scholarly journals Using Genetics in Periodontal Disease to Justify Implant Failure in Down Syndrome Patients

2020 ◽  
Vol 9 (8) ◽  
pp. 2525
Author(s):  
Maria Baus-Domínguez ◽  
Raquel Gómez-Díaz ◽  
Jose-Ramón Corcuera-Flores ◽  
Daniel Torres-Lagares ◽  
José-Cruz Ruiz-Villandiego ◽  
...  
Keyword(s):  
Gene Expression ◽  
Down Syndrome ◽  
Periodontal Disease ◽  
Case Control Study ◽  
Case Control ◽  
Implant Failure ◽  
Retrospective Case ◽  
Thermo Fisher Scientific ◽  
Control Study ◽  
Fisher Scientific

Peri-implant bone loss leading to dental implant failure does not develop in the same way across subjects who apparently present the same condition—specifically, in the case of Down syndrome patients with the same genetic disorder—given that they do not necessarily develop immune–inflammatory disorders to the same extent. Methods: This retrospective case-control study was aimed at identifying the possible genes involved in implant failure in Down syndrome patients by matching the periodontal disease variable by means of a retrospective case-control study. This process involved using the functional analysis of gene expression software Transcriptome Analysis Console (TAC, Affymetrix, Thermo Fisher Scientific, Waltham, MA, USA) and a search for the possible candidate genes involved. Focus was placed on the 92 genes related to the inflammation identified from the TaqMan™ Array Plate Human Inflammation Kit (Thermo Fisher Scientific, Waltham, MA, USA). Results: Six genes showed statistically significant results (p < 0.05) in our comparison. Three of them—PLCG2 (p = 0.0333), ALOX5 (p = 0.03) and LTAH4 (p = 0.0081)—were overexpressed in the implant reject group, and the following three were down-regulated: VCAM1 (p = 0.0182), PLA2G2A (p = 0.0034) and PLA2G10 (p = 0.047). Conclusion: Statistically significant differences exist in the gene expression involved in osteoclastogenesis, inflammatory response and host defensive response.

scholarly journals Correction: Growth of the hard palate in infants with Down syndrome compared with healthy infants—A retrospective case control study

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0203899
Author(s):  
Daniel Klingel ◽  
Ariane Hohoff ◽  
Robert Kwiecien ◽  
Dirk Wiechmann ◽  
Thomas Stamm
Keyword(s):  
Down Syndrome ◽  
Hard Palate ◽  
Case Control Study ◽  
Case Control ◽  
Retrospective Case ◽  
Healthy Infants ◽  
Control Study

scholarly journals Differential Expression of Inflammation-Related Genes in Down Syndrome Patients with or without Periodontal Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
M. Baus-Domínguez ◽  
R. Gómez-Díaz ◽  
D. Torres-Lagares ◽  
J. R. Corcuera-Flores ◽  
J. C. Ruiz-Villandiego ◽  
...  
Keyword(s):  
Gene Expression ◽  
Down Syndrome ◽  
Periodontal Disease ◽  
Differential Expression ◽  
Clinical Feature ◽  
Related Gene ◽  
Thermo Fisher Scientific ◽  
Oral Inflammation ◽  
Fisher Scientific

Aim. Aware that Down Syndrome patients present among their clinical characteristics impaired immunity, the aim of this study is to identify the statistically significant differences in inflammation-related gene expression by comparing Down Syndrome patients with Periodontal Disease (DS+PD+) with Down Syndrome patients without Periodontal Disease (DS+PD-), and their relationship with periodontitis as a chronic oral inflammatory clinical feature. Materials and Methods. Case study and controls on eleven Down Syndrome patients (DS+PD+ vs. DS+PD-). RNA was extracted from peripheral blood using a Qiagen PAXgene Blood miRNA Kit when performing an oral examination. A search for candidate genes (92 selected) was undertaken on the total genes obtained using a Scientific GeneChip® Scanner 3000 (Thermo Fisher Scientific) and Clariom S solutions for human, mouse, and rat chips, with more than 20,000 genes annotated for measuring expression levels. Results. Of the 92 inflammation-related genes taken initially, four genes showed a differential expression across both groups with a p value of <0.05 from the data obtained using RNA processing of the patient sample. Said genes were TNFSF13B (p=0.0448), ITGB2 (p=0.0033), ANXA3 (p=0.0479), and ANXA5 (p=0.016). Conclusions. There are differences in inflammation-related gene expression in Down Syndrome patients when comparing patients who present a state of chronic oral inflammation with patients with negative rates of periodontal disease.

scholarly journals Growth of the hard palate in infants with Down syndrome compared with healthy infants—A retrospective case control study

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0182728 ◽  
Author(s):  
Daniel Klingel ◽  
Ariane Hohoff ◽  
Robert Kwiecien ◽  
Dirk Wiechmann ◽  
Thomas Stamm
Keyword(s):  
Down Syndrome ◽  
Hard Palate ◽  
Case Control Study ◽  
Case Control ◽  
Retrospective Case ◽  
Healthy Infants ◽  
Control Study

Assessment of Craniofacial Morphology in Mouth Breathing Children. A retrospective case-control study

2019 ◽  
Vol 70 (10) ◽  
pp. 3649-3653
Author(s):  
David Angelescu ◽  
Teodora Angelescu ◽  
Meda Romana Simu ◽  
Alexandrina Muntean ◽  
Anca Stefania Mesaros ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Craniofacial Morphology ◽  
Respiratory Pattern ◽  
Control Group ◽  
Upper Lip ◽  
Retrospective Case ◽  
Oral Breathing ◽  
Facial Height ◽  
Control Study

The aim of this retrospective case-control study is to determine a possible correlation between breathing mode and craniofacial morphology. The study was carried out in the Department of Pedodontics,Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. The sample comprised 80 patients, age between 6 and 13 years, which were divided in two groups based on respiratory pattern: control group composed of 38 nasal breathing children and case group composed of 42 oral breathing children. Three quantitative craniofacial parameters were measured from the frontal and lateral photos: facial index, lower facial height ratio and upper lip ratio. The statistical analysis showed a significant higher facial index (p=0.006*) and an increase lower facial height (p=0.033*) for the oral breathers group. No differences in facial morphology were found between genders and age groups, when comparing the data between the same type of respiratory pattern children. Spearman�s rho Correlation show a significant positive correlation (p=0.002*) between facial index and lower facial height and a significant negative correlation between facial index and upper lip (p=0,005*). Long faces children are more likely to develop oral breathing in certain conditions, which subsequently have a negative effect on increasing the lower facial height by altering the postural behavior of mandible and tongue.

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