Multi-Center Study Regarding the Risk Factors for Bleeding in Gastrointestinal Stromal Tumor

2012 ◽  
Author(s):  
Kyung Sik Park ◽  
Kyu Chan Huh ◽  
Ilseon Hwang ◽  
Jung Hyeok Kwon ◽  
Joong Goo Kwon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Multi Center Study ◽  
Center Study

Clinical, Pathological and Surgical Characteristics of Duodenal Gastrointestinal Stromal Tumor and Their Influence on Survival: A Multi-Center Study

2012 ◽  
Vol 19 (11) ◽  
pp. 3361-3367 ◽  
Author(s):  
C. Colombo ◽  
U. Ronellenfitsch ◽  
Z. Yuxin ◽  
P. Rutkowski ◽  
R. Miceli ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Multi Center Study ◽  
Center Study

scholarly journals Epidemiological and Clinical Risk Factors Related to Severe COVID-19 in Iran: A multi-center study

2020 ◽  
Author(s):  
Seyed Mohammad Hashemi-Shahri ◽  
Seyed Mohammad Nasiraldin Tabatabaei ◽  
Alireza Ansari-moghaddam ◽  
Mahdi Mohammadi ◽  
Hassan Okati-Aliabad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Substance Abuse ◽  
Disease Severity ◽  
Underlying Disease ◽  
Severe Condition ◽  
Factors Affecting ◽  
Logistic Regression Models ◽  
Factors Associated ◽  
Multi Center Study ◽  
Center Study

Abstract Background Iran was one of the first countries to be affected by COVID-19. Identifying factors associated with severity of COVID-19 is effective in disease management. This study investigated the epidemiological and clinical features and factors associated with severity of COVID-19 in one of the less privileged areas in Iran.Methods In a multi-center study, all patients admitted to hospitals of Zahedan University of Medical Sciences located in southeastern Iran were investigated from February 29 to April 31, 2020. Demographic, epidemiological and clinical data of patients were extracted from medical records. To explore the risk factors associated with severity of COVID-19, bivariate and multivariate logistic regression models were used.Results Among the 413 patients, 55.5% were male and 145 (35.10%) were in a severe condition at admission time. Multivariate analysis showed that the adjusted odds of the disease severity increased in patients with older age (OR 3.51; 95% CI, 2.28-5.40), substance abuse (OR 2.22; 95% CI, 2.05-5.78) and at least one underlying disease (OR 3.45; 95% CI, 1.01-1.32).Conclusions COVID-19 was more severe in older patients, patients with a history of substance abuse, and patients with at least one underlying disease. Understanding the factors affecting the disease severity can help for clinical management of COVID-19, especially in less privileged areas where fewer resources are available.

THE EXPRESS OF SOME MARKERS, RISK STRATIFICATION AND THE RELATION WITH THE OTHER RISK FACTORS IN GIST

2016 ◽  
pp. 109-115
Author(s):  
Van Mao Nguyen ◽  
Xuan Tien Tran
Keyword(s):  
Risk Factors ◽  
Risk Stratification ◽  
Gastrointestinal Stromal Tumor ◽  
Cross Sectional Study ◽  
Stromal Tumor ◽  
Surgical Pathology ◽  
Risk Level ◽  
Mesenchymal Tumors ◽  
Cross Sectional ◽  
Choice Of Treatment

Background: Gastrointestinal Stromal Tumor (GIST) is the most frequent one among the digestive mesenchymal tumors. GIST usually locates under the mucosa of the stomach, esophagus, small intestine, colorectal intestine and evenly sometimes at the mesentery, omentum. Microscopically, GIST appeares as various features. In order to determine the origin of the tumor cell, surgical pathology especially the immunohistochemistry play a key role for the best choice of treatment with the targeted therapy. Objectives: - To study some of the common characteristics of the surgical pathology and immunohistochemistry of GIST. – To apply the GIST Risk Stratification of AFIP 2006 and determine the relation with some of the traditional risk factors. Materials and Method: cross-sectional study of 39 patients diagnosed with GIST at Hue Central Hospital from 6/2011 to 7/2015. Results: the average age 55.87±11.91, the most frequent age 41-60 in both men and women. The tumor size >2-5cm was the most rate 64.1%, GIST mostly located at the stomach, accounting for 48.7%. The spindle cell GISTs were the highest type 87.2%. Immunohistochemistry shown that the positive of CD117, Vimentine, CD34 were 100%, 94.7% and 61.5% respectively. All GISTs were negative for Desmine. The high risk GISTs were the most frequent accounting for 46.2%, following the moderate ones 28.2%, then the low 20.5%, the very low only 5.1%. This study also shown that, there were the relation between the tumor risk level with the tumor necrosis and the mucosa invasion. Conclusion: The application of the Immunohistochemistry with the marker CD117 and the GIST Risk Stratification need carry out for the digestive mesenchymal tumors to choose the best treatment for the patients. Key words: gastrointestinal stromal tumor (GIST), mesenchymal tumor, histopathology, immunohistochemistry

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