scholarly journals The Haptoglobin 1 Allele Correlates With White Matter Hyperintensities in Middle-Aged Adults With Type 1 Diabetes

Diabetes ◽  
2014 ◽  
Vol 64 (2) ◽  
pp. 654-659 ◽  
Author(s):  
Tina Costacou ◽  
Caterina Rosano ◽  
Howard Aizenstein ◽  
Joseph M. Mettenburg ◽  
Karen Nunley ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Middle Aged ◽  
Middle Aged Adults

scholarly journals White matter hyperintensities in middle-aged adults with childhood-onset type 1 diabetes

Neurology ◽  
2015 ◽  
Vol 84 (20) ◽  
pp. 2062-2069 ◽  
Author(s):  
K. A. Nunley ◽  
C. M. Ryan ◽  
T. J. Orchard ◽  
H. J. Aizenstein ◽  
J. R. Jennings ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Middle Aged ◽  
Childhood Onset ◽  
Onset Type ◽  
Middle Aged Adults

scholarly journals Long-term changes in retinal vascular diameter and cognitive impairment in type 1 diabetes

2018 ◽  
Vol 15 (3) ◽  
pp. 223-232 ◽  
Author(s):  
Karen A Nunley ◽  
Andrea L Metti ◽  
Ronald Klein ◽  
Barbara E Klein ◽  
Judith A Saxton ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cognitive Impairment ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Proliferative Retinopathy ◽  
Retinal Arteriolar ◽  
Central Retinal Arteriolar Equivalent ◽  
Central Retinal Venular Equivalent

Objective: To assess associations between cognitive impairment and longitudinal changes in retinal microvasculature, over 18 years, in adults with type 1 diabetes. Research design and methods: Participants of the Pittsburgh Epidemiology of Diabetes Complications Study received ≥3 fundus photographs between baseline (1986–1988) and time of cognitive assessment (2010–2015: N = 119; 52% male; mean age and type 1 diabetes duration 43 and 34 years, respectively). Central retinal arteriolar equivalent and central retinal venular equivalent were estimated via computer-based methods; overall magnitude and speed of narrowing were quantified as cumulative average and slope, respectively. Median regression models estimated associations of central retinal arteriolar equivalent and central retinal venular equivalent measures with cognitive impairment status, adjusted for type 1 diabetes duration. Interactions with HbA1c, proliferative retinopathy and white matter hyperintensities were assessed. Results: Compared with participants without cognitive impairment, those with clinically relevant cognitive impairment experienced 1.8% greater and 31.1% faster central retinal arteriolar equivalent narrowing during prior years (t = −2.93, p = 0.004 and t = −3.97, p < 0.0001, respectively). Interactions with HbA1c, proliferative retinopathy and white matter hyperintensities were not significant. No associations were found between central retinal arteriolar equivalent at baseline, at time of cognitive testing, or any central retinal venular equivalent measures, and cognitive impairment. Conclusion: Long-term arterial retinal changes could indicate type 1 diabetes–related cognitive impairment. Studies examining longitudinal central retinal arteriolar equivalent changes as early biomarkers of cognitive impairment risk are warranted.

Visceral Adiposity Predicts Subclinical White Matter Hyperintensities in Middle-Aged Adults

2016 ◽  
Vol 48 ◽  
pp. 426
Author(s):  
Evan P. Pasha ◽  
Alex C. Birdsill ◽  
Paige Parker ◽  
Ahmed Elmenshaway ◽  
Hirofumi Tanaka ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Visceral Adiposity ◽  
Middle Aged ◽  
Middle Aged Adults

scholarly journals Statin use and cognitive function in middle-aged adults with type 1 diabetes

2017 ◽  
Vol 8 (6) ◽  
pp. 286 ◽  
Author(s):  
Karen A Nunley ◽  
Trevor J Orchard ◽  
Christopher M Ryan ◽  
Rachel Miller ◽  
Tina Costacou ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cognitive Function ◽  
Middle Aged ◽  
Middle Aged Adults ◽  
Statin Use

scholarly journals Response to Comment on Nunley et al. Clinically Relevant Cognitive Impairment in Middle-Aged Adults With Childhood-Onset Type 1 Diabetes. Diabetes Care 2015;38:1768–1776

Diabetes Care ◽  
2016 ◽  
Vol 39 (2) ◽  
pp. e25-e25 ◽  
Author(s):  
Karen A. Nunley ◽  
Christopher M. Ryan ◽  
Judith A. Saxton ◽  
Tina Costacou ◽  
Trevor J. Orchard ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cognitive Impairment ◽  
Diabetes Care ◽  
Middle Aged ◽  
Childhood Onset ◽  
Onset Type ◽  
Middle Aged Adults

scholarly journals Clinically Relevant Cognitive Impairment in Middle-Aged Adults With Childhood-Onset Type 1 Diabetes

Diabetes Care ◽  
2015 ◽  
Vol 38 (9) ◽  
pp. 1768-1776 ◽  
Author(s):  
Karen A. Nunley ◽  
Caterina Rosano ◽  
Christopher M. Ryan ◽  
J. Richard Jennings ◽  
Howard J. Aizenstein ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cognitive Impairment ◽  
Middle Aged ◽  
Childhood Onset ◽  
Onset Type ◽  
Middle Aged Adults

1408-P: Gait Speed and Handgrip Strength in Middle-Aged Adults with Type 1 Diabetes: Comparison with Normative Values and Correlates

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1408-P
Author(s):  
TINA COSTACOU ◽  
ELSA S. STROTMEYER ◽  
TREVOR J. ORCHARD
Keyword(s):  
Type 1 Diabetes ◽  
Gait Speed ◽  
Handgrip Strength ◽  
Normative Values ◽  
Middle Aged ◽  
Middle Aged Adults
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