Rise in nocturnal respiratory rate during CPAP may be an early sign of COVID-19 in patients with obstructive sleep apnea

Современные эпидемиологические исследования указывают на связь синдрома обструктивного апноэ сна с сердечно-сосудистыми заболеваниями, такими как артериальная гипертензия, ишемическая болезнь сердца, инфаркт миокарда, инсульт и нарушения ритма. Широкая распространенность в популяции обструктивных нарушений дыхания во время сна и отсутствие реальной возможности провести углубленное обследование всем потенциально нуждающимся в этом больным обусловливают необходимость разработки новых принципов диагностики. В данной статье рассматривается метод магнитной плетизмографии в качестве неинвазивного способа диагностики синдрома обструктивного апноэ сна. В исследовании решалась задача создания удобного и относительно недорогого устройства регистрации нарушений дыхания во сне. Авторами разработан и изготовлен макет биотехнической системы магнитоплетизмографии, разработано программное обеспечение приема и визуализации данных, предложен алгоритм автоматической регистрации частоты дыхательных движений, а также осуществлена апробация изделия. По результатам исследований была доказана работоспособность изделия, а именно возможность регистрации дыхательной волны с грудной и брюшной поверхности, способность обнаружения эпизодов апноэ, возможность выделения частоты дыхания и частоты сердечных сокращений, возможность проведения ночного мониторинга сна, а также доказана работоспособность алгоритма автоматической регистрации частоты дыхания. Сделан вывод о том, чтобиотехническая система может быть использована для скрининга пациентов с синдромом обструктивного апноэ сна и нуждается в дальнейшей проработке Current epidemiological studies indicate a link between obstructive sleep apnea syndrome and cardiovascular diseases such as arterial hypertension, coronary heart disease, myocardial infarction, stroke and rhythm disturbances. The widespread prevalence of obstructive breathing disorders during sleep in the population and the lack of a real opportunity to conduct an in-depth examination of all patients who potentially need this necessitate the development of new diagnostic principles.This article examines the method of magnetic plethysmography as a non-invasive method for diagnosing obstructive sleep apnea syndrome. The study solved the problem of creating a convenient and relatively inexpensive device for recording breathing disorders during sleep.The authors have developed and manufactured a mock-up of the biotechnical magnetic plethysmography system, developed software for receiving and visualizing data, proposed an algorithm for automatic registration of the frequency of respiratory movements, and also tested the product. According to the results of the research, the performance of the product was proved, namely, the ability to register a respiratory wave from the chest and abdominal surfaces, the ability to detect episodes of apnea, the ability to isolate the respiratory rate and heart rate, the ability to conduct night sleep monitoring, and the performance of the algorithm for automatic registration of the respiratory rate was proved. It was concluded that biotechnical magnetic plethysmography system can be used for screening patients with obstructive sleep apnea syndrome and needs further elaboration

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Erectile Dysfunction in Men with Obstructive Sleep Apnea: An Early Sign of Nerve Involvement

SLEEP ◽

10.1093/sleep/23.6.1e ◽

2000 ◽

Vol 23 (6) ◽

pp. 1-7 ◽

Cited By ~ 64

Author(s):

Francesco Fanfulla ◽

Silvia Malaguti ◽

Tiziana Montagna ◽

Silvana Salvini ◽

Claudio Bruschi ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Erectile Dysfunction ◽

Sleep Apnea ◽

Early Sign ◽

Nerve Involvement ◽

Obstructive Sleep

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A Novel Sleep Respiratory Rate Detection Method for Obstructive Sleep Apnea Based on Characteristic Moment Waveform

Journal of Healthcare Engineering ◽

10.1155/2018/1902176 ◽

2018 ◽

Vol 2018 ◽

pp. 1-10 ◽

Cited By ~ 11

Author(s):

Yu Fang ◽

Zhongwei Jiang ◽

Haibin Wang

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Respiratory Rate ◽

Detection Method ◽

Extreme Points ◽

Sound Signal ◽

Time Duration ◽

Scale Parameters ◽

Manual Counting ◽

Obstructive Sleep

Obstructive sleep apnea (OSA) affecting human’s health is a kind of major breathing-related sleep disorders and sometimes leads to nocturnal death. Respiratory rate (RR) of a sleep breathing sound signal is an important human vital sign for OSA monitoring during whole-night sleeping. A novel sleep respiratory rate detection with high computational speed based on characteristic moment waveform (CMW) method is proposed in this paper. A portable and wearable sound device is used to acquire the breathing sound signal. And the amplitude contrast decreasing has been done first. Then, the CMW is extracted with suitable time scale parameters, and the sleep RR value is calculated by the extreme points of CMW. Experiments of one OSA case and five healthy cases are tested to validate the efficiency of the proposed sleep RR detection method. According to manual counting, sleep RR can be detected accurately by the proposed method. In addition, the apnea sections can be detected by the sleep RR values with a given threshold, and the time duration of the segmentation of the breath can be calculated for detailed evaluation of the state of OSA. The proposed method is meaningful for continued research on the sleep breathing sound signal.

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Opioid Sensitivity in Children with and without Obstructive Sleep Apnea

Anesthesiology ◽

10.1097/aln.0000000000002664 ◽

2019 ◽

Vol 130 (6) ◽

pp. 936-945 ◽

Cited By ~ 3

Author(s):

Michael C. Montana ◽

Lindsay Juriga ◽

Anshuman Sharma ◽

Evan D. Kharasch

Keyword(s):

Carbon Dioxide ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Respiratory Rate ◽

Opioid Use ◽

Fixed Rate ◽

Opioid Agonist ◽

Perioperative Analgesia ◽

Obstructive Sleep ◽

Opioid Sensitivity

Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Opioids are a mainstay of perioperative analgesia. Opioid use in children with obstructive sleep apnea is challenging because of assumptions for increased opioid sensitivity and assumed risk for opioid-induced respiratory depression compared to children without obstructive sleep apnea. These assumptions have not been rigorously tested. This investigation tested the hypothesis that children with obstructive sleep apnea have an increased pharmacodynamic sensitivity to the miotic and respiratory depressant effects of the prototypic μ-opioid agonist remifentanil. Methods Children (8 to 14 yr) with or without obstructive sleep apnea were administered a 15-min, fixed-rate remifentanil infusion (0.05, 0.1, or 0.15 μg · kg-1 · min-1). Each dose group had five patients with and five without obstructive sleep apnea. Plasma remifentanil concentrations were measured by tandem liquid chromatography mass spectrometry. Remifentanil effects were measured via miosis, respiratory rate, and end-expired carbon dioxide. Remifentanil pharmacodynamics (miosis vs. plasma concentration) were compared in children with or without obstructive sleep apnea. Results Remifentanil administration resulted in miosis in both non-obstructive sleep apnea and obstructive sleep apnea patients. No differences in the relationship between remifentanil concentration and miosis were seen between the two groups at any of the doses administered. The administered dose of remifentanil did not affect respiratory rate or end-expired carbon dioxide in either group. Conclusions No differences in the remifentanil concentration–miosis relation were seen in children with or without obstructive sleep apnea. The dose and duration of remifentanil administered did not alter ventilatory parameters in either group.

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Treating Velopharyngeal Inadequacy Using Bilateral Buccal Flap Revision Palatoplasty

Perspectives of the ASHA Special Interest Groups ◽

10.1044/2019_pers-sig5-2019-0005 ◽

2019 ◽

Vol 4 (5) ◽

pp. 878-892

Author(s):

Joseph A. Napoli ◽

Linda D. Vallino

Keyword(s):

Systematic Review ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

A Priori ◽

Sufficient Evidence ◽

Obstructive Sleep ◽

Before And After ◽

Buccal Flap

Purpose The 2 most commonly used operations to treat velopharyngeal inadequacy (VPI) are superiorly based pharyngeal flap and sphincter pharyngoplasty, both of which may result in hyponasal speech and airway obstruction. The purpose of this article is to (a) describe the bilateral buccal flap revision palatoplasty (BBFRP) as an alternative technique to manage VPI while minimizing these risks and (b) conduct a systematic review of the evidence of BBFRP on speech and other clinical outcomes. A report comparing the speech of a child with hypernasality before and after BBFRP is presented. Method A review of databases was conducted for studies of buccal flaps to treat VPI. Using the principles of a systematic review, the articles were read, and data were abstracted for study characteristics that were developed a priori. With respect to the case report, speech and instrumental data from a child with repaired cleft lip and palate and hypernasal speech were collected and analyzed before and after surgery. Results Eight articles were included in the analysis. The results were positive, and the evidence is in favor of BBFRP in improving velopharyngeal function, while minimizing the risk of hyponasal speech and obstructive sleep apnea. Before surgery, the child's speech was characterized by moderate hypernasality, and after surgery, it was judged to be within normal limits. Conclusion Based on clinical experience and results from the systematic review, there is sufficient evidence that the buccal flap is effective in improving resonance and minimizing obstructive sleep apnea. We recommend BBFRP as another approach in selected patients to manage VPI. Supplemental Material https://doi.org/10.23641/asha.9919352

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