THE EXPRESS OF SOME MARKERS, RISK STRATIFICATION AND THE RELATION WITH THE OTHER RISK FACTORS IN GIST

2016 ◽  
pp. 109-115
Author(s):  
Van Mao Nguyen ◽  
Xuan Tien Tran
Keyword(s):  
Risk Factors ◽  
Risk Stratification ◽  
Gastrointestinal Stromal Tumor ◽  
Cross Sectional Study ◽  
Stromal Tumor ◽  
Surgical Pathology ◽  
Risk Level ◽  
Mesenchymal Tumors ◽  
Cross Sectional ◽  
Choice Of Treatment

Background: Gastrointestinal Stromal Tumor (GIST) is the most frequent one among the digestive mesenchymal tumors. GIST usually locates under the mucosa of the stomach, esophagus, small intestine, colorectal intestine and evenly sometimes at the mesentery, omentum. Microscopically, GIST appeares as various features. In order to determine the origin of the tumor cell, surgical pathology especially the immunohistochemistry play a key role for the best choice of treatment with the targeted therapy. Objectives: - To study some of the common characteristics of the surgical pathology and immunohistochemistry of GIST. – To apply the GIST Risk Stratification of AFIP 2006 and determine the relation with some of the traditional risk factors. Materials and Method: cross-sectional study of 39 patients diagnosed with GIST at Hue Central Hospital from 6/2011 to 7/2015. Results: the average age 55.87±11.91, the most frequent age 41-60 in both men and women. The tumor size >2-5cm was the most rate 64.1%, GIST mostly located at the stomach, accounting for 48.7%. The spindle cell GISTs were the highest type 87.2%. Immunohistochemistry shown that the positive of CD117, Vimentine, CD34 were 100%, 94.7% and 61.5% respectively. All GISTs were negative for Desmine. The high risk GISTs were the most frequent accounting for 46.2%, following the moderate ones 28.2%, then the low 20.5%, the very low only 5.1%. This study also shown that, there were the relation between the tumor risk level with the tumor necrosis and the mucosa invasion. Conclusion: The application of the Immunohistochemistry with the marker CD117 and the GIST Risk Stratification need carry out for the digestive mesenchymal tumors to choose the best treatment for the patients. Key words: gastrointestinal stromal tumor (GIST), mesenchymal tumor, histopathology, immunohistochemistry

scholarly journals Endothelial glycocalyx and cardio-renal risk factors in type 1 diabetes

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254859
Author(s):  
Elisabeth Buur Stougaard ◽  
Signe Abitz Winther ◽  
Hanan Amadid ◽  
Marie Frimodt-Møller ◽  
Frederik Persson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Risk Stratification ◽  
Boundary Region ◽  
Cross Sectional Study ◽  
Endothelial Glycocalyx ◽  
Capillary Endothelium ◽  
Microvascular Damage ◽  
Cross Sectional

Background Glycocalyx lines the inner surface of the capillary endothelium. Capillaroscopy enables visualization of the sublingual capillaries and measurement of the Perfused Boundary Region (PBR) as an estimate of the glycocalyx. Novel software enables assessment of the PBR estimated at a fixed high flow level (PBR-hf) and an overall microvascular assessment by the MicroVascular Health Score (MVHS). Damaged glycocalyx may represent microvascular damage in diabetes and assessment of its dimension might improve early cardio-renal risk stratification. Aim To assess the associations between PBR, PBR-hf and MVHS and cardio-renal risk factors in persons with type 1 diabetes (T1D); and to compare these dimensions in persons with T1D and controls. Methods Cross-sectional study including 161 persons with T1D stratified according to level of albuminuria and 50 healthy controls. The PBR, PBR-hf and MVHS were assessed by the GlycoCheck device (valid measurements were available in 136 (84.5%) with T1D and in all the controls). Higher PBR and PBR-hf indicate smaller glycocalyx width. Lower MVHS represents a worse microvascular health. Results There were no associations between PBR, PBR-hf or MVHS and the cardio-renal risk factors in persons with T1D, except for higher PBR-hf and lower MVHS in females (p = 0.01 for both). There was no difference in PBR, PBR-hf or MVHS in persons with normo-, micro- or macroalbuminuria. The PBR was higher (2.20±0.30 vs. 2.03±0.18μm; p<0.001) and MVHS lower (3.15±1.25 vs. 3.53±0.86μm; p = 0.02) in persons with T1D compared to controls (p≤0.02). After adjustment for cardio-renal risk factors the difference in PBR remained significant (p = 0.001). Conclusions The endothelial glycocalyx dimension was impaired in persons with T1D compared to controls. We found no association between the endothelial glycocalyx dimension and the level of albuminuria or cardio-renal risk factors among persons with T1D. The use of the GlycoCheck device in T1D may not contribute to cardio-renal risk stratification.

PRRSV: Risikofaktoren und Herdenprävalenz in Deutschland

2019 ◽  
Vol 47 (02) ◽  
pp. 132-132
Author(s):  
Sebastian Ganz
Keyword(s):  
Risk Factors ◽  
Cross Sectional Study ◽  
Respiratory Syndrome Virus ◽  
Sectional Study ◽  
Cross Sectional ◽  
Klinische Symptome

Nathues C, Janssen E, Duengelhoef A et al. Cross-sectional study on risk factors for Porcine Reproductive and Respiratory Syndrome virus sow herd instability in German breeding herds. Acta Vet Scand 2018; 60 (1): 1–8 In mit PRRSV (Porcine Reproductive and Respiratory Syndrom Virus) infizierten Schweinebeständen zeigen die Tiere oftmals ernsthafte klinische Symptome. Die Schwere der Symptomatik hängt von der Virulenz der jeweiligen Virusstämme ab. Deshalb ist die Impfung gegen diesen Erreger sinnvoll und wird empfohlen, auch wenn sie nicht immer klinische Fälle verhindert bzw. das Virus vollends eliminiert. Aufgrund dessen rückt die Prävention durch Verbesserung der innerbetrieblichen Abläufe zunehmend in den Fokus. Um solche Maßnahmen erfolgreich etablieren zu können, ist es wichtig, den epidemiologischen Status der Herde und mögliche Risikofaktoren zu kennen. Ziel der Studie war deshalb, die Prävalenz der Infektion in Sauenbetrieben in Norddeutschland zu eruieren und verschiedene Arbeitsabläufe hinsichtlich des Risikos der Erregerverbreitung zu untersuchen.

Obesity in relation to risk factors and socioeconomic conditions among school-age children at Khartoum State 2011/2012

2019 ◽  
Vol 9 (5) ◽  
pp. 413-416
Author(s):  
Dr. Suzan Ail Yousif Abo* ,Dr. ALI abdalazez Salih
Keyword(s):  
Risk Factors ◽  
Cross Sectional Study ◽  
School Age Children ◽  
Anthropometric Measurement ◽  
Socioeconomic Conditions ◽  
Cross Sectional ◽  
School Year ◽  
Prevalence Of Obesity ◽  
Class Room ◽  
Watching Tv

This is a descriptive cross-sectional study that was carried out at Khartoum Stateduring the school year 20112/2012 to estimate the prevalence of obesity among schoolchildren aged 6-15 years and to investigate the relationship between BMI (Body MassIndex) and socioeconomic status and life style factors. Two hundred and fifty pupilsparticipated in this study. The researcher took the anthropometric measurement insidethe class room and gave the questionnaire the students to be answered by one of child’sparents. The data was analyzed using the Statistical Package for the Social Sciences(SPSS Version 13.0).In this study, prevalence of obesity was found to be (48%) of them 18% males and 30%females. Income of the family, number of high caloric carbonated beverages/week, wayof transportation to school, length of daily playing outside the home, and time spentin watching TV and video games were significantly correlated with student’s BMI.While parent’s BMI was not having significant correlation with student’s BMI.This study is considered as the first study in its field regarding this age category inKhartoum State, and it is promoting future researches in obesity and its determinant.Key words: Obesity in relation to risk factors and socioeconomic conditions amongschool-age children

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