scholarly journals Identification of quantitative trait loci affecting body composition in a mouse intercross

2006 ◽  
Vol 103 (52) ◽  
pp. 19860-19865 ◽  
Author(s):  
J. A. Vitarius ◽  
E. Sehayek ◽  
J. L. Breslow
Keyword(s):  
Body Composition ◽  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Trait Loci

scholarly journals Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss

2014 ◽  
Author(s):  
Larry Leamy ◽  
Kari Elo ◽  
Merlyn K Nielsen ◽  
Stephanie Thorn ◽  
William Valdar ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Quantitative Trait Loci ◽  
Energy Balance ◽  
Heat Loss ◽  
Quantitative Trait ◽  
Parameter Analysis ◽  
Chromosome 1 ◽  
Health Concern ◽  
Trait Loci

Obesity in human populations, currently a serious health concern, is considered to be the consequence of an energy imbalance in which more energy in calories is consumed than is expended. We used interval mapping techniques to investigate the genetic basis of a number of energy balance traits in an F11 advanced intercross population of mice created from an original intercross of lines selected for increased and decreased heat loss. We uncovered a total of 137 quantitative trait loci (QTLs) for these traits at 41 unique sites on 18 of the 20 chromosomes in the mouse genome, with X-linked QTLs being most prevalent. Two QTLs were found for the selection target of heat loss, one on distal chromosome 1 and another on proximal chromosome 2. The number of QTLs affecting the various traits generally was consistent with previous estimates of heritabilities in the same population, with the most found for two bone mineral traits and the least for feed intake and several body composition traits. QTLs were generally additive in their effects, and some, especially those affecting the body weight traits, were sex-specific. Pleiotropy was extensive within trait groups (body weights, adiposity and organ weight traits, bone traits) and especially between body composition traits adjusted and not adjusted for body weight at sacrifice. Nine QTLs were found for one or more of the adiposity traits, five of which appeared to be unique. The confidence intervals among all QTLs averaged 13.3 Mb, much smaller than usually observed in an F2 cross, and in some cases this allowed us to make reasonable inferences about candidate genes underlying these QTLs. This study combined QTL mapping with genetic parameter analysis in a large segregating population, and has advanced our understanding of the genetic architecture of complex traits related to obesity.

scholarly journals Quantitative trait loci for energy balance traits in an advanced intercross line derived from mice divergently selected for heat loss

2014 ◽  
Author(s):  
Larry Leamy ◽  
Kari Elo ◽  
Merlyn K Nielsen ◽  
Stephanie Thorn ◽  
William Valdar ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Quantitative Trait Loci ◽  
Energy Balance ◽  
Heat Loss ◽  
Quantitative Trait ◽  
Parameter Analysis ◽  
Chromosome 1 ◽  
Health Concern ◽  
Trait Loci

Obesity in human populations, currently a serious health concern, is considered to be the consequence of an energy imbalance in which more energy in calories is consumed than is expended. We used interval mapping techniques to investigate the genetic basis of a number of energy balance traits in an F11 advanced intercross population of mice created from an original intercross of lines selected for increased and decreased heat loss. We uncovered a total of 137 quantitative trait loci (QTLs) for these traits at 41 unique sites on 18 of the 20 chromosomes in the mouse genome, with X-linked QTLs being most prevalent. Two QTLs were found for the selection target of heat loss, one on distal chromosome 1 and another on proximal chromosome 2. The number of QTLs affecting the various traits generally was consistent with previous estimates of heritabilities in the same population, with the most found for two bone mineral traits and the least for feed intake and several body composition traits. QTLs were generally additive in their effects, and some, especially those affecting the body weight traits, were sex-specific. Pleiotropy was extensive within trait groups (body weights, adiposity and organ weight traits, bone traits) and especially between body composition traits adjusted and not adjusted for body weight at sacrifice. Nine QTLs were found for one or more of the adiposity traits, five of which appeared to be unique. The confidence intervals among all QTLs averaged 13.3 Mb, much smaller than usually observed in an F2 cross, and in some cases this allowed us to make reasonable inferences about candidate genes underlying these QTLs. This study combined QTL mapping with genetic parameter analysis in a large segregating population, and has advanced our understanding of the genetic architecture of complex traits related to obesity.

Mapping quantitative trait loci regulating chicken body composition traits

2009 ◽  
Vol 40 (6) ◽  
pp. 952-954 ◽  
Author(s):  
Y. Gao ◽  
Z. Q. Du ◽  
W. H. Wei ◽  
X. J. Yu ◽  
X. M. Deng ◽  
...  
Keyword(s):  
Body Composition ◽  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Trait Loci

Novel quantitative trait loci for chemical body composition traits in pigs

2007 ◽  
Vol 2007 ◽  
pp. 3-3
Author(s):  
C. Duthie ◽  
G. Simm ◽  
P. Knap ◽  
A. Wilson ◽  
E. Kalm ◽  
...  
Keyword(s):  
Body Composition ◽  
Quantitative Trait Loci ◽  
Food Intake ◽  
Quantitative Trait ◽  
Nutritional Requirements ◽  
Economic Interest ◽  
Fat Tissue ◽  
Trait Loci ◽  
Genomic Regulation ◽  
Physical And Chemical

Quantitative trait loci (QTL) associated with physical and chemical body composition of the pig are of substantial economic interest. Previous studies have reported QTL for physical body composition such as lean and fat tissue traits (Roehe et al., 2003). In contrast, QTL associated with chemical body composition and for the change in deposition of such components during growth have only been reported in one previous study (Mohrmann et al., 2006). Knowledge of the genomic regulation of body composition during growth is important to accurately estimate nutritional requirements, optimise the entire production system, characterise the population of interest, and to optimise food intake capacity by breeding.

Novel epistatic QTL for chemical body composition and accretion as well as feed efficiency in pigs

2009 ◽  
Vol 2009 ◽  
pp. 39-39
Author(s):  
C-A Duthie ◽  
G Simm ◽  
A Doeschl-Wilson ◽  
E Kalm ◽  
P Knap ◽  
...  
Keyword(s):  
Body Composition ◽  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Feed Efficiency ◽  
Epistatic Qtl ◽  
Trait Loci ◽  
Genomic Regulation ◽  
Regulation Of Growth ◽  
Qtl Effects

Most quantitative trait loci (QTL) studies have focussed on the identification of individual QTL effects (additive, dominance and imprinting) in the absence of interactions (epistasis). There are numerous reports in the literature for QTL associated with growth and body composition of pigs, however much less effort has focussed around the identification of epistatic QTL for these traits. Growth and body composition of pigs are probably influenced by numerous QTL located throughout the genome as well as interactions between QTL. Therefore the objective of this study was to investigate the contribution of epistasis to the genomic regulation of growth and body composition of pigs.

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