Intravenous or oral iron for treating iron deficiency anaemia during pregnancy: systematic review and meta‐analysis

2019 ◽  
Vol 211 (8) ◽  
pp. 367-373 ◽  
Author(s):  
Alaa Qassim ◽  
Rosalie M Grivell ◽  
Amanda Henry ◽  
Giselle Kidson‐Gerber ◽  
Antonia Shand ◽  
...  
Keyword(s):  
Systematic Review ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Meta Analysis ◽  
Oral Iron ◽  
Deficiency Anaemia

scholarly journals Iron stores in pregnant women with sickle cell disease: a protocol for a systematic review and meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e026497 ◽  
Author(s):  
Desmond Aroke ◽  
Benjamin Momo Kadia ◽  
Tsi Njim
Keyword(s):  
Systematic Review ◽  
Sickle Cell Disease ◽  
Iron Deficiency ◽  
Pregnant Women ◽  
Sickle Cell ◽  
Iron Deficiency Anaemia ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Cell Disease ◽  
Deficiency Anaemia

IntroductionSickle cell disease (SCD) is the most common inherited disease worldwide. The greatest disease burden is seen in sub-Saharan Africa. Early diagnosis and improved care of people living with SCD have led to an increase in the number of women with SCD reaching the reproductive age. Iron deficiency anaemia remains the most common cause of anaemia in pregnancy, affecting 51%–63% of pregnancies in Africa. However, the unavailability of guidelines on supplementation of iron in this pregnant subpopulation often leaves clinicians in a fix. We propose to conduct the first systematic review and possibly a meta-analysis on the prevalence, associated factors and maternal/fetal outcomes of iron deficiency anaemia among pregnant women with SCD.Methods and analysisWe will search the following electronic databases for studies on the iron status of pregnant women with SCD: PubMed, MEDLINE, EMBASE, Google Scholar, African Journals Online, African Index Medicus, Popline and the Cochrane Library. After the selection of eligible studies from the search output, review of full text, data extraction and data synthesis will be performed. Studies obtained from the review shall be evaluated for quality, risk of bias and heterogeneity. Appropriate statistical methods shall be used to pool prevalence estimates for matching studies globally and in subpopulations. This protocol has been reported as per the 2015 guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols.Ethics and disseminationThere is no requirement for ethical approval as the proposed study will use published data. The findings of this study will be published in a peer-reviewed journal and will be presented at conferences.Trial registration numberCRD42018109803.

PREVALENCE OF IRON-DEFICIENCY ANAEMIA IN BRAZILIAN CHILDREN UNDER FIVE YEARS OF AGE: A SYSTEMATIC REVIEW AND META-ANALYSIS

2020 ◽  
pp. 1-29
Author(s):  
Victor N.C. Silveira ◽  
Carolina A. Carvalho ◽  
Poliana C.A.F. Viola ◽  
Elma I.S. Magalhães ◽  
Luana L. Padilha ◽  
...  
Keyword(s):  
Systematic Review ◽  
Iron Deficiency ◽  
Low Income ◽  
Iron Deficiency Anaemia ◽  
Meta Analysis ◽  
Deficiency Anaemia ◽  
Children Under Five ◽  
Under Five ◽  
Pooled Prevalence ◽  
Brazilian Children

Abstract Iron-deficiency anaemia is considered an important public health problem both in wealthier countries and in those of medium and low income, especially in children under five years of age. The shortage of studies with national representativity in medium income countries, such as Brazil, prevents the knowledge of the current situation and its associated factors. We conducted a systematic review and meta-analysis to estimate the pooled prevalence of iron-deficiency anaemia in Brazilian children under five years of age and determined the factors involved in the variability of the estimates of prevalence. We collected 57 studies from the databases MEDLINE, LILACS, and Web of Science, along with the reference lists of included articles. We contacted authors for unpublished data. We did not restrict publication timespan and language. This systematic review and meta-analysis were reported according to the guidelines by PRISMA. The pooled prevalence of anaemia in children under five years of age in Brazil was 40.2% (CI95%: 36.0-44.8). The age range of the child and the period of data collection were associated with the anaemia prevalence. The pooled prevalence of anaemia was higher in children under 24 month of age (53.5% vs 30.7%; p<0.001) and in studies with data collected before 2004 (51.8% vs 32.6%; p=0.001). The efforts made by Brazilian government were successful in the reduction of anaemia in children under five years old in Brazil in the evaluated period. However, prevalence remains beyond acceptable levels for this populational group.

Intravenous Iron Sucrose versus Oral Iron in the Treatment of Pregnancy with Iron Deficiency Anaemia: A Systematic Review

2015 ◽  
Vol 80 (3) ◽  
pp. 170-178 ◽  
Author(s):  
Qingquan Shi ◽  
Wenying Leng ◽  
Romel Wazir ◽  
Jinhong Li ◽  
Qiang Yao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Sucrose ◽  
Deficiency Anaemia

scholarly journals Parenteral Versus Oral Iron for Treatment of Iron Deficiency Anaemia During Pregnancy and post-partum: A Systematic Review

2019 ◽  
Vol 69 (1) ◽  
pp. 13-24 ◽  
Author(s):  
A. G. Radhika ◽  
Aparna Kandala Sharma ◽  
Vanamail Perumal ◽  
Anju Sinha ◽  
Vasumathi Sriganesh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Post Partum ◽  
Oral Iron ◽  
Deficiency Anaemia

Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis

2018 ◽  
Vol 10 (1) ◽  
pp. 01-10 ◽  
Author(s):  
Roopa Satyanarayan Basutkar ◽  
Tenzin Tsundue ◽  
Hema Siva ◽  
Anju Rose ◽  
Sivasankaran Ponnusankar
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Deficiency Anaemia

scholarly journals Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hafid O. Al-Hassi ◽  
Oliver Ng ◽  
Rayko Evstatiev ◽  
Manel Mangalika ◽  
Natalie Worton ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Iron Metabolism ◽  
Iron Deficiency Anaemia ◽  
Iron Transport ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Loading ◽  
Deficiency Anaemia ◽  
Iron Treatment

AbstractOral iron promotes intestinal tumourigenesis in animal models. In humans, expression of iron transport proteins are altered in colorectal cancer. This study examined whether the route of iron therapy alters iron transport and tumour growth. Colorectal adenocarcinoma patients with pre-operative iron deficiency anaemia received oral ferrous sulphate (n = 15), or intravenous ferric carboxymaltose (n = 15). Paired (normal and tumour tissues) samples were compared for expression of iron loading, iron transporters, proliferation, apoptosis and Wnt signalling using immunohistochemistry and RT-PCR. Iron loading was increased in tumour and distributed to the stroma in intravenous treatment and to the epithelium in oral treatment. Protein and mRNA expression of proliferation and iron transporters were increased in tumours compared to normal tissues but there were no significant differences between the treatment groups. However, intravenous iron treatment reduced ferritin mRNA levels in tumours and replenished body iron stores. Iron distribution to non-epithelial cells in intravenous iron suggests that iron is less bioavailable to tumour cells. Therefore, intravenous iron may be a better option in the treatment of colorectal cancer patients with iron deficiency anaemia due to its efficiency in replenishing iron levels while its effect on proliferation and iron metabolism is similar to that of oral iron treatment.

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