scholarly journals Sleep Duration and White Matter Quality in Middle-Aged Adults

SLEEP ◽  
2016 ◽  
Vol 39 (9) ◽  
pp. 1743-1747 ◽  
Author(s):  
Kristine Yaffe ◽  
Ilya Nasrallah ◽  
Tina D. Hoang ◽  
Diane S. Lauderdale ◽  
Kristen L. Knutson ◽  
...  
Keyword(s):  
White Matter ◽  
Sleep Duration ◽  
Middle Aged ◽  
Middle Aged Adults

Does Sleep Duration Differ By Diabetes Status in Middle-Aged Adults?

2018 ◽  
Vol 03 (03) ◽  
Author(s):  
Graham EK ◽  
Alden BL ◽  
Kaur H ◽  
Wingo AR ◽  
Hartos JL
Keyword(s):  
Sleep Duration ◽  
Middle Aged ◽  
Diabetes Status ◽  
Middle Aged Adults

Visceral Adiposity Predicts Subclinical White Matter Hyperintensities in Middle-Aged Adults

2016 ◽  
Vol 48 ◽  
pp. 426
Author(s):  
Evan P. Pasha ◽  
Alex C. Birdsill ◽  
Paige Parker ◽  
Ahmed Elmenshaway ◽  
Hirofumi Tanaka ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Visceral Adiposity ◽  
Middle Aged ◽  
Middle Aged Adults

The impact of the sleep duration on NAFLD score in Korean middle-aged adults: a community-based cohort study

2019 ◽  
Vol 57 ◽  
pp. 144-150 ◽  
Author(s):  
Ji-Hye Kim ◽  
Dong-Hyuk Jung ◽  
Yu-Jin Kwon ◽  
Jung-Il Lee ◽  
Jae-Yong Shim
Keyword(s):  
Cohort Study ◽  
Sleep Duration ◽  
Middle Aged ◽  
Community Based ◽  
Middle Aged Adults ◽  
The Impact

Abstract 28: Regular Aerobic Exercise Counteracts Endothelial Vasomotor Dysfunction Associated With Insufficient Sleep

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Kelly A Stockelman ◽  
Anthony R Bain ◽  
Caitlin A Dow ◽  
Jared J Greiner ◽  
Brian L Stauffer ◽  
...  
Keyword(s):  
Exercise Training ◽  
Aerobic Exercise ◽  
Sleep Duration ◽  
Middle Aged ◽  
Short Sleep Duration ◽  
Insufficient Sleep ◽  
Short Sleep ◽  
Vasomotor Regulation ◽  
Normal Sleep ◽  
Middle Aged Adults

Insufficient sleep, defined as chronic short sleep duration (<7 h/night), is an independent risk factor for cardiovascular disease (CVD). We have previously demonstrated that insufficient sleep is associated with reduced endothelium-dependent vasodilation and enhanced endothelin (ET)-1-mediated vasoconstrictor tone. Impaired endothelial vasomotor regulation is thought to contribute mechanistically to the increased risk of atherosclerotic vascular disease incurred with chronic insufficient sleep. Regular aerobic exercise is an effective lifestyle strategy for improving endothelial function and, in turn reducing cardiovascular risk. It is currently unknown if regular aerobic exercise can counteract the negative impact of insufficient sleep on endothelial vasomotor regulation. We tested the hypotheses that regular aerobic exercise would: 1) improve endothelial vasodilation; and 2) decrease ET-1-mediated vasoconstrictor tone in middle-aged adults who chronically sleep less than 7 h/night. We studied 36 healthy, middle-aged adults: 16 with normal sleep duration (10M/6F; age: 57±2 yr; sleep duration: 7.4±0.1 h/night) and 20 with short sleep duration (11M/9F; 56±1 yr; sleep duration: 6.2±0.1 h/night). The 20 short sleepers completed a 3-month aerobic exercise training intervention. Forearm blood flow (FBF; plethysmography) was determined in response to intra-arterial doses of acetylcholine (ACh), sodium nitroprusside (SNP), BQ-123 (ET A receptor antagonist) and ACh + BQ-123 in both groups and after the exercise intervention in the short sleepers. As expected, forearm vasodilator responses to ACh were lower (20%; P<0.05) in the short (from 4.2±0.2 to 10.5±0.6 mL/100 mL tissue/min) vs normal (4.2±0.2 to 12.7±0.6 mL/100 mL tissue/min) sleepers. FBF responses to SNP were comparable between the groups. In response to BQ-123, short sleep group had a greater increase in resting FBF than normal sleep group (~25% vs ~8%; P< 0.05). ACh+BQ-123 resulted in an ~25% increase in the ACh-vasodilation in the short sleep group only. After exercise training, although nightly sleep duration was not affected (6.4±0.1 h/night), ACh-mediated vasodilation was ~20% higher (P<0.05), ET-1-mediated vasoconstriction was ~90% lower (P<0.05) and vasodilator response to ACh was not significantly increased with ET A receptor blockade. These results indicate that regular aerobic exercise can reverse the negative influence of insufficient sleep on endothelial vasomotor function, independent of changes in nightly sleep duration.

scholarly journals White matter hyperintensities in middle-aged adults with childhood-onset type 1 diabetes

Neurology ◽  
2015 ◽  
Vol 84 (20) ◽  
pp. 2062-2069 ◽  
Author(s):  
K. A. Nunley ◽  
C. M. Ryan ◽  
T. J. Orchard ◽  
H. J. Aizenstein ◽  
J. R. Jennings ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Middle Aged ◽  
Childhood Onset ◽  
Onset Type ◽  
Middle Aged Adults

scholarly journals The Haptoglobin 1 Allele Correlates With White Matter Hyperintensities in Middle-Aged Adults With Type 1 Diabetes

Diabetes ◽  
2014 ◽  
Vol 64 (2) ◽  
pp. 654-659 ◽  
Author(s):  
Tina Costacou ◽  
Caterina Rosano ◽  
Howard Aizenstein ◽  
Joseph M. Mettenburg ◽  
Karen Nunley ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Middle Aged ◽  
Middle Aged Adults
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