scholarly journals Large Scale Cohort Study of the Relationship Between Serum Cholesterol Concentration and Coronary Events With Low-Dose Simvastatin Therapy in Japanese Patients With Hypercholesterolemia

2002 ◽  
Vol 66 (12) ◽  
pp. 1087-1095 ◽  
Author(s):  
Masunori Matsuzaki ◽  
Toru Kita ◽  
Hiroshi Mabuchi ◽  
Yuji Matsuzawa ◽  
Noriaki Nakaya ◽  
...  
Keyword(s):  
Cohort Study ◽  
Serum Cholesterol ◽  
Large Scale ◽  
Low Dose ◽  
Japanese Patients ◽  
Cholesterol Concentration ◽  
Serum Cholesterol Concentration ◽  
Simvastatin Therapy ◽  
Coronary Events ◽  
The Relationship

scholarly journals Effect of modification of thyroid function on cholesterol 7α-hydroxylation in rat liver

1975 ◽  
Vol 148 (3) ◽  
pp. 499-503 ◽  
Author(s):  
N Takeuchi ◽  
M Ito ◽  
K Uchida ◽  
Y Yamamura
Keyword(s):  
Thyroid Function ◽  
Serum Cholesterol ◽  
Cholesterol Synthesis ◽  
Low Dose ◽  
Cholesterol Concentration ◽  
Hydroxylase Activity ◽  
Synthetic Enzymes ◽  
Glucose Administration ◽  
Serum Cholesterol Concentration ◽  
High Doses

Hepatic activities of cholesterol synthesis and cholesterol 7 alpha-hydroxylation were determined in hyper- and hypo-thyroid rats after oral administration of glucose or cholesterol. Increases in activities of both cholesterol synthesis and cholesterol 7 alpha-hydroxylation induced by glucose administration were enhanced by pretreatment with thyroid powder but suppressed by pretreatment with thiouracil. The enhancement of 7 alpha-hydroxylation was produced by a relatively small amount of thyroid powder, but high doses were required to increase cholesterol synthesis. On the other hand, the suppression of 7 alpha-hydroxylation was brought about by a low dose of thiouracil, but high doses were required to decrease cholesterol synthesis. Although cholesterol synthesis increased similarly in both hypo- and hyper-thyroid rats after glucose administration, hydroxylase activity in hypothyroid rats began to increase more slowly and was always lower than that in hyperthyroid rats. Thus it is concluded that cholesterol 7 alpha-hydroxylase activity is more sensitive to thyroid function than are activities of cholesterol-synthetic enzymes. When exogenous cholesterol was given, hypothyroid rats showed a larger increase in serum cholesterol concentration than hyperthyroid rats, and there was an inverse relationship between serum cholesterol concentrations and hepatic cholesterol 7 alpha-hydroxylase activities.

Cholesterol and psyche

1995 ◽  
Vol 7 (4) ◽  
pp. 122-126 ◽  
Author(s):  
N. Duits ◽  
W. Van Tilburg
Keyword(s):  
Serum Cholesterol ◽  
Psychological Functioning ◽  
Impulse Control ◽  
Cholesterol Concentration ◽  
Serotonin Metabolism ◽  
Epidemiologic Research ◽  
Serum Cholesterol Concentration ◽  
Meta Analyses ◽  
The Relationship ◽  
Low Serum

SummaryThis paper reviews the relationship between cholesterol and psychological functioning. Possibly a relationship exists between the lowering of cholesterol, low serum cholesterol concentration and mood and/or impulse control disorders. This might be associated with a disregulated cerebral serotonin metabolism. These hypotheses are based on (meta-analyses of) epidemiologic research investigating the lowering of cholesterol. One of the findings was an increased mortality due to suicide, homicide and accidents. Much is still unknown about the matters mentioned above. However, recommendations for research and clinical psychiatric practice are formulated.

scholarly journals Relationship Between Coronary Events and Serum Cholesterol During 10 Years of Low-Dose Simvastatin Therapy

2008 ◽  
Vol 72 (8) ◽  
pp. 1218-1224 ◽  
Author(s):  
Hiroshige Itakura ◽  
Toru Kita ◽  
Hiroshi Mabuchi ◽  
Masunori Matsuzaki ◽  
Yuji Matsuzawa ◽  
...  
Keyword(s):  
Serum Cholesterol ◽  
Low Dose ◽  
Simvastatin Therapy ◽  
Coronary Events

scholarly journals Obesity as a Risk Factor for Coronary Events in Japanese Patients with Hypercholesterolemia on Low-Dose Simvastatin Therapy

2010 ◽  
Vol 17 (3) ◽  
pp. 270-277 ◽  
Author(s):  
Yasushi Saito ◽  
Toru Kita ◽  
Hiroshi Mabuchi ◽  
Masunori Matsuzaki ◽  
Yuji Matsuzawa ◽  
...  
Keyword(s):  
Risk Factor ◽  
Low Dose ◽  
Japanese Patients ◽  
Simvastatin Therapy ◽  
Coronary Events
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