Down Syndrome and Periodontal Disease

10.5772/17371 ◽  
2011 ◽  
Author(s):  
Ahmed Khocht
Keyword(s):  
Down Syndrome ◽  
Periodontal Disease

scholarly journals Differential Expression of Inflammation-Related Genes in Down Syndrome Patients with or without Periodontal Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
M. Baus-Domínguez ◽  
R. Gómez-Díaz ◽  
D. Torres-Lagares ◽  
J. R. Corcuera-Flores ◽  
J. C. Ruiz-Villandiego ◽  
...  
Keyword(s):  
Gene Expression ◽  
Down Syndrome ◽  
Periodontal Disease ◽  
Differential Expression ◽  
Clinical Feature ◽  
Related Gene ◽  
Thermo Fisher Scientific ◽  
Oral Inflammation ◽  
Fisher Scientific

Aim. Aware that Down Syndrome patients present among their clinical characteristics impaired immunity, the aim of this study is to identify the statistically significant differences in inflammation-related gene expression by comparing Down Syndrome patients with Periodontal Disease (DS+PD+) with Down Syndrome patients without Periodontal Disease (DS+PD-), and their relationship with periodontitis as a chronic oral inflammatory clinical feature. Materials and Methods. Case study and controls on eleven Down Syndrome patients (DS+PD+ vs. DS+PD-). RNA was extracted from peripheral blood using a Qiagen PAXgene Blood miRNA Kit when performing an oral examination. A search for candidate genes (92 selected) was undertaken on the total genes obtained using a Scientific GeneChip® Scanner 3000 (Thermo Fisher Scientific) and Clariom S solutions for human, mouse, and rat chips, with more than 20,000 genes annotated for measuring expression levels. Results. Of the 92 inflammation-related genes taken initially, four genes showed a differential expression across both groups with a p value of <0.05 from the data obtained using RNA processing of the patient sample. Said genes were TNFSF13B (p=0.0448), ITGB2 (p=0.0033), ANXA3 (p=0.0479), and ANXA5 (p=0.016). Conclusions. There are differences in inflammation-related gene expression in Down Syndrome patients when comparing patients who present a state of chronic oral inflammation with patients with negative rates of periodontal disease.

Periodontal disease in patients with Down syndrome

2018 ◽  
Vol 149 (7) ◽  
pp. 628-639.e11 ◽  
Author(s):  
Flávia Almeida Ribeiro Scalioni ◽  
Camila Faria Carrada ◽  
Carolina Castro Martins ◽  
Rosangela Almeida Ribeiro ◽  
Saul Martins Paiva
Keyword(s):  
Down Syndrome ◽  
Periodontal Disease

scholarly journals Etiologic factors of early-onset periodontal disease in Down syndrome

2008 ◽  
Vol 44 (2) ◽  
pp. 118-127 ◽  
Author(s):  
Atsuo Amano ◽  
Jumpei Murakami ◽  
Shigehisa Akiyama ◽  
Ichijiro Morisaki
Keyword(s):  
Down Syndrome ◽  
Periodontal Disease ◽  
Early Onset

Oral infection, periodontal disease and cytokine production in adults with Down syndrome

2017 ◽  
Vol 5 (3) ◽  
Author(s):  
Miki Kosaka ◽  
Hidenobu Senpuku ◽  
Asami Hagiwara ◽  
Yoshiaki Nomura ◽  
Nobuhiro Hanada
Keyword(s):  
Down Syndrome ◽  
Periodontal Disease ◽  
Cytokine Production ◽  
Oral Infection

scholarly journals ORAL HYGIENE OF DOWN SYNDROME CHILDREN BORN TO ELDERLY PRIMIGRAVIDA

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Asha Nara ◽  
Imit Pal Saluja ◽  
Sabitha Ramisetty ◽  
Abhishek Sinha ◽  
Rajsekhar. B
Keyword(s):  
Down Syndrome ◽  
Dental Caries ◽  
Periodontal Disease ◽  
Oral Hygiene ◽  
Heart Diseases ◽  
Past History ◽  
The Elderly ◽  
Reproductive Age ◽  
Obstetric History ◽  
Clinical Presentations

Materials and methods: Prospective study of reproductive age group of female patients in the range of 30-39 years were included in the study who had conceived for the first time -elderly primigravida were obtained from Navodaya hospitals during the period of 2017 to 2019 in Karnataka who had bad obstetric history with high risk of complications of hypertension, fibroids, malpresentation, malposition, prolonged labour, premature labour and perinatal mortality. Few of the elderly primigravida had past history of anaemia, diabetes and heart diseases. Children born to them who were suspected to be suffering from Down syndrome were evaluated genetically. Children suffering from Down syndrome who had bad oral hygiene comprising periodontal disease, dental caries, facial and dental anomalies and other clinical presentations like compromised immune system, hypotonia, seizures were included in the study of age ranging from 01-10 years. Total data obtained for a period of 3years were 108 children of which 62 were boys and remaining girls 46. Periodontal disease was the most common oral health problem in children with Down syndrome born to elderly primigravida with bad obstetric history followed by dental caries. Results: In the genetic evaluation the children who were suffering from Down syndrome found out to be was standard trisomy (83.6%), comparing to translocation1 and mosaicism. Majority of the children presented with periodontal disease were 33 (30.6%), of which 23 boys and remaining girls. Dental caries17 (15.7%), boys presented were 10 and the remaining cases were girls (07). Conclusion: Majority of the Down syndrome children presented with periodontal disease and caries teeth apart from other clinical presentations. Keywords: Elderly primigravida, Down syndrome, bad oral hygiene.

scholarly journals Using Genetics in Periodontal Disease to Justify Implant Failure in Down Syndrome Patients

2020 ◽  
Vol 9 (8) ◽  
pp. 2525
Author(s):  
Maria Baus-Domínguez ◽  
Raquel Gómez-Díaz ◽  
Jose-Ramón Corcuera-Flores ◽  
Daniel Torres-Lagares ◽  
José-Cruz Ruiz-Villandiego ◽  
...  
Keyword(s):  
Gene Expression ◽  
Down Syndrome ◽  
Periodontal Disease ◽  
Case Control Study ◽  
Case Control ◽  
Implant Failure ◽  
Retrospective Case ◽  
Thermo Fisher Scientific ◽  
Control Study ◽  
Fisher Scientific

Peri-implant bone loss leading to dental implant failure does not develop in the same way across subjects who apparently present the same condition—specifically, in the case of Down syndrome patients with the same genetic disorder—given that they do not necessarily develop immune–inflammatory disorders to the same extent. Methods: This retrospective case-control study was aimed at identifying the possible genes involved in implant failure in Down syndrome patients by matching the periodontal disease variable by means of a retrospective case-control study. This process involved using the functional analysis of gene expression software Transcriptome Analysis Console (TAC, Affymetrix, Thermo Fisher Scientific, Waltham, MA, USA) and a search for the possible candidate genes involved. Focus was placed on the 92 genes related to the inflammation identified from the TaqMan™ Array Plate Human Inflammation Kit (Thermo Fisher Scientific, Waltham, MA, USA). Results: Six genes showed statistically significant results (p < 0.05) in our comparison. Three of them—PLCG2 (p = 0.0333), ALOX5 (p = 0.03) and LTAH4 (p = 0.0081)—were overexpressed in the implant reject group, and the following three were down-regulated: VCAM1 (p = 0.0182), PLA2G2A (p = 0.0034) and PLA2G10 (p = 0.047). Conclusion: Statistically significant differences exist in the gene expression involved in osteoclastogenesis, inflammatory response and host defensive response.

Sign in / Sign up

Export Citation Format

Share Document