scholarly journals STATISTICAL EVALUATION OF CIRCADIAN RHYTHM IN BLOOD PRESSURE FLUCTUATIONS

1986 ◽  
Vol 7 (0) ◽  
pp. 39-48
Author(s):  
Yasunori URAGARI ◽  
Masashi GOTO ◽  
Takeaki NAGAI
Keyword(s):  
Blood Pressure ◽  
Circadian Rhythm ◽  
Statistical Evaluation ◽  
Pressure Fluctuations

scholarly journals BAYESIAN EVALUATION OF CIRCADIAN RHYTHM IN BLOOD PRESSURE FLUCTUATIONS

1987 ◽  
Vol 8 (2) ◽  
pp. 2_111-120
Author(s):  
Yasunori URAGARI ◽  
Masashi GOTO ◽  
Takeaki NAGAI
Keyword(s):  
Blood Pressure ◽  
Circadian Rhythm ◽  
Pressure Fluctuations

scholarly journals Antihypertensives’ Rock around the Clock

J ◽  
2021 ◽  
Vol 4 (1) ◽  
pp. 62-82
Author(s):  
Ognjenka Rahić ◽  
Amina Tucak ◽  
Merima Sirbubalo ◽  
Lamija Hindija ◽  
Jasmina Hadžiabdić
Keyword(s):  
Blood Pressure ◽  
Circadian Rhythm ◽  
Drug Release ◽  
Strong Evidence ◽  
Clinical Evidence ◽  
Pressure Fluctuations ◽  
The Body ◽  
Biological Processes ◽  
Approval Process ◽  
Incontrovertible Evidence

Although homeostasis is a commonly accepted concept, there is incontrovertible evidence that biological processes and functions are variable and that variability occurs in cycles. In order to explain and understand dysregulation, which has not been embraced by homeostatic principles, the allostatic model has emerged as the first serious challenge to homeostasis, going beyond its homeostatic roots. Circadian rhythm is the predominant variation in the body, and it is a pattern according to which many physiological and pathological events occur. As there is strong experimental and clinical evidence that blood pressure fluctuations undergo circadian rhythm, there is equally strong evidence that targeted time therapy for hypertension provides a better outcome of the disease. The research has gone even further throughout the development and approval process for the use of pulsatile drug release systems, which can be considered as an option for an even more convenient dosage regimen of the medicines needed.

scholarly journals Circadian Blood Pressure Rhythm in Cardiovascular and Renal Health and Disease

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 868
Author(s):  
Jiayang Zhang ◽  
Ruoyu Sun ◽  
Tingting Jiang ◽  
Guangrui Yang ◽  
Lihong Chen
Keyword(s):  
Blood Pressure ◽  
Circadian Rhythm ◽  
Molecular Mechanisms ◽  
Current Understanding ◽  
Renal Outcomes ◽  
Circadian Blood Pressure ◽  
Health And Disease ◽  
The Relationship

Blood pressure (BP) follows a circadian rhythm, it increases on waking in the morning and decreases during sleeping at night. Disruption of the circadian BP rhythm has been reported to be associated with worsened cardiovascular and renal outcomes, however the underlying molecular mechanisms are still not clear. In this review, we briefly summarized the current understanding of the circadian BP regulation and provided therapeutic overview of the relationship between circadian BP rhythm and cardiovascular and renal health and disease.

Disturbance of circadian rhythm of blood pressure and pulse rate in children with cerebral palsy. Treatment with vitamin B12

1993 ◽  
Vol 45 (3) ◽  
pp. 259-260
Author(s):  
Teruo Yamauchi ◽  
Mikio Osawa ◽  
Tsunehiko Suzuki ◽  
Yoko Miura ◽  
Yuko Sugishita ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cerebral Palsy ◽  
Circadian Rhythm ◽  
Vitamin B12 ◽  
Pulse Rate ◽  
Children With Cerebral Palsy

Cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension at rest and during orthostatic stress: Role of the peripheral chemoreflex

2021 ◽  
Author(s):  
Marcelle Paula-Ribeiro ◽  
Indyanara C. Ribeiro ◽  
Liliane C. Aranda ◽  
Talita M. Silva ◽  
Camila M. Costa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Early Stage ◽  
Pressure Fluctuations ◽  
Sit To Stand ◽  
Peak Aerobic Capacity ◽  
Pulmonary Arterial ◽  
Peripheral Chemoreflex

The baroreflex integrity in early-stage pulmonary arterial hypertension (PAH) remains uninvestigated. A potential baroreflex impairment could be functionally relevant and possibly mediated by enhanced peripheral chemoreflex activity. Thus, we investigated 1) the cardiac baroreflex in non-hypoxemic PAH; 2) the association between baroreflex indexes and peak aerobic capacity (i.e., V̇O2peak); and 3) the peripheral chemoreflex contribution to the cardiac baroreflex. Nineteen patients and 13 age- and sex-matched healthy adults (HA) randomly inhaled either 100% O2 (peripheral chemoreceptors inhibition) or 21% O2 (control session), while at rest and during a repeated sit-to-stand maneuver. Beat-by-beat analysis of R-R intervals and systolic blood pressure provided indexes of cardiac baroreflex sensitivity (cBRS) and effectiveness (cBEI). The PAH group had lower cBEIALL at rest (mean ± SD: PAH = 0.5 ± 0.2 vs HA = 0.7 ± 0.1 a.u., P = 0.02) and lower cBRSALL (PAH = 6.8 ± 7.0 vs HA = 9.7 ± 5.0 ms mmHg-1, P < 0.01) and cBEIALL (PAH = 0.4 ± 0.2 vs HA= 0.6 ± 0.1 a.u., P < 0.01) during the sit-to-stand maneuver versus the HA group. The cBEI during the sit-to-stand maneuver was independently correlated to V̇O2peak (partial r = 0.45, P < 0.01). Hyperoxia increased cBRS and cBEI similarly in both groups at rest and during the sit-to-stand maneuver. Therefore, cardiac baroreflex dysfunction was observed under spontaneous and, most notably, provoked blood pressure fluctuations in non-hypoxemic PAH, was not influenced by the peripheral chemoreflex, and was associated with lower V̇O2peak suggesting it could be functionally relevant.

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