healing of chronic gastric ulcers in rats

1998 ◽  
Vol 114 ◽  
pp. A889
Author(s):  
PC. Konturek ◽  
T. Brzozowski ◽  
SJ. Konturek ◽  
S. Yagi ◽  
G. Elia ◽  
...  
Keyword(s):  
Trypsin Inhibitor ◽  
Gastric Ulcers ◽  
Pancreatic Secretory Trypsin Inhibitor

scholarly journals In vivo evidence for the role of RegI in gastric regeneration: transgenic overexpression of RegI accelerates the healing of experimental gastric ulcers

2010 ◽  
Vol 90 (4) ◽  
pp. 556-565 ◽  
Author(s):  
Hiroyuki Fukuhara ◽  
Yasunori Kadowaki ◽  
Takayuki Ose ◽  
Aziz Monowar ◽  
Hiroshi Imaoka ◽  
...  
Keyword(s):  
Gastric Ulcers

scholarly journals Role of Cyclooxygenase (COX)-2 in Healing of Gastric Ulcers in Rats

1998 ◽  
Vol 76 ◽  
pp. 121
Author(s):  
Jun-ichi Shigeta ◽  
Satoru Takahashi ◽  
Susumu Okabe
Keyword(s):  
Gastric Ulcers ◽  
Cox 2

Role of prostaglandins in the formation of aspirin-induced gastric ulcers

1981 ◽  
Vol 80 (1) ◽  
pp. 4-9 ◽  
Author(s):  
Stanisław J. Konturek ◽  
Ireneusz Piastucki ◽  
Tomasz Brzozowski ◽  
Tadeusz Radecki ◽  
Aldona Dembińska-Kieć ◽  
...  
Keyword(s):  
Gastric Ulcers

Role of gastric acid secretion in progression of acute gastric erosions induced by ischemia–reperfusion into gastric ulcers

2000 ◽  
Vol 398 (1) ◽  
pp. 147-158 ◽  
Author(s):  
Tomasz Brzozowski ◽  
Peter Ch Konturek ◽  
Stanislaw J Konturek ◽  
Danuta Drozdowicz ◽  
Slawomir Kwiecieñ ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Ischemia Reperfusion ◽  
Gastric Ulcers ◽  
Gastric Erosions
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