scholarly journals Recent Advances in the Excipients Used for Modified Ocular Drug Delivery

Materials ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4290
Author(s):  
Melitini Koutsoviti ◽  
Angeliki Siamidi ◽  
Panagoula Pavlou ◽  
Marilena Vlachou

In ocular drug delivery, maintaining an efficient concentration of the drug in the target area for a sufficient period of time is a challenging task. There is a pressing need for the development of effective strategies for drug delivery to the eye using recent advances in material sciences and novel approaches to drug delivery. This review summarizes the important aspects of ocular drug delivery and the factors affecting drug absorption in the eye including encapsulating excipients (chitosan, hyaluronic acid, poloxamer, PLGA, PVCL-PVA-PEG, cetalkonium chloride, and gelatin) for modified drug delivery.

Author(s):  
Gyan Mishra ◽  
Ripal Gaudana ◽  
Viral Tamboli ◽  
Ashim Mitra

2012 ◽  
Vol 39 (11) ◽  
pp. 1599-1617 ◽  
Author(s):  
Djamila Achouri ◽  
Kamel Alhanout ◽  
Philippe Piccerelle ◽  
Véronique Andrieu

Polymers ◽  
2011 ◽  
Vol 3 (1) ◽  
pp. 193-221 ◽  
Author(s):  
Noriyuki Kuno ◽  
Shinobu Fujii

2016 ◽  
Vol 32 (2) ◽  
pp. 67-82 ◽  
Author(s):  
Venkata Kashyap Yellepeddi ◽  
Srinath Palakurthi

2015 ◽  
Vol 97 ◽  
pp. 400-416 ◽  
Author(s):  
Giuseppe Tripodo ◽  
Adriana Trapani ◽  
Maria Luisa Torre ◽  
Gaetano Giammona ◽  
Giuseppe Trapani ◽  
...  

Pharmaceutics ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 22 ◽  
Author(s):  
Natallia Dubashynskaya ◽  
Daria Poshina ◽  
Sergei Raik ◽  
Arto Urtti ◽  
Yury A. Skorik

Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies. The properties of polysaccharides can be extensively modified to optimize ocular drug formulations and to obtain biocompatible and biodegradable drugs with improved bioavailability and tailored pharmacological effects. This review discusses the available polysaccharide choices for overcoming the difficulties associated with ocular drug delivery, and it explores the reasons for the dependence between the physicochemical properties of polysaccharide-based drug carriers and their efficiency in different formulations and applications. Polysaccharides will continue to be of great interest to researchers endeavoring to develop ophthalmic drugs with improved effectiveness and safety.


Sign in / Sign up

Export Citation Format

Share Document