Anti-inflammatory properties of lactic acid bacteria producing superoxide dismutase

2008 ◽  
Vol 294 (1) ◽  
pp. G353-G353 ◽  
Author(s):  
Wei Han ◽  
Jean Fioramonti
Keyword(s):  
Superoxide Dismutase ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Anti Inflammatory

Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn's disease in mice

2011 ◽  
Vol 151 (3) ◽  
pp. 287-293 ◽  
Author(s):  
Jean Guy LeBlanc ◽  
Silvina del Carmen ◽  
Anderson Miyoshi ◽  
Vasco Azevedo ◽  
Fernando Sesma ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Crohn’S Disease ◽  
Lactic Acid ◽  
Crohn's Disease ◽  
Lactic Acid Bacteria

scholarly journals Dectin-2 mediates phagocytosis of Lactobacillus paracasei KW3110 and IL-10 production by macrophages

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mia Yoshikawa ◽  
Sayuri Yamada ◽  
Miho Sugamata ◽  
Osamu Kanauchi ◽  
Yuji Morita
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Interleukin 10 ◽  
Lactobacillus Paracasei ◽  
Binding Affinities ◽  
Antibody Treatment ◽  
Lectin Array ◽  
Specific Strain ◽  
Anti Inflammatory ◽  
Carbohydrate Chains

AbstractLactic acid bacteria (LAB) are most generally used as probiotics and some strains of LAB are known to have anti-inflammatory effects. A specific strain of lactic acid bacteria, Lactobacillus paracasei KW3110 (KW3110), activates macrophages to produce interleukin-10 (IL-10), an anti-inflammatory cytokine; however, the biological mechanism remains unclear. In this study, we showed that the amount of incorporated KW3110 into a macrophage cell line, RAW 264.7, was higher than other genetically related strains using fluorescence microscopy. RNA-seq analysis indicated that treatment of macrophages with KW3110 induced Dectin-2 gene expression, which is a pattern recognition receptor, recognizing α-mannose. In addition, antibody treatment and knock down of Dectin-2, or factors downstream in the signaling pathway, decreased the amount of incorporated KW3110 and IL-10 production. Substantial lectin array analysis also revealed that KW3110 had higher binding affinities to lectins, which recognize the carbohydrate chains comprised of α-mannose, than two other LAB. In conclusion, KW3110 is readily incorporated into macrophages, leading to IL-10 production. Dectin-2 mediated the phagocytosis of KW3110 into macrophages and this may be involved with the characteristic carbohydrate chains of KW3110.

Improvement of an experimental colitis in rats by lactic acid bacteria producing superoxide dismutase

2006 ◽  
Vol 12 (11) ◽  
pp. 1044-1052 ◽  
Author(s):  
Wei Han ◽  
Annick Mercenier ◽  
Afifa Ait-Belgnaoui ◽  
Sonia Pavan ◽  
Florence Lamine ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Experimental Colitis

scholarly journals Exploring the wound healing, anti-inflammatory, anti-pathogenic and proteomic effects of lactic acid bacteria on keratinocytes

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jessica Brandi ◽  
Samuele Cheri ◽  
Marcello Manfredi ◽  
Claudia Di Carlo ◽  
Virginia Vita Vanella ◽  
...  
Keyword(s):  
Wound Healing ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Anti Inflammatory

scholarly journals Probiotic Properties of Lactiplantibacillus plantarum LB5 Isolated from Kimchi Based on Nitrate Reducing Capability

Foods ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1777
Author(s):  
Hyejin Sohn ◽  
You Hyun Chang ◽  
Jong Hyeok Yune ◽  
Chang Hee Jeong ◽  
Dong Min Shin ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Mrna Expression ◽  
Inflammatory Cytokines ◽  
Pathogenic Bacteria ◽  
Probiotic Properties ◽  
Expression Levels ◽  
E Coli ◽  
Anti Inflammatory ◽  
Mrna Expression Levels

The purpose of this study was to investigate the probiotic properties of lactic acid bacteria isolated from Korean radish water kimchi (dongchimi). A total of 800 isolates of lactic acid bacteria were isolated from kimchi, and the strain having reduction and tolerance capability for nitrate and nitrite was selected and identified as Lactiplantibacillus plantarum LB5 (LPLB5) by 16S rRNA sequencing. LPLB5 showed higher tolerance to acidic pH values (pH 2.5), 0.3% bile salts, and heat treatment (40, 50, and 60 °C). Antibacterial activity showed strong inhibition against four food-borne pathogenic bacteria (E. coli O157:H7 ATCC 35150, Pseudomonas aeruginosa KCCM 12539, Listeria monocytogenes KCCM 40307, and Staphylococcus aureus ATCC 25923). The strain did not show any antibiotic resistance, β-hemolytic activity, or ability to produce β-glucuronidase. LPLB5 also exhibited a 30% auto-aggregation ability and 33–60% co-aggregation ability with four pathogenic bacteria (E. coli O157: H7 ATCC 35150, E. coli KCTC 2571, L. monocytogenes ATCC 51776, and S. aureus ATCC 25923). Moreover, the strain showed approximately 40% 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical- and 10% 2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical-scavenging activity. In cell culture studies, human colon epithelial cells (Caco-2) were treated with LPLB5 (106 and 107 CFU/mL); the bacteria showed more than 70% adherence onto and a 32% invasion rate into the Caco-2 cells. LPLB5 significantly decreased the mRNA expression levels of pro-inflammatory cytokines (interleukin-1 beta (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-α)) and increased the mRNA expression levels of anti-inflammatory cytokines (interleukin-4 (IL-4), interleukin-10 (IL-10), and interferon-gamma (IFN-γ)) in lipopolysaccharide-stimulated Caco-2 cells. Our data suggest that LPLB5 is safe and possesses probiotic, antioxidant, and anti-inflammatory activities.

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