scholarly journals Tumor-Specific Fluorescence Antibody Imaging Enables Accurate Staging Laparoscopy in an Orthotopic Model of Pancreatic Cancer

2011 ◽  
Author(s):  
Hop S Tran Cao ◽  
Sharmeela Kaushal ◽  
Cristina A Metildi ◽  
Rhiana S Menen ◽  
Claudia Lee ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Staging Laparoscopy ◽  
Orthotopic Model ◽  
Specific Fluorescence ◽  
Accurate Staging ◽  
Antibody Imaging ◽  
Fluorescence Antibody

scholarly journals Anticancer Effect of Heparin–Taurocholate Conjugate on Orthotopically Induced Exocrine and Endocrine Pancreatic Cancer

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5775
Author(s):  
Hae Hyun Hwang ◽  
Hee Jeong Jeong ◽  
Sangwu Yun ◽  
Youngro Byun ◽  
Teruo Okano ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Endothelial Cells ◽  
Cancer Cells ◽  
Tumor Model ◽  
Pancreatic Neuroendocrine Tumor ◽  
Tube Formation ◽  
Ductal Adenocarcinoma ◽  
Orthotopic Model ◽  
Anticancer Efficacy

Pancreatic cancers are classified based on where they occur, and are grouped into those derived from exocrine and those derived from neuroendocrine tumors, thereby experiencing different anticancer effects under medication. Therefore, it is necessary to develop anticancer drugs that can inhibit both types. To this end, we developed a heparin–taurocholate conjugate, i.e., LHT, to suppress tumor growth via its antiangiogenic activity. Here, we conducted a study to determine the anticancer efficacy of LHT on pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine tumor (PNET), in an orthotopic animal model. LHT reduced not only proliferation of cancer cells, but also attenuated the production of VEGF through ERK dephosphorylation. LHT effectively reduced the migration, invasion and tube formation of endothelial cells via dephosphorylation of VEGFR, ERK1/2, and FAK protein. Especially, these effects of LHT were much stronger on PNET (RINm cells) than PDAC (PANC1 and MIA PaCa-2 cells). Eventually, LHT reduced ~50% of the tumor weights and tumor volumes of all three cancer cells in the orthotopic model, via antiproliferation of cancer cells and antiangiogenesis of endothelial cells. Interestingly, LHT had a more dominant effect in the PNET-induced tumor model than in PDAC in vivo. Collectively, these findings demonstrated that LHT could be a potential antipancreatic cancer medication, regardless of pancreatic cancer types.

TUMOR-ASSOCIATED PANCREATIC STELLATE CELLS STIMULATE ANGIOGENESIS IN VITRO AND IN AN ORTHOTOPIC MODEL OF PANCREATIC CANCER

Pancreas ◽  
2008 ◽  
Vol 37 (4) ◽  
pp. 492
Author(s):  
A. Rivera ◽  
T. Moore ◽  
V. Ramachandran ◽  
T. Arumugam ◽  
C. D. Logsdon ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells ◽  
Orthotopic Model

Indication for staging laparoscopy for patients with pancreatic cancer

Pancreatology ◽  
2013 ◽  
Vol 13 (4) ◽  
pp. S41
Author(s):  
Takashi Murakami ◽  
Ryutaro Mori ◽  
Kazunori Nojiri ◽  
Takafumi Kumamoto ◽  
Ryusei Matsuyama ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Staging Laparoscopy

Survival efficacy of adjuvant cytosine-analog CS-682 in a fluorescent orthotopic model of human pancreatic cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 2077-2077
Author(s):  
M. Katz ◽  
M. Bouvet ◽  
S. Takimoto ◽  
D. Spivack ◽  
A. Moossa ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Human Pancreatic Cancer ◽  
Orthotopic Model

scholarly journals Metronomic Gemcitabine in Combination with Sunitinib Inhibits Multisite Metastasis and Increases Survival in an Orthotopic Model of Pancreatic Cancer

2010 ◽  
Vol 9 (7) ◽  
pp. 2068-2078 ◽  
Author(s):  
Hop S. Tran Cao ◽  
Michael Bouvet ◽  
Sharmeela Kaushal ◽  
Alex Keleman ◽  
Eric Romney ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Orthotopic Model

Staging laparoscopy for pancreatic cancer should be used to select the best palliation, not to increase resection rate

1998 ◽  
Vol 114 ◽  
pp. A1407 ◽  
Author(s):  
E Luque-de León ◽  
GG Tsiotos ◽  
BM Balsiger ◽  
J Barnwell ◽  
L Burgart ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Staging Laparoscopy ◽  
Resection Rate

scholarly journals Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model

2016 ◽  
Vol 107 (8) ◽  
pp. 1151-1158 ◽  
Author(s):  
Ngoc Thi Hong Hoang ◽  
Tetsuya Kadonosono ◽  
Takahiro Kuchimaru ◽  
Shinae Kizaka-Kondoh
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Survival ◽  
Hypoxia Inducible Factor ◽  
Orthotopic Model
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