scholarly journals ESC Cardiac Differentiation and Applications

10.5772/14586 ◽  
2011 ◽  
Author(s):  
Nasser Aghami ◽  
Hananeh Fonoudi
Keyword(s):  
Cardiac Differentiation

scholarly journals Cues from human atrial extracellular matrix enrich the atrial differentiation of human induced pluripotent stem cell-derived cardiomyocytes

2021 ◽  
Author(s):  
Fernanda C. P. Mesquita ◽  
Jacquelynn Morrissey ◽  
Po-Feng Lee ◽  
Gustavo Monnerat ◽  
Yutao Xi ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Cardiac Differentiation ◽  
Twofold Increase ◽  
Decellularized Extracellular Matrix ◽  
Induced Pluripotent

Decellularized extracellular matrix (dECM) from human atria preserves key native components that directed the cardiac differentiation of hiPSCs to an atrial-like phenotype, yielding a twofold increase of functional atrial-like cells.

scholarly journals Role of Cavβ subunits in cardiac differentiation

2018 ◽  
Vol 10 (2) ◽  
pp. 211
Author(s):  
S. De Waard ◽  
V. Forest ◽  
N. Gaborit ◽  
M. Ronjat ◽  
M. De Waard ◽  
...  
Keyword(s):  
Cardiac Differentiation

scholarly journals 5-azacytidine induces cardiac differentiation of P19 embryonic stem cells

2004 ◽  
Vol 36 (6) ◽  
pp. 515-523 ◽  
Author(s):  
Seung-Cheol Choi ◽  
Jihyun Yoon ◽  
Wan-Joo Shim ◽  
Young-Moo Ro ◽  
Do-Sun Lim
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cardiac Differentiation

Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia

Development ◽  
1996 ◽  
Vol 122 (11) ◽  
pp. 3549-3556 ◽  
Author(s):  
O.B. Cleaver ◽  
K.D. Patterson ◽  
P.A. Krieg
Keyword(s):  
Heart Development ◽  
Homeobox Gene ◽  
Cardiac Differentiation ◽  
Myocardial Cells ◽  
Differentiation Markers ◽  
Heart Field ◽  
Cardiac Mesoderm ◽  
Xenopus Laevis Embryos ◽  
Functional Homologues

Drosophila tinman is an NK-class homeobox gene required for formation of the dorsal vessel, the insect equivalent of the vertebrate heart. Vertebrate sequences related to tinman, such as mouse Nkx-2.5, chicken cNkx-2.5, Xenopus XNkx-2.5 and XNkx-2.3 are expressed in cardiac precursors and in tissues involved in induction of cardiac mesoderm. Mice which lack a functional Nkx-2.5 gene die due to cardiac defects. To determine the role of tinman-related sequences in heart development, we have overexpressed both XNkx-2.3 and XNkx-2.5 in Xenopus laevis embryos. The resulting embryos are morphologically normal except that they have enlarged hearts. The enlarged heart phenotype is due to a thickening of the myocardium caused by an increase in the overall number of myocardial cells (hyperplasia). Neither ectopic nor precocious expression of cardiac differentiation markers is detectable in overexpressing embryos. These results suggest that both XNkx-2.3 and XNkx-2.5 are functional homologues of tinman, responsible for maintenance of the heart field.

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