scholarly journals Effects of Stressor Predictability on Escape Learning and Sleep in Mice

SLEEP ◽  
2013 ◽  
Vol 36 (3) ◽  
pp. 421-430 ◽  
Author(s):  
Mayumi Machida ◽  
Linghui Yang ◽  
Laurie L. Wellman ◽  
Larry D. Sanford
Keyword(s):  
2015 ◽  
Vol 9s1 ◽  
pp. JEN.S32735
Author(s):  
Darryl J. Mayeaux ◽  
Sarah M. Tandle ◽  
Sean M. Cilano ◽  
Matthew J. Fitzharris

In animal models of depression, depression is defined as performance on a learning task. That task is typically escaping a mild electric shock in a shuttle cage by moving from one side of the cage to the other. Ovarian hormones influence learning in other kinds of tasks, and these hormones are associated with depressive symptoms in humans. The role of these hormones in shuttle-cage escape learning, however, is less clear. This study manipulated estradiol and progesterone in ovariectomized female rats to examine their performance in shuttle-cage escape learning without intentionally inducing a depressive-like state. Progesterone, not estradiol, within four hours of testing affected latencies to escape. The improvement produced by progesterone was in the decision to act, not in the speed of learning or speed of escaping. This parallels depression in humans in that depressed people are slower in volition, in their decisions to take action.


1987 ◽  
Vol 26 (2-3) ◽  
pp. 219-220
Author(s):  
G. Goodall ◽  
J.-M. Guastavino

1972 ◽  
Vol 5 (3) ◽  
pp. 259-268 ◽  
Author(s):  
Z. Michael Nagy ◽  
James R. Misanin ◽  
Peter L. Olsen
Keyword(s):  
C3h Mice ◽  

1994 ◽  
Vol 108 (1) ◽  
pp. 94-99 ◽  
Author(s):  
David J. Hinkle ◽  
David C. Wood

1977 ◽  
Vol 91 (2) ◽  
pp. 260-269 ◽  
Author(s):  
Frank C. Leeming ◽  
Gregory L. Little

1974 ◽  
Vol 4 (2) ◽  
pp. 111-124 ◽  
Author(s):  
Michael F. W. Festing
Keyword(s):  

1966 ◽  
Vol 19 (3_suppl) ◽  
pp. 1127-1131
Author(s):  
Dennis J. Delprato ◽  
Richard W. Thompson

Two experiments investigated the effect of shock intensity on escape learning in a straight alley (Exp. I) or avoidance learning in a one-way shuttle box (Exp. II) in operated control (OC) rats or rats under bilateral spreading depression (BSD). Results of Exp. I using 0.6-, 1.2-, and 2.4-ma. shock indicated no interaction of shock level with cortical treatment and that BSD Ss were inferior to OC Ss. A low level of shock resulted in poorer performance than intense shock. Results of Exp. II using 0.4- and 2.0-ma. shock indicated a shock by cortical treatment interaction. 0.4-ma. BSD Ss were inferior in latency to 2.0-ma. BSD Ss and 0.4-ma. OC Ss.


1984 ◽  
Vol 14 (3) ◽  
pp. 221-233 ◽  
Author(s):  
Johannes Horst Schr�der ◽  
Malte Sund

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