Co-operation of α-galactosylceramide-loaded tumour cells and TLR9 agonists induce potent anti-tumour responses in a murine colon cancer model

2015 ◽  
Vol 473 (1) ◽  
pp. 7-19 ◽  
Author(s):  
Tiangeng Dong ◽  
Tuo Yi ◽  
Mengxuan Yang ◽  
Shengli Lin ◽  
Wenxiang Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumour Cells ◽  
Toll Like Receptor ◽  
Cancer Model ◽  
Cancer Vaccination ◽  
Tlr9 Agonist ◽  
Broad Applicability ◽  
Human Cancers ◽  
Anti Cancer ◽  
Murine Colon

This is the first demonstration that α-galactosylceramide (α-Galcer)-loaded tumour cells (tumour–Gal) plus the Toll-like receptor 9 (TLR9) agonist as therapeutic anti-cancer vaccination. This strategy may have broad applicability and lead to development of effective immunotherapy against various human cancers.

Oncolytic Herpes Virus Induces Effective Anti-Cancer Immunity against Murine Colon Cancer

2011 ◽  
Vol 58 (110-111) ◽  
Author(s):  
Takashi Shirota ◽  
Hideki Kasuya ◽  
Yasuhiro Kodera ◽  
Yoko Nishikawa ◽  
Toshio Shikano ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Herpes Virus ◽  
Cancer Immunity ◽  
Anti Cancer ◽  
Herpès Virus ◽  
Murine Colon

scholarly journals Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model

2010 ◽  
Vol 101 (11) ◽  
pp. 2325-2332 ◽  
Author(s):  
Yuan Wen ◽  
Chun-Ting Wang ◽  
Tian-Tai Ma ◽  
Zhi-Yong Li ◽  
Li-Na Zhou ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Growth ◽  
Fibroblast Activation Protein ◽  
Cancer Model ◽  
Fibroblast Activation ◽  
Murine Colon

scholarly journals Development of a metastatic murine colon cancer model

2015 ◽  
Vol 199 (1) ◽  
pp. 106-114 ◽  
Author(s):  
Krista P. Terracina ◽  
Tomoyoshi Aoyagi ◽  
Wei-Ching Huang ◽  
Masayuki Nagahashi ◽  
Akimitsu Yamada ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Model ◽  
Murine Colon

scholarly journals Comparative Expression of P53 and Survivin Proteins in Phenylhydrazine-Induced Colon Cancer of Rats and the Role of Electromagnetic Field and Broccoli Extract

2021 ◽  
Author(s):  
Aziz Awaad ◽  
Mohamed A. Adly ◽  
Medhat A. Abd ellatef ◽  
Moshira M. Foad
Keyword(s):  
Colon Cancer ◽  
Electromagnetic Field ◽  
Combined Therapy ◽  
Low Frequency ◽  
Survivin Expression ◽  
Cancer Model ◽  
Beneficial Effects ◽  
Anti Cancer

Abstract Cancer constitutes as one of the most serious causes of death worldwide. For example, colon cancer is the second-most dangerous type of cancer, affecting both men and women. Recently, the application of electromagnetic field (EMF) in the treatment of cancer whether alone or in combination with other anti-cancer materials seems to be a promising therapy. Furthermore, broccoli extract which is rich with sulforaphane (sulfur-rich compound) previously used as one of anti-cancer materials. In this context, the current study aimed to investigate the potential beneficial effects of extremely low frequency-EMF (ELF-EMF) application alone and in combination with broccoli extract in the treatment and protection from cancer in phenylhydrazine (PHZ)-induced colon cancer model. To achieve our aims, the histolopathological abnormalities were investigated histologically and the comparative expression of P53 and survivin proteins were investigated immunohistochemically. This report revealed that PHZ injection was able to induce carcinogenicity in the large intestine of rats especially colon. The PHZ-injected group showed abnormal, biochemical, histological and immunohistochemical parameters. Histologically, the treated colon showed high-grade dysplastic lesions that are further considered as carcinoma-in-situ. The expression of P53 in the crypt of colon decreased significantly in the epithelial cells and lamina propria stroma. Contradictory, survivin expression increased in the same regions after animal exposed to PHZ. However, exposure of PHZ-injected animals to ELF-EMF or broccoli extract separately didn't ameliorate the abnormalities produced by PHZ completely. Interestingly, the combination between ELF-EMF and broccoli extract significantly mitigated the effects of PHZ and succeeded in suppressing tumor progression and normalize the expression of P53 and survivin expressions. This study provided important information about expression of important proteins during cancer stages and the role of combined therapy using EMFs and broccoli extract. Furthermore, the expression changes of P53 and survivin proteins might be used as markers in cancer diagnosis and treatment progress.

Angiocidin Inhibitory Peptides Decrease Tumor Burden in a Murine Colon Cancer Model

2007 ◽  
Vol 142 (2) ◽  
pp. 320-326 ◽  
Author(s):  
Catherine Liebig ◽  
Neeti Agarwal ◽  
Gustavo E. Ayala ◽  
Gordana Verstovsek ◽  
George P. Tuszynski ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Burden ◽  
Cancer Model ◽  
Inhibitory Peptides ◽  
Murine Colon
Sign in / Sign up

Export Citation Format

Share Document