scholarly journals Transplantation of the heart after circulatory death of the donor: time for a change in law?

2015 ◽  
Vol 203 (6) ◽  
pp. 268-270 ◽  
Author(s):  
James Tibballs ◽  
Neera Bhatia
Keyword(s):  
Transplantation Of The Heart ◽  
Circulatory Death

Uncontrolled donation after circulatory death and liver transplantation: evidence and unresolved issues

2020 ◽  
Vol 86 (2) ◽  
Author(s):  
Chiara Lazzeri ◽  
Manuela Bonizzoli ◽  
Fabio Marra ◽  
Paolo Muiesan ◽  
Davide Ghinolfi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Donation After Circulatory Death ◽  
Circulatory Death

Donation after circulatory death: possible strategies for in-situ organ preservation

2020 ◽  
Vol 86 (9) ◽  
Author(s):  
Marinella Zanierato ◽  
Daniele Dondossola ◽  
Alessandro Palleschi ◽  
Alberto Zanella
Keyword(s):  
Organ Preservation ◽  
Donation After Circulatory Death ◽  
Circulatory Death

scholarly journals Mitochondrial Reprogramming—What Is the Benefit of Hypothermic Oxygenated Perfusion in Liver Transplantation?

2021 ◽  
Vol 2 (2) ◽  
pp. 149-161
Author(s):  
Rebecca Panconesi ◽  
Mauricio Flores Carvalho ◽  
Matteo Mueller ◽  
Philipp Dutkowski ◽  
Paolo Muiesan ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Clinical Trials ◽  
Randomized Controlled Trial ◽  
Cohort Studies ◽  
Controlled Trial ◽  
Machine Perfusion ◽  
Randomized Controlled ◽  
Hypothermic Perfusion ◽  
Underlying Mechanisms ◽  
Circulatory Death

Although machine perfusion is a hot topic today, we are just at the beginning of understanding the underlying mechanisms of protection. Recently, the first randomized controlled trial reported a significant reduction of ischemic cholangiopathies after transplantation of livers donated after circulatory death, provided the grafts were treated with an endischemic hypothermic oxygenated perfusion (HOPE). This approach has been known for more than fifty years, and was initially mainly used to preserve kidneys before implantation. Today there is an increasing interest in this and other dynamic preservation technologies and various centers have tested different approaches in clinical trials and cohort studies. Based on this, there is a need for uniform perfusion settings (perfusion route and duration), and the development of general guidelines regarding the duration of cold storage in context of the overall donor risk is also required to better compare various trial results. This article will highlight how cold perfusion protects organs mechanistically, and target such technical challenges with the perfusion setting. Finally, the options for viability testing during hypothermic perfusion will be discussed.

Invalid results of quantitative HIV and HCV NAT from living, heart beating and after circulatory death donors

2021 ◽  
Author(s):  
Victoria Stadler Tasca Ribeiro ◽  
Allana Pepes ◽  
Letícia Kraft ◽  
Paula Hansen Suss ◽  
Felipe Francisco Tuon
Keyword(s):  
Heart Beating ◽  
Circulatory Death
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