Inheritance of water-escape performance and water-escape learning in mice

1984 ◽  
Vol 14 (3) ◽  
pp. 221-233 ◽  
Author(s):  
Johannes Horst Schr�der ◽  
Malte Sund
1986 ◽  
Vol 58 (1) ◽  
pp. 3-9 ◽  
Author(s):  
Bruce A. Mattingly ◽  
James E. Gotsick ◽  
E. Brooks Applegate

The involvement of reduced serotonin in deficient leverpress, shock-escape performance of rats with septal lesions was assessed in two studies. In Exp. 1, rats were treated with either para-chlorophenylalanine (PCPA) or saline and then tested in a leverpress, shock-escape task. In Exp. 2, rats with septal lesions and sham-operated control rats were treated daily with either 5-hydroxytryptophan (5HTP) or saline and tested on the same shock-escape task. Primary findings were as follows: (a) rats treated with PCPA learned to escape shock as quickly as saline control rats; (b) the shock-escape performance of rats with septal lesions was significantly inferior to that of control rats; and (c) the administration of 5HTP did not significantly improve the performance of either lesioned or control rats. These results suggest that the reduction of brain serotonin induced by septal lesions is not involved in the deficient shock-escape performance of septal-lesioned rats.


2020 ◽  
Vol 10 (10) ◽  
pp. 4251-4260
Author(s):  
Gaoyang Yu ◽  
Jinxin Guo ◽  
Wenqian Xie ◽  
Jun Wang ◽  
Yichen Wu ◽  
...  

2015 ◽  
Vol 9s1 ◽  
pp. JEN.S32735
Author(s):  
Darryl J. Mayeaux ◽  
Sarah M. Tandle ◽  
Sean M. Cilano ◽  
Matthew J. Fitzharris

In animal models of depression, depression is defined as performance on a learning task. That task is typically escaping a mild electric shock in a shuttle cage by moving from one side of the cage to the other. Ovarian hormones influence learning in other kinds of tasks, and these hormones are associated with depressive symptoms in humans. The role of these hormones in shuttle-cage escape learning, however, is less clear. This study manipulated estradiol and progesterone in ovariectomized female rats to examine their performance in shuttle-cage escape learning without intentionally inducing a depressive-like state. Progesterone, not estradiol, within four hours of testing affected latencies to escape. The improvement produced by progesterone was in the decision to act, not in the speed of learning or speed of escaping. This parallels depression in humans in that depressed people are slower in volition, in their decisions to take action.


1984 ◽  
Vol 15 (3) ◽  
pp. 279-286 ◽  
Author(s):  
Joseph R Volpicelli ◽  
Ronald R Ulm ◽  
Aidan Altenor

2017 ◽  
Vol 124 ◽  
pp. 153-159 ◽  
Author(s):  
J. Swaegers ◽  
F. Strobbe ◽  
M.A. McPeek ◽  
R. Stoks

1987 ◽  
Vol 26 (2-3) ◽  
pp. 219-220
Author(s):  
G. Goodall ◽  
J.-M. Guastavino

1972 ◽  
Vol 5 (3) ◽  
pp. 259-268 ◽  
Author(s):  
Z. Michael Nagy ◽  
James R. Misanin ◽  
Peter L. Olsen
Keyword(s):  
C3h Mice ◽  

Polar Biology ◽  
2002 ◽  
Vol 25 (12) ◽  
pp. 914-920 ◽  
Author(s):  
Daniel A. Fernández ◽  
J. Calvo ◽  
J. Wakeling ◽  
F. Vanella ◽  
I. Johnston

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