Evaluation of the Structure of Phosphate Glass Samples Using TOF-SIMS

Shio TAKAHASHI; Hiroko SHINOZAKI; Yoshihiro KANADA; Akio HANADA; Yutaka YAMAMOTO; Toru MICHIMATA

doi:10.5702/massspec.11-27

Coordinated test-rig and ToF-SIMS experiments to investigate the influence of phosphate glass layers on the friction behavior of a wet clutch

Surface and Interface Analysis ◽

10.1002/sia.5610 ◽

2014 ◽

Vol 46 (S1) ◽

pp. 401-404 ◽

Cited By ~ 5

Author(s):

C. Mayer ◽

D. Lipinsky ◽

F. Wohlleber ◽

H. Pflaum ◽

K. Stahl ◽

...

Keyword(s):

Phosphate Glass ◽

Test Rig ◽

Friction Behavior ◽

Tof Sims ◽

Wet Clutch

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Applications of Time-OF-Flight Secondary Ion Mass Spectrometry (TOF-SIMS)

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100135149 ◽

1990 ◽

Vol 48 (2) ◽

pp. 308-309

Author(s):

Bruno Schueler ◽

Robert W. Odom

Keyword(s):

Mass Spectrometry ◽

Secondary Ion Mass Spectrometry ◽

Structural Information ◽

Time Of Flight ◽

Biological Tissues ◽

Polymer Surfaces ◽

Tof Sims ◽

Secondary Ions ◽

Ion Mass Spectrometry ◽

Secondary Ion

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) provides unique capabilities for elemental and molecular compositional analysis of a wide variety of surfaces. This relatively new technique is finding increasing applications in analyses concerned with determining the chemical composition of various polymer surfaces, identifying the composition of organic and inorganic residues on surfaces and the localization of molecular or structurally significant secondary ions signals from biological tissues. TOF-SIMS analyses are typically performed under low primary ion dose (static SIMS) conditions and hence the secondary ions formed often contain significant structural information.This paper will present an overview of current TOF-SIMS instrumentation with particular emphasis on the stigmatic imaging ion microscope developed in the authors’ laboratory. This discussion will be followed by a presentation of several useful applications of the technique for the characterization of polymer surfaces and biological tissues specimens. Particular attention in these applications will focus on how the analytical problem impacts the performance requirements of the mass spectrometer and vice-versa.

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New approaches to coupling TLC with TOF-SIMS

JPC - Journal of Planar Chromatography - Modern TLC ◽

10.1556/jpc.18.2005.1.8 ◽

2005 ◽

Vol 18 (101) ◽

pp. 44-50 ◽

Cited By ~ 11

Author(s):

Andrej Oriňák ◽

Guido Vering ◽

Heinrich Arlinghaus ◽

Jan Andersson ◽

Ladislav Halas ◽

...

Keyword(s):

New Approaches ◽

Tof Sims

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Optics-Free Visualization of Proteins in Single Cells by Time of Flight-Secondary Ion Mass Spectrometry Coupled with Genetically Encoded Chemical Tags

10.26434/chemrxiv.12046125 ◽

2020 ◽

Author(s):

Feifei Jia ◽

Jie Wang ◽

Yanyan Zhang ◽

Qun Luo ◽

Luyu Qi ◽

...

Keyword(s):

Mass Spectrometry ◽

Secondary Ion Mass Spectrometry ◽

Single Cells ◽

Time Of Flight ◽

E Coli ◽

Tof Sims ◽

Ion Mass Spectrometry ◽

Chemical Tags ◽

Secondary Ion

In situ visualization of proteins of interest at single cell level is attractive in cell biology, molecular biology and biomedicine, which usually involves photon, electron or X-ray based imaging methods. Herein, we report an optics-free strategy that images a specific protein in single cells by time of flight-secondary ion mass spectrometry (ToF-SIMS) following genetic incorporation of fluorine-containing unnatural amino acids as a chemical tag into the protein via genetic code expansion technique. The method was developed and validated by imaging GFP in E. coli and human HeLa cancer cells, and then utilized to visualize the distribution of chemotaxis protein CheA in E. coli cells and the interaction between high mobility group box 1 protein and cisplatin damaged DNA in HeLa cells. The present work highlights the power of ToF-SIMS imaging combined with genetically encoded chemical tags for in situ visualization of proteins of interest as well as the interactions between proteins and drugs or drug damaged DNA in single cells.

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Studies on a Failure Analysis Flow of Surface Contamination, Corrosion, and Underetch on Microchip Al Bondpads in Wafer Fabrication

ISTFA 2005: Conference Proceedings from the 31st International Symposium for Testing and Failure Analysis ◽

10.31399/asm.cp.istfa2005p0274 ◽

2005 ◽

Author(s):

Hua Younan

Keyword(s):

Failure Analysis ◽

Galvanic Corrosion ◽

Surface Contamination ◽

Wafer Fabrication ◽

Tof Sims ◽

Corrosion Passivation

Abstract A failure analysis flow is developed for surface contamination, corrosion and underetch on microchip Al bondpads and it is applied in wafer fabrication. SEM, EDX, Auger, FTIR, XPS and TOF-SIMS are used to identify the root causes. The results from carbon related contamination, galvanic corrosion, fluorine-induced corrosion, passivation underetch and Auger bondpad monitoring will be presented. The failure analysis flow will definitely help us to select suitable methods and tools for failure analysis of Al bondpad-related issues, identify rapidly possible root causes of the failures and find the eliminating solutions at both wafer fabrication and assembly houses.

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The possibility of using tantalum oxide microparticles in phosphate glass for radiation therapy of malignant neoplasms

Pacific Medical Journal ◽

10.34215/1609-1175-2020-4-85-87 ◽

2020 ◽

pp. 85-87

Author(s):

O. S. Plotnikova ◽

V. I. Apanasevich ◽

M. A. Medkov ◽

A. A. Polezhaev ◽

V. I. Nevozhai ◽

...

Keyword(s):

Phosphate Glass ◽

Linear Accelerator ◽

Malignant Tumors ◽

Video Recording ◽

Tantalum Oxide ◽

Vertical Plane ◽

Secondary Radiation ◽

Semiconductor Diode ◽

Malignant Neoplasms ◽

Diode Detector

Objective: The creation of the medicine for a local radiomodification of tumors.Methods: The level of the secondary radiation on the surface of the phosphate glass powder with the inclusion of tantalum oxide processed by 6 MeV deceleration emission was studied. Medical linear accelerator TrueBeam (Varian, USA), and Semiconductor diode detector PDI 2.0 (Sun Nuclear Corp., USA) having the system of moving in vertical plane and the system of position video recording were used.Results: The presence of the phosphate glass (containing 20% Та2О5) on the surface gave a 63.7% increase to the secondary radiation. It’s around two thirds of the overall level.Conclusion: An opportunity to create a medicine on the basis of phosphate glass, containing tantalum oxide, for local radiomodification of malignant tumors.

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Proton Conductivity of Niobium Phosphate Glass Thin Films

Korean Journal of Materials Research ◽

10.3740/mrsk.2018.28.5.308 ◽

2018 ◽

Vol 28 (5) ◽

pp. 308-314

Author(s):

Dae Ho Kim ◽

Sung Bum Park ◽

Yong-il Park

Keyword(s):

Thin Films ◽

Proton Conductivity ◽

Phosphate Glass ◽

Niobium Phosphate

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Phosphate glass fibres with therapeutic ions release capability – a review

Advances in Applied Ceramics ◽

10.1080/17436753.2018.1564413 ◽

2019 ◽

Vol 119 (1) ◽

pp. 1-14 ◽

Cited By ~ 7

Author(s):

Agata Lapa ◽

Mark Cresswell ◽

Phil Jackson ◽

Aldo R. Boccaccini

Keyword(s):

Phosphate Glass ◽

Glass Fibres

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Development and physicochemical characterization of novel porous phosphate glass bone graft substitute and in vitro comparison with xenograft

Journal of Materials Science Materials in Medicine ◽

10.1007/s10856-021-06532-8 ◽

2021 ◽

Vol 32 (6) ◽

Author(s):

Niketa Chauhan ◽

Nilay Lakhkar ◽

Amol Chaudhari

Keyword(s):

Cell Proliferation ◽

Physicochemical Properties ◽

Bone Graft ◽

Phosphate Glass ◽

Physicochemical Characterization ◽

Bone Graft Substitute ◽

Organic Content ◽

In Vitro Cytotoxicity ◽

Porous Phosphate

AbstractThe process of bone regeneration in bone grafting procedures is greatly influenced by the physicochemical properties of the bone graft substitute. In this study, porous phosphate glass (PPG) morsels were developed and their physicochemical properties such as degradation, crystallinity, organic content, surface topography, particle size and porosity were evaluated using various analytical methods. The in vitro cytotoxicity of the PPG morsels was assessed and the interaction of the PPG morsels with Dental Pulp Stem Cells (DPSCs) was studied by measuring cell proliferation and cell penetration depth. The cell-material interactions between PPG morsels and a commercially available xenograft (XG) were compared. The PPG morsels were observed to be amorphous, biocompatible and highly porous (porosity = 58.45%). From in vitro experiments, PPG morsels were observed to be non-cytotoxic and showed better cell proliferation. The internal surface of PPG was easily accessible to the cells compared to XG.

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