scholarly journals Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model

2016 ◽  
Vol 107 (8) ◽  
pp. 1151-1158 ◽  
Author(s):  
Ngoc Thi Hong Hoang ◽  
Tetsuya Kadonosono ◽  
Takahiro Kuchimaru ◽  
Shinae Kizaka-Kondoh
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Survival ◽  
Hypoxia Inducible Factor ◽  
Orthotopic Model

miR-125b enhances metastasis and progression of cancer via the TXNIP and HIF1α pathway in pancreatic cancer

2021 ◽  
pp. 1-12
Author(s):  
Pengli Wang ◽  
Dan Zheng ◽  
Hongyang Qi ◽  
Qi Gao
Keyword(s):  
Pancreatic Cancer ◽  
Hypoxia Inducible Factor ◽  
Immunofluorescence Assay ◽  
Luciferase Assay ◽  
Interacting Protein ◽  
Over Expression ◽  
Thioredoxin Interacting Protein ◽  
Cellular Processes ◽  
And Migration

BACKGROUND: MicroRNAs (miRNAs) play potential role in the development of various types of cancer conditions including pancreatic cancer (PC) targeting several cellular processes. Present study was aimed to evaluate function of miR-125b and the mechanism involved in PC. METHODS: Cell migration, MTT and BrdU study was done to establish the migration capability, cell viability and cell proliferation respectively. Binding sites for miR-125b were recognized by luciferase assay, expression of protein by western blot and immunofluorescence assay. In vivo study was done by BALB/c nude xenograft mice for evaluating the function of miR-125b. RESULTS: The study showed that expression of miR-125b was elevated in PC cells and tissues, and was correlated to proliferation and migration of cells. Also, over-expression of miR-125b encouraged migration, metastasis and proliferation of BxPC-3 cells, the suppression reversed it. We also noticed that thioredoxin-interacting protein (TXNIP) was the potential target of miR-125b. The outcomes also suggested that miR-125b governed the expression of TXNIP inversely via directly attaching to the 3′-UTR activating hypoxia-inducible factor 1α (HIF1α). Looking into the relation between HIF1α and TXNIP, we discovered that TXNIP caused the degradation and export of HIF1α by making a complex with it. CONCLUSION: The miR-125b-TXNIP-HIF1α pathway may serve useful strategy for diagnosing and treating PC.

scholarly journals Marital status independently predicts pancreatic cancer survival in patients treated with surgical resection: an analysis of the SEER database

Oncotarget ◽  
2016 ◽  
Vol 7 (17) ◽  
pp. 24880-24887 ◽  
Author(s):  
Xiao-Dong Wang ◽  
Jian-Jun Qian ◽  
Dou-Sheng Bai ◽  
Zhen-Nan Li ◽  
Guo-Qing Jiang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Marital Status ◽  
Surgical Resection ◽  
Cancer Survival ◽  
Seer Database

scholarly journals Anticancer Effect of Heparin–Taurocholate Conjugate on Orthotopically Induced Exocrine and Endocrine Pancreatic Cancer

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5775
Author(s):  
Hae Hyun Hwang ◽  
Hee Jeong Jeong ◽  
Sangwu Yun ◽  
Youngro Byun ◽  
Teruo Okano ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Endothelial Cells ◽  
Cancer Cells ◽  
Tumor Model ◽  
Pancreatic Neuroendocrine Tumor ◽  
Tube Formation ◽  
Ductal Adenocarcinoma ◽  
Orthotopic Model ◽  
Anticancer Efficacy

Pancreatic cancers are classified based on where they occur, and are grouped into those derived from exocrine and those derived from neuroendocrine tumors, thereby experiencing different anticancer effects under medication. Therefore, it is necessary to develop anticancer drugs that can inhibit both types. To this end, we developed a heparin–taurocholate conjugate, i.e., LHT, to suppress tumor growth via its antiangiogenic activity. Here, we conducted a study to determine the anticancer efficacy of LHT on pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine tumor (PNET), in an orthotopic animal model. LHT reduced not only proliferation of cancer cells, but also attenuated the production of VEGF through ERK dephosphorylation. LHT effectively reduced the migration, invasion and tube formation of endothelial cells via dephosphorylation of VEGFR, ERK1/2, and FAK protein. Especially, these effects of LHT were much stronger on PNET (RINm cells) than PDAC (PANC1 and MIA PaCa-2 cells). Eventually, LHT reduced ~50% of the tumor weights and tumor volumes of all three cancer cells in the orthotopic model, via antiproliferation of cancer cells and antiangiogenesis of endothelial cells. Interestingly, LHT had a more dominant effect in the PNET-induced tumor model than in PDAC in vivo. Collectively, these findings demonstrated that LHT could be a potential antipancreatic cancer medication, regardless of pancreatic cancer types.

scholarly journals Extracellular superoxide dismutase suppresses hypoxia-inducible factor-1α in pancreatic cancer

2014 ◽  
Vol 69 ◽  
pp. 357-366 ◽  
Author(s):  
Zita A. Sibenaller ◽  
Jessemae L. Welsh ◽  
Changbin Du ◽  
Jordan R. Witmer ◽  
Hannah E. Schrock ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Superoxide Dismutase ◽  
Hypoxia Inducible Factor ◽  
Extracellular Superoxide Dismutase ◽  
Hypoxia Inducible Factor 1Α

Cancer Survival Is (Mostly) Improving

Pained ◽  
2020 ◽  
pp. 245-246
Author(s):  
Michael D. Stein ◽  
Sandro Galea
Keyword(s):  
Prostate Cancer ◽  
United States ◽  
Pancreatic Cancer ◽  
Survival Rate ◽  
Cancer Diagnosis ◽  
Cancer Survival ◽  
Prostate Cancer Screening ◽  
Survival Rates ◽  
The United States ◽  
Cervical Cancers

This chapter discusses how the 5-year survival rates for the most common cancers in the United States improved by nearly 20% since the 1970s. While promising overall, low survival rates persist for pancreatic, liver, lung, esophageal, brain, and many other cancers. Meanwhile, 5-year survival for uterine and cervical cancers worsened. Pancreatic cancer has the lowest 5-year survival rate at 8.2%. In contrast, prostate cancer had the greatest 5-year survival increase from 67.8% to 98.6%, most likely reflecting a substantial uptick in prostate cancer screening and early detection. Five-year survival with leukemia also improved significantly, from 34.2% to 60.6%, likely resulting from improved treatments. As such, in both detection and treatment, the United States is making progress. For the millions of Americans who face a cancer diagnosis, this is cause for hope.

Hypoxia inducible factor (HIF)-1α directly activates leptin receptor (Ob-R) in pancreatic cancer cells

2014 ◽  
Vol 354 (1) ◽  
pp. 172-180 ◽  
Author(s):  
He Ren ◽  
Lingling Jia ◽  
Tiansuo Zhao ◽  
Huan Zhang ◽  
Jing Chen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Leptin Receptor ◽  
Hypoxia Inducible Factor ◽  
Pancreatic Cancer Cells

scholarly journals Geographical residency influences pancreatic cancer survival: a Danish nationwide population-based cohort study

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S533
Author(s):  
J. Kirkegård ◽  
M. Ladekarl ◽  
C.W. Fristrup ◽  
C. Palnæs-Hansen ◽  
M. Sall ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cohort Study ◽  
Cancer Survival ◽  
Population Based
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