scholarly journals Biomimetic Modifications of Calcium Orthophosphates

10.5772/19054 ◽  
2011 ◽  
Author(s):  
Diana Rabadjieva ◽  
Stefka Tepavitcharova ◽  
Kostadinka Sezanova ◽  
Rumyana Gergulova ◽  
Rositsa Titorenkova ◽  
...  
Keyword(s):  
Calcium Orthophosphates

scholarly journals Microwave-Assisted Fabrication of Mesoporous Silica-Calcium Phosphate Composites for Dental Application

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 53
Author(s):  
Adrian Szewczyk ◽  
Adrianna Skwira ◽  
Marta Ginter ◽  
Donata Tajer ◽  
Magdalena Prokopowicz
Keyword(s):  
Calcium Phosphate ◽  
Mesoporous Silica ◽  
Octacalcium Phosphate ◽  
Precipitation Method ◽  
X Ray Diffraction ◽  
Coating Solution ◽  
X Ray ◽  
Microwave Assisted ◽  
Calcium Orthophosphates ◽  
Different Types

Herein, the microwave-assisted wet precipitation method was used to obtain materials consisting of mesoporous silica (SBA-15) and calcium orthophosphates (CaP). Composites were prepared through immersion of mesoporous silica in different calcification coating solutions and then exposed to microwave radiation. The composites were characterized in terms of molecular structure, crystallinity, morphology, chemical composition, and mineralization potential by Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (XRD), and scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM-EDX). The application of microwave irradiation resulted in the formation of different types of calcium orthophosphates such as calcium deficient hydroxyapatite (CDHA), octacalcium phosphate (OCP), and amorphous calcium phosphate (ACP) on the SBA-15 surface, depending on the type of coating solution. The composites for which the progressive formation of hydroxyapatite during incubation in simulated body fluid was observed were further used in the production of final pharmaceutical forms: membranes, granules, and pellets. All of the obtained pharmaceutical forms preserved mineralization properties.

Synthetic amorphous calcium phosphates (ACPs):preparation, structure, properties and biomedical applications

2021 ◽  
Author(s):  
Sergey V Dorozhkin
Keyword(s):  
Physical Properties ◽  
Biomedical Applications ◽  
Calcium Phosphates ◽  
Amorphous State ◽  
Calcium Orthophosphates ◽  
Structure Properties

Amorphous calcium phosphates (ACPs) represent a metastable amorphous state of other calcium orthophosphates (abbreviated as CaPO4) possessing variable compositional but rather identical glass-like physical properties, in which there are neither...

Studies on the Availability of Calcium Orthophosphates to Chickens and Turkeys

1962 ◽  
Vol 78 (2) ◽  
pp. 155-161 ◽  
Author(s):  
M. B. Gillis ◽  
H. M. Edwards ◽  
R. J. Young
Keyword(s):  
Calcium Orthophosphates

Calcium orthophosphates

2007 ◽  
Vol 42 (4) ◽  
pp. 1061-1095 ◽  
Author(s):  
Sergey V. Dorozhkin
Keyword(s):  
Calcium Orthophosphates

Nano-Sized and Nanocrystalline Calcium Orhophosphates in Biomedical Engineering

2009 ◽  
Vol 3 ◽  
pp. 59-92 ◽  
Author(s):  
Sergey V. Dorozhkin
Keyword(s):  
Bone Repair ◽  
Dental Enamel ◽  
Building Blocks ◽  
Research Area ◽  
Future Research ◽  
Biological Origin ◽  
Current State ◽  
Calcium Orthophosphates ◽  
Recent Developments ◽  
Hard Tissue Engineering

There has been much recent activity in the research area of nanoparticles and nanocrystalline materials, in many fields of science and technology. This is due to their outstanding and unique physical, mechanical, chemical and biological characteristics. Recent developments in biomineralization have demonstrated that nano-sized particles play an important role in the formation of the hard tissues of animals. It is well established that the basic inorganic building blocks of bones and teeth of mammals are nano-sized and nanocrystalline calcium orthophosphates (in the form of apatites) of a biological origin. In mammals, tens to hundreds of nanocrystals of biological apatite are found to combine into self-assembled structures under the control of bio-organic matrixes. It was also confirmed experimentally that the structure of both dental enamel and bones could be mimicked by an oriented aggregation of nano-sized calcium orthophosphates, determined by the biomolecules. The application and prospective use of nano-sized and nanocrystalline calcium orthophosphates for clinical repair of damaged bones and teeth are also known. For example, a greater viability and a better proliferation of various cells were detected on smaller crystals of calcium orthophosphates. Furthermore, studies revealed that the differentiation of various cells was promoted by nano-sized calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have the potential to revolutionize the field of hard tissue engineering, in areas ranging from bone repair and augmentation to controlled drug delivery devices. This paper reviews the current state of knowledge and recent developments of various nano-sized and nanocrystalline calcium orthophosphates, covering topics from the synthesis and characterization to biomedical and clinical applications. This review also provides possible directions of future research and development.

scholarly journals Synthesis of Calcium Orthophosphates by Chemical Precipitation in Aqueous Solutions: The Effect of the Acidity, Ca/P Molar Ratio, and Temperature on the Phase Composition and Solubility of Precipitates

Processes ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 1009
Author(s):  
Mykola V. Nikolenko ◽  
Kateryna V. Vasylenko ◽  
Victoria D. Myrhorodska ◽  
Andrii Kostyniuk ◽  
Blaž Likozar
Keyword(s):  
Solid Phase ◽  
Chemical Precipitation ◽  
Molar Ratio ◽  
Key Factors ◽  
Correlation Dependence ◽  
Molar Ratios ◽  
Calcium Orthophosphates ◽  
Calcium Cations ◽  
Solubility Isotherms ◽  
Solubility Products

Studies on chemical precipitation of the calcium orthophosphates have shown that their phase compositions do not vary depending on molar ratio Ca/P but are sensitive to solutions acidity and temperature. These are two key factors that determine the phase transformation progress of metastable phases into less soluble precipitates of the phosphates. It was proposed to compare calcium orthophosphates solubility products with calcium cations quantities in their formulas. It was found that there was a linear correlation between calcium orthophosphates specific solubility products and their molar ratios Ca/P if hydroxyapatite and its Ca-deficient forms were excluded from consideration. It was concluded that the relatively large deviations of their solubility products from the found correlation should be thought of as erroneous data. That is why solubility products were changed in accordance with correlation dependence: pKS for hydroxyapatite was 155, pKS for Ca-deficient hydroxyapatites was 114–155. The solubility isotherms, which were calculated on the basis of the corrected pKS values, coincided with the experimental data on solid-phase titration by Pan and Darvell.

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