scholarly journals Exercise induced upregulation of glutamate-cysteine ligase catalytic subunit and glutamate-cysteine ligase modifier subunit gene expression in Thoroughbred horses

2017 ◽  
Vol 30 (5) ◽  
pp. 728-735 ◽  
Author(s):  
Jeong-Woong Park ◽  
Jae-Young Choi ◽  
Seul A Hong ◽  
Nam Young Kim ◽  
Kyoung-Tag Do ◽  
...  
Keyword(s):  
Gene Expression ◽  
Catalytic Subunit ◽  
Subunit Gene ◽  
Glutamate Cysteine Ligase ◽  
Thoroughbred Horses ◽  
Exercise Induced

scholarly journals Transcriptional activation of DNA‐dependent protein kinase catalytic subunit gene expression by oestrogen receptor‐α

EMBO Reports ◽  
2010 ◽  
Vol 11 (3) ◽  
pp. 208-213 ◽  
Author(s):  
Senad Medunjanin ◽  
Sönke Weinert ◽  
David Poitz ◽  
Alexander Schmeisser ◽  
Ruth H Strasser ◽  
...  
Keyword(s):  
Gene Expression ◽  
Protein Kinase ◽  
Transcriptional Activation ◽  
Oestrogen Receptor ◽  
Catalytic Subunit ◽  
Subunit Gene ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Oestrogen Receptor Α

scholarly journals Distinct Nrf1/2-independent mechanisms mediate As3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes

2009 ◽  
Vol 46 (12) ◽  
pp. 1614-1625 ◽  
Author(s):  
James A. Thompson ◽  
Collin C. White ◽  
David P. Cox ◽  
Jefferson Y. Chan ◽  
Terrance J. Kavanagh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Subunit Gene ◽  
Glutamate Cysteine Ligase

scholarly journals Associations between glutamate cysteine ligase catalytic subunit gene polymorphisms and clinical characteristics of ischemic stroke

2021 ◽  
Author(s):  
YA Bocharova
Keyword(s):  
Ischemic Stroke ◽  
Age At Onset ◽  
Clinical Manifestations ◽  
Lesion Size ◽  
Catalytic Subunit ◽  
Nucleotide Polymorphisms ◽  
Cerebral Lesion ◽  
Subunit Gene ◽  
Glutamate Cysteine Ligase ◽  
Brain Tissue Damage

An imbalance between the production of reactive oxygen species and their neutralization lies at the core of oxidative stress implicated in ischemic stroke (IS) and the subsequent brain tissue damage. The aim of this study was to investigate the effects of common polymorphic variants of the glutamate cysteine ligase catalytic subunit gene on the extent of brain damage and clinical manifestations in patients with ischemic stroke. A total of 589 ischemic stroke survivors were genotyped for 6 single nucleotide polymorphisms (SNPs) of the GCLC gene, including rs12524494, rs17883901, rs606548, rs636933, rs648595 and rs761142, using a MassARRAY-4 analyzer. The study found that genotypes rs636933-G/A-A/A (р = 0.009) and rs761142-A/C-C/C (р = 0.015) were associated with an enlargement of the cerebral lesion size. Genotypes rs12524494-G/G (р = 0.05) and rs606548-T/T (р = 0.003) were associated with a risk of 2 or more IS episodes. Genotype rs17883901-G/A was associated with early onset of IS (р = 0.004). The study revealed multiple associations of GCLC SNPs with the clinical manifestations of ischemic stroke. Thus, GCLC polymorphisms are important DNA markers affecting the size of the cerebral lesion in patients with ischemic stroke and are associated with age at onset, the number of past strokes and the clinical manifestations of the disease.

Ethanol-induced expression of glutamate–cysteine ligase catalytic subunit gene is mediated by NF-κB

2009 ◽  
Vol 185 (2) ◽  
pp. 110-115 ◽  
Author(s):  
Tomoki Kimura ◽  
Yukiko Kawasaki ◽  
Fumika Okumura ◽  
Tomomichi Sone ◽  
Reiko Natsuki ◽  
...  
Keyword(s):  
Catalytic Subunit ◽  
Subunit Gene ◽  
Glutamate Cysteine Ligase ◽  
Induced Expression

scholarly journals Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction

2003 ◽  
Vol 41 (4) ◽  
pp. 539-545 ◽  
Author(s):  
Shun-ichi Koide ◽  
Kiyotaka Kugiyama ◽  
Seigo Sugiyama ◽  
Shin-ichi Nakamura ◽  
Hironobu Fukushima ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Catalytic Subunit ◽  
Subunit Gene ◽  
Glutamate Cysteine Ligase ◽  
Vasomotor Dysfunction
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