scholarly journals THE RELATIONSHIP BETWEEN CIGARETTE SMOKING AND LUNG CANCER BASED ON A LARGE SCALE COHORT STUDY IN JAPAN

1988 ◽  
Vol 9 (2) ◽  
pp. 89-101
Author(s):  
Takeshi HIRAYAMA ◽  
Suminori AKIBA
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Cigarette Smoking ◽  
Large Scale ◽  
The Relationship

scholarly journals Cigarette Smoking and Risk of Lung Cancer in Korean Men: The Seoul Male Cancer Cohort Study

2007 ◽  
Vol 22 (3) ◽  
pp. 508 ◽  
Author(s):  
Jong-Myon Bae ◽  
Moo-Song Lee ◽  
Myung-Hee Shin ◽  
Dong-Hyun Kim ◽  
Zhong-Min Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Cigarette Smoking

scholarly journals Dietary Habits and Risk of Lung Cancer Death in a Large-scale Cohort Study (JACC Study) in Japan by Sex and Smoking Habit

2001 ◽  
Vol 92 (12) ◽  
pp. 1259-1269 ◽  
Author(s):  
Kotaro Ozasa ◽  
Yoshiyuki Watanabe ◽  
Yoshinori Ito ◽  
Koji Suzuki ◽  
Akiko Tamakoshi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Large Scale ◽  
Dietary Habits ◽  
Smoking Habit ◽  
Cancer Death ◽  
Lung Cancer Death

scholarly journals Increased risk of secondary lung cancer in patients with tuberculosis: A nationwide, population-based cohort study

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0250531
Author(s):  
Li-Ju Ho ◽  
Hung-Yi Yang ◽  
Chi-Hsiang Chung ◽  
Wei-Chin Chang ◽  
Sung-Sen Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Large Scale ◽  
Primary Lung Cancer ◽  
Significant Risk ◽  
Population Based ◽  
Chronic Obstructive ◽  
Primary Cancer ◽  
Increased Risk ◽  
Subsequent Risk

Background Tuberculosis (TB) presents a global threat in the world and the lung is the frequent site of metastatic focus. A previous study demonstrated that TB might increase primary lung cancer risk by two-fold for more than 20 years after the TB diagnosis. However, no large-scale study has evaluated the risk of TB and secondary lung cancer. Thus, we evaluated the risk of secondary lung cancer in patients with or without tuberculosis (TB) using a nationwide population-based dataset. Methods In a cohort study of 1,936,512 individuals, we selected 6934 patients among patients with primary cancer and TB infection, based on the International Classification of Disease (ICD-p-CM) codes 010–011 from 2000 to 2015. The control cohort comprised 13,868 randomly selected, propensity-matched patients (by age, gender, and index date) without TB exposure. Using this adjusted date, a possible association between TB and the risk of developing secondary lung cancer was estimated using a Cox proportional hazards regression model. Results During the follow-up period, secondary lung cancer was diagnosed in 761 (10.97%) patients with TB and 1263 (9.11%) patients without TB. After adjusting for covariates, the risk of secondary lung cancer was 1.67 times greater among primary cancer in the cohort with TB than in the cohort without TB. Stratification revealed that every comorbidity (including diabetes, hypertension, cirrhosis, congestive heart failure, cardiovascular accident, chronic kidney disease, chronic obstructive pulmonary disease) significantly increased the risk of secondary lung cancer when comparing the TB cohort with the non-TB cohort. Moreover, the primary cancer types (including head and neck, colorectal cancer, soft tissue sarcoma, breast, kidney, and thyroid cancer) had a more significant risk of becoming secondary lung cancer. Conclusion A significant association exists between TB and the subsequent risk for metastasis among primary cancers and comorbidities. Therefore, TB patients should be evaluated for the subsequent risk of secondary lung cancer.

scholarly journals Smoking of tobacco is the cause of human lung cancer

2019 ◽  
Vol 9 (1-s) ◽  
pp. 148-160
Author(s):  
Ilija Barukčić
Keyword(s):  
Lung Cancer ◽  
Cigarette Smoking ◽  
Causal Relationship ◽  
Null Hypothesis ◽  
Human Lung ◽  
Meta Analysis ◽  
Total Sample ◽  
Human Lung Cancer ◽  
P Value ◽  
The Relationship

Objective: The aim of this study is to re-evaluate the relationship between smoking and lung cancer. Methods: In order to clarify the relationship between cigarette smoking and lung cancer, a review and meta-analysis of appropriate studies with a total sample size of n = 48393 was conducted. The p-value was set to p < 0,05. Results: It was not possible to reject the null-hypothesis H0: without smoking no lung cancer. Furthermore, the null-hypothesis H0: No causal relationship between smoking and lung cancer was rejected. Conclusions: Compared to the results from previous studies, the results of this study confirm previously published results. According the results of this study, without smoking no lung cancer. Smoking is the cause of lung cancer. Keywords: Smoking, lung cancer, causal relationship

scholarly journals Efficacy of definite concurrent chemoradiotherapy for patients with limited-disease small-cell lung cancer: a retrospective, nationwide, population-based cohort study

2020 ◽  
Author(s):  
Seoree Kim ◽  
Ji Hyung Hong ◽  
Soo-Yoon Sung ◽  
Yeo Hyung Kim ◽  
Sang Hoon Chun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Large Scale ◽  
Concurrent Chemoradiotherapy ◽  
Single Agent ◽  
Small Cell ◽  
Small Cell Lung ◽  
Limited Disease

Abstract Background: Small-cell lung cancer (SCLC) is a highly proliferative, rapidly growing tumor with a poor prognosis, even in cases of limited disease (LD). Timely and accurate high-intensity therapy is necessary. For concurrent chemoradiotherapy (CCRT), etoposide/platinum (EP)-based regimens are recommended, although irinotecan/platinum (IP)-based regimens are also effective with radiotherapy. This large-scale, retrospective, nationwide cohort study aimed to analyze the efficacy of CCRT in patients with LD-SCLC. Methods: Population data registered between January 2008 and December 2018 was extracted from the Health Insurance Review and Assessment Service of Korea database. Survival outcomes of 4,446 LD-SCLC patients who received CCRT were analyzed. Results: Patients who received EP-CCRT (n = 4,187) showed better progression-free survival (PFS: 11.2 months) and overall survival (OS: 22.2 months) than those who received IP-CCRT (n = 259; PFS: 9.6 months, P = 0.0477; OS: 16.4 months, P <0.0001). When CCRT failed, dual-agent chemotherapy (n = 925; OS: 9.1 months) provided a better survival benefit than single-agent chemotherapy (n = 815; OS: 7.5 months). IP-based chemotherapy resulted in better OS (9.6 months) than EP-based chemotherapy (7.1 months, P = 0.017) in platinum-resistant relapsed patients; the opposite was observed for platinum-sensitive relapsed patients (OS: EP, 17.2 months; IP, 6.6 months; P <0.0001). Poisson regression analysis demonstrated that age, EP-CCRT, and hypercholesterolemia retained significant associations with OS after adjustment for all variables. Conclusion: In the Korean population, the effects of EP-CCRT on OS and PFS are significantly more favorable than those of IP-CCRT.

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