scholarly journals Detection of Mendelian and Parent-of-origin Quantitative Trait Loci in a Cross between Korean Native Pig and Landrace I. Growth and Body Composition Traits

2007 ◽  
Vol 20 (5) ◽  
pp. 669-676 ◽  
Author(s):  
E. H. Kim ◽  
B. H. Choi ◽  
K. S. Kim ◽  
C. K. Lee ◽  
B. W. Cho ◽  
...  
Keyword(s):  
Body Composition ◽  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Trait Loci ◽  
Korean Native Pig ◽  
Parent Of Origin

Two Powerful Tests for Parent-of-Origin Effects at Quantitative Trait Loci on the X Chromosome

2018 ◽  
Vol 83 (5) ◽  
pp. 250-273
Author(s):  
Pui Yin Lau ◽  
Kar Fu Yeung ◽  
Ji-Yuan Zhou ◽  
Wing Kam Fung
Keyword(s):  
Quantitative Trait Loci ◽  
X Chromosome ◽  
Quantitative Trait ◽  
Trait Loci ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Quantitative trait loci with parent-of-origin effects in chicken

2004 ◽  
Vol 84 (1) ◽  
pp. 57-66 ◽  
Author(s):  
MARIA TUISKULA-HAAVISTO ◽  
DIRK-JAN DE KONING ◽  
MERVI HONKATUKIA ◽  
NINA F. SCHULMAN ◽  
ASKO MÄKI-TANILA ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Trait Loci ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss

2014 ◽  
Author(s):  
Larry Leamy ◽  
Kari Elo ◽  
Merlyn K Nielsen ◽  
Stephanie Thorn ◽  
William Valdar ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Quantitative Trait Loci ◽  
Energy Balance ◽  
Heat Loss ◽  
Quantitative Trait ◽  
Parameter Analysis ◽  
Chromosome 1 ◽  
Health Concern ◽  
Trait Loci

Obesity in human populations, currently a serious health concern, is considered to be the consequence of an energy imbalance in which more energy in calories is consumed than is expended. We used interval mapping techniques to investigate the genetic basis of a number of energy balance traits in an F11 advanced intercross population of mice created from an original intercross of lines selected for increased and decreased heat loss. We uncovered a total of 137 quantitative trait loci (QTLs) for these traits at 41 unique sites on 18 of the 20 chromosomes in the mouse genome, with X-linked QTLs being most prevalent. Two QTLs were found for the selection target of heat loss, one on distal chromosome 1 and another on proximal chromosome 2. The number of QTLs affecting the various traits generally was consistent with previous estimates of heritabilities in the same population, with the most found for two bone mineral traits and the least for feed intake and several body composition traits. QTLs were generally additive in their effects, and some, especially those affecting the body weight traits, were sex-specific. Pleiotropy was extensive within trait groups (body weights, adiposity and organ weight traits, bone traits) and especially between body composition traits adjusted and not adjusted for body weight at sacrifice. Nine QTLs were found for one or more of the adiposity traits, five of which appeared to be unique. The confidence intervals among all QTLs averaged 13.3 Mb, much smaller than usually observed in an F2 cross, and in some cases this allowed us to make reasonable inferences about candidate genes underlying these QTLs. This study combined QTL mapping with genetic parameter analysis in a large segregating population, and has advanced our understanding of the genetic architecture of complex traits related to obesity.

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