scholarly journals Enhancement of the Antioxidant and Anti-inflammatory Activity of Hizikia fusiforme Water Extract by Lactic Acid Bacteria Fermentation

2011 ◽  
Vol 44 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Ho-Su Song ◽  
Sung-Hwan Eom ◽  
Young-Mi Kang ◽  
Jong-Duck Choi ◽  
Young-Mog Kim
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Water Extract ◽  
Inflammatory Activity ◽  
Hizikia Fusiforme ◽  
Anti Inflammatory

scholarly journals Scientific Evaluation of anti-inflammatory potential of Macrotyloma uniflorum seeds extracts

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1883-1888
Author(s):  
Anandarajagopal K ◽  
Abdullah Khan ◽  
Sugalia S ◽  
Bama Menon ◽  
Tan Ching Siang ◽  
...  
Keyword(s):  
Antioxidant Properties ◽  
Water Extract ◽  
Ethanol Extract ◽  
Inflammatory Activity ◽  
Leguminous Plant ◽  
Paw Edema ◽  
Reference Drug ◽  
Macrotyloma Uniflorum ◽  
Phenolic Constituents ◽  
Anti Inflammatory

Phytochemicals possessing the antioxidant properties naturally present in food attract a greater interest to healthcare researchers due to their desirable health effects on human health as they can be explored for protection against oxidative deterioration. Macrtotyloma uniflorum is a leguminous plant belonging to the family Fabaceae and commonly known as Horse gram. Aqueous and ethanol extracts of seeds of Macrotyloma uniflorum were evaluated for their anti-inflammatory effects using the scientific protocol on experimental rats. Extraction was carried out using the cold maceration method, and the anti-inflammatory activity was evaluated using a digital plethysmometer in the experimental rats injected with carrageenan to produce paw edema. Preliminary phytochemical studies confirmed the presence of various bioactive compounds such as alkaloids, glycosides, carbohydrates, proteins and amino acids, terpenoids, tannins, and phenolic compounds in both extracts while flavonoids were found only in ethanol extract. Both extracts of M. uniflorum seeds (200 mg/ml) significantly (p<0.01) reduced the paw edema volume induced by carrageenan. The ethanol extract of M. uniflorum seeds exhibited more potent anti-inflammatory activity than water extract, that might be due to the presence of flavonoids in ethanol extract. The activity of the extracts was compared with diclofenac sodium (10mg/kg b.wt.) as a reference drug. From the results, it may be suggested that the antioxidative potential of phenolic constituents and flavonoids is the primary factors for the anti-inflammatory activity of M. uniflorum seeds extracts.

scholarly journals Dectin-2 mediates phagocytosis of Lactobacillus paracasei KW3110 and IL-10 production by macrophages

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mia Yoshikawa ◽  
Sayuri Yamada ◽  
Miho Sugamata ◽  
Osamu Kanauchi ◽  
Yuji Morita
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Interleukin 10 ◽  
Lactobacillus Paracasei ◽  
Binding Affinities ◽  
Antibody Treatment ◽  
Lectin Array ◽  
Specific Strain ◽  
Anti Inflammatory ◽  
Carbohydrate Chains

AbstractLactic acid bacteria (LAB) are most generally used as probiotics and some strains of LAB are known to have anti-inflammatory effects. A specific strain of lactic acid bacteria, Lactobacillus paracasei KW3110 (KW3110), activates macrophages to produce interleukin-10 (IL-10), an anti-inflammatory cytokine; however, the biological mechanism remains unclear. In this study, we showed that the amount of incorporated KW3110 into a macrophage cell line, RAW 264.7, was higher than other genetically related strains using fluorescence microscopy. RNA-seq analysis indicated that treatment of macrophages with KW3110 induced Dectin-2 gene expression, which is a pattern recognition receptor, recognizing α-mannose. In addition, antibody treatment and knock down of Dectin-2, or factors downstream in the signaling pathway, decreased the amount of incorporated KW3110 and IL-10 production. Substantial lectin array analysis also revealed that KW3110 had higher binding affinities to lectins, which recognize the carbohydrate chains comprised of α-mannose, than two other LAB. In conclusion, KW3110 is readily incorporated into macrophages, leading to IL-10 production. Dectin-2 mediated the phagocytosis of KW3110 into macrophages and this may be involved with the characteristic carbohydrate chains of KW3110.

scholarly journals Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models

2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Joung-Woo Hong ◽  
Ga-Eun Yang ◽  
Yoon Bum Kim ◽  
Seok Hyun Eom ◽  
Jae-Hwan Lew ◽  
...  
Keyword(s):  
Water Extract ◽  
Inflammatory Activity ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory Activity of the Water Extract of Sargassum fulvellum

KSBB Journal ◽  
2012 ◽  
Vol 27 (6) ◽  
pp. 325-329 ◽  
Author(s):  
Da-Hyun Jeong ◽  
Koth-Bong-Woo-Ri Kim ◽  
Bo-Kyeong Kang ◽  
Seul-A Jung ◽  
Hyun-Jee Kim ◽  
...  
Keyword(s):  
Water Extract ◽  
Inflammatory Activity ◽  
Sargassum Fulvellum ◽  
Anti Inflammatory
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