Oncolytic Herpes Virus Induces Effective Anti-Cancer Immunity against Murine Colon Cancer

2011 ◽  
Vol 58 (110-111) ◽  
Author(s):  
Takashi Shirota ◽  
Hideki Kasuya ◽  
Yasuhiro Kodera ◽  
Yoko Nishikawa ◽  
Toshio Shikano ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Herpes Virus ◽  
Cancer Immunity ◽  
Anti Cancer ◽  
Herpès Virus ◽  
Murine Colon

Co-operation of α-galactosylceramide-loaded tumour cells and TLR9 agonists induce potent anti-tumour responses in a murine colon cancer model

2015 ◽  
Vol 473 (1) ◽  
pp. 7-19 ◽  
Author(s):  
Tiangeng Dong ◽  
Tuo Yi ◽  
Mengxuan Yang ◽  
Shengli Lin ◽  
Wenxiang Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumour Cells ◽  
Toll Like Receptor ◽  
Cancer Model ◽  
Cancer Vaccination ◽  
Tlr9 Agonist ◽  
Broad Applicability ◽  
Human Cancers ◽  
Anti Cancer ◽  
Murine Colon

This is the first demonstration that α-galactosylceramide (α-Galcer)-loaded tumour cells (tumour–Gal) plus the Toll-like receptor 9 (TLR9) agonist as therapeutic anti-cancer vaccination. This strategy may have broad applicability and lead to development of effective immunotherapy against various human cancers.

scholarly journals Human amniotic epithelial cells exert anti-cancer effects through secretion of immunomodulatory exosomes

2021 ◽  
Author(s):  
Mohammad Bolouri ◽  
Roya Ghods ◽  
sedighe vafaei ◽  
Reza Falak ◽  
Amir-Hassan Zarnani
Keyword(s):  
Colon Cancer ◽  
Tumor Cells ◽  
Tumor Development ◽  
Inhibitory Effects ◽  
Anti Cancer ◽  
Human Amniotic Epithelial Cells ◽  
4T1 Cells ◽  
Induced Apoptosis ◽  
Murine Colon ◽  
Reactive Antibody

We identified here mechanism by which hAEC exert their anti-cancer effects. We showed that vaccination with live hAEC conferred effective protection against murine colon cancer and melanoma but not against breast cancer in orthotopic cancer cell inoculation model. hAEC induced strong cross-reactive antibody response to CT26 cells, but not against B16F10 and 4T1 cells. Neither heterotopic injection of tumor cells in AEC-vaccinated mice nor vaccination with hAEC lysate conferred protection against melanoma or colon cancer. Nanosized AEC-derived exosomes (ADE) induced apoptosis in CT26 cells and inhibited their proliferation. Co-administration of ADE with tumor cells substantially inhibited tumor development and increased CTL responses in vaccinated mice. Our results clearly showed that it is ADE but not the cross-reactive immune responses against tumor cells that mediate inhibitory effects of hAEC on cancer development. Our results highlighted the potential anti-cancer effects of exosomes derived from hAEC.

scholarly journals Enhancement of anti-murine colon cancer immunity by fusion of a SARS fragment to a low-immunogenic carcinoembryonic antigen

2012 ◽  
Vol 14 (1) ◽  
pp. 2 ◽  
Author(s):  
Chen-Si Lin ◽  
Shih-Han Kao ◽  
Yu-Cheng Chen ◽  
Chi-Han Li ◽  
Yuan-Ting Hsieh ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Carcinoembryonic Antigen ◽  
Cancer Immunity ◽  
Murine Colon
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