Recent Advances in Robust Control - Novel Approaches and Design Methods

10.5772/1023 ◽  
2011 ◽  
2021 ◽  
Author(s):  
Michael Browning ◽  
Quentin JM Huys

Anhedonia—a common feature of depression—encompasses a reduction in the subjective experience and anticipation of rewarding events, and a reduction in the motivation to seek out such events. The presence of anhedonia often predicts or accompanies treatment resistance, and as such better interventions and treatments are important. Yet the mechanisms giving rise to anhedonia are not well-understood. In this chapter, we briefly review existing computational conceptualisations of anhedonia. We argue that they are mostly descriptive and fail to provide anexplanatory account of why anhedonia may occur. Working within the framework of reinforcement learning, we examine two potential computational mechanisms that could give rise to anhedonic phenomena. First, we show how anhedonia can arise in multidimensional drive reduction settings through a trade-off between different rewards or needs. We then generalize this in terms of model-based value inference and identify a key role for associational belief structure. We close with a brief discussion of treatment implications of both of these conceptualisations. Insummary, computational accounts of anhedonia have provided a useful descriptive framework. Recent advances in reinforcement learning suggest promising avenues by which the mechanisms underlying anhedonia may be teased apart, potentially motivating novel approaches to treatment.


BioEssays ◽  
1994 ◽  
Vol 16 (9) ◽  
pp. 683-687 ◽  
Author(s):  
Philip M. Dean

Author(s):  
Nagini Devarakonda ◽  
Rama K. Yedavalli

In this paper, a new methodology for robust control design of linear systems with time varying real parameter uncertainty is presented. The distinctive feature of this method is that it specifically offers robustness guarantees to real parameter uncertainty thereby providing a much needed alternative design method compared to existing design methods such as H∞ and μ-synthesis methods which tend to be conservative when specialized to real parameter uncertainty. The proposed robust control design method is inspired by sign (qualitative) stability idea from ecology, leading to a specific structure in the desired closed loop system matrix involving pseudosymmetry. The design procedure is simple and straightforward without requiring intensive computation. The proposed design algorithm is illustrated with aerospace applications. This algorithm is quite promising with considerable scope for extensions and improvements, finally adding to the bank of available control design methods for linear state space systems.


Materials ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4290
Author(s):  
Melitini Koutsoviti ◽  
Angeliki Siamidi ◽  
Panagoula Pavlou ◽  
Marilena Vlachou

In ocular drug delivery, maintaining an efficient concentration of the drug in the target area for a sufficient period of time is a challenging task. There is a pressing need for the development of effective strategies for drug delivery to the eye using recent advances in material sciences and novel approaches to drug delivery. This review summarizes the important aspects of ocular drug delivery and the factors affecting drug absorption in the eye including encapsulating excipients (chitosan, hyaluronic acid, poloxamer, PLGA, PVCL-PVA-PEG, cetalkonium chloride, and gelatin) for modified drug delivery.


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