scholarly journals Basic Function and Applications of Polyglycerol Dendrimers

Oleoscience ◽  
2017 ◽  
Vol 17 (5) ◽  
pp. 211-216
Author(s):  
Yosuke SUGIMOTO ◽  
Tooru OOYA
Keyword(s):  
Basic Function ◽  
Polyglycerol Dendrimers

The Logical and Compositional Organization of the Lecture (Based on a Lecture from M. Mamardashvili’s Course “Lectures on Proust”)

2020 ◽  
pp. 72-81
Author(s):  
Aleksandra A. Talanina ◽  
Keyword(s):  
Academic Discourse ◽  
Basic Function ◽  
Literary Language ◽  
Linguistic Features ◽  
Specific Nature ◽  
Teaching Process ◽  
Discourse Studies ◽  
Multi Level ◽  
Spatiotemporal Coordination ◽  
Different Levels

Functional and stylistic studies give us an idea of linguistic features of speech products, thus enabling style identification. These specific features become most recognizable when comparing styles. Discourse studies, on the contrary, are mainly focused on understanding and describing basic factors of creating a form of a literary language (style) and factors that determine the characteristics of speech products in individual situations within a socially significant sphere. This article presents an analysis of the logical and compositional organization of the lecture as a genre of academic discourse, taking a university lecture from M. Mamardashvili’s course on M. Proust as an example. The specific nature of the lecture genre in academic discourse is determined by its basic function in the teaching process implemented in direct dialogue with the audience. The research is based on the thesis that a lecture is an event that can be analysed using the concept of chronotope. The use of this concept beyond the analysis of fiction is relevant since spatiotemporal coordination is mandatory for any speech product, regardless of the sphere it is created in or the functions it performs. The main feature of the lecture chronotope is multi-level organization, since a lecture has its own internal spatiotemporal coordinates. The lecture chronotope is explicated at different levels of the text (compositional, lexical and grammatical), which are interconnected. Considering this, two interconnected frameworks of the lecture – structural and semantic – are singled out; they provide the logical and compositional organization of the material, which is important to ensure students’ understanding.

Prognostic Role of Hedgehog-GLI1 Signaling Pathway in Aggressive and Metastatic Breast Cancers

2020 ◽  
Vol 21 (1) ◽  
pp. 33-43 ◽  
Author(s):  
Prasuja Rokkam ◽  
Shailender Gugalavath ◽  
Deepak Kakara Gift Kumar ◽  
Rahul Kumar Vempati ◽  
Rama Rao Malla
Keyword(s):  
Breast Cancer ◽  
Signaling Pathway ◽  
Neural Development ◽  
Splice Variants ◽  
Metastatic Breast ◽  
Basic Function ◽  
Breast Cancers ◽  
Breast Cancer Patients ◽  
Aberrant Expression ◽  
Cellular Processes

Glioma-associated oncogene homolog 1 (GLI1) is reported as an amplified gene in human glioblastoma cells. It is a krupple like transcription factor, belonging to the zinc finger family. The basic function of GLI1 is normal neural development at various stages of human. The GLI1 gene was first mapped on the chromosome sub-bands 12q13.3-14.1. Further, single nucleotide polymorphism is mostly observed in translating a region of 5’ and 3’- UTR of GLI1 gene in addition to two post-transcriptional splice variants, GLIΔN and tGLI. Additionally, it also regulates a plethora of gene which mediates crucial cellular processes like proliferation, differentiation, oncogenesis, EMT, and metastasis. It also regulates tumor tolerance, chemoresistance, and radioresistance. Aberrant expression of GLI1 predicts the poor survival of breast cancer patients. GLI1 is an essential mediator of the SHH signaling pathway regulating self-renewal of stem cells, angiogenesis, and expression of FOXS1, CYR61. GLI1 mediated HH pathway can induce apoptosis. Hence, GLI1 can be a future diagnostic, prognostic marker, and as well as a potent target of therapeutics in breast cancer.

scholarly journals Biochemical and Initial Structural Characterization of the Monocot Chimeric Jacalin OsJAC1

2021 ◽  
Vol 22 (11) ◽  
pp. 5639
Author(s):  
Nikolai Huwa ◽  
Oliver H. Weiergräber ◽  
Christian Kirsch ◽  
Ulrich Schaffrath ◽  
Thomas Classen
Keyword(s):  
Physiological Role ◽  
Basic Function ◽  
Binding Activity ◽  
Carbohydrate Binding ◽  
Lectin Domain ◽  
Reducing Conditions ◽  
Transition Points ◽  
The Individual ◽  
High Yields ◽  
Dirigent Domain

The monocot chimeric jacalin OsJAC1 from Oryza sativa consists of a dirigent and a jacalin-related lectin domain. The corresponding gene is expressed in response to different abiotic and biotic stimuli. However, there is a lack of knowledge about the basic function of the individual domains and their contribution to the physiological role of the entire protein. In this study, we have established a heterologous expression in Escherichia coli with high yields for the full-length protein OsJAC1 as well as its individual domains. Our findings showed that the secondary structure of both domains is dominated by β-strand elements. Under reducing conditions, the native protein displayed clearly visible transition points of thermal unfolding at 59 and 85 °C, which could be attributed to the lectin and the dirigent domain, respectively. Our study identified a single carbohydrate-binding site for each domain with different specificities towards mannose and glucose (jacalin domain), and galactose moieties (dirigent domain), respectively. The recognition of different carbohydrates might explain the ability of OsJAC1 to respond to different abiotic and biotic factors. This is the first report of specific carbohydrate-binding activity of a DIR domain, shedding new light on its function in the context of this monocot chimeric jacalin.

scholarly journals Tackling Dysfunction of Mitochondrial Bioenergetics in the Brain

2021 ◽  
Vol 22 (15) ◽  
pp. 8325
Author(s):  
Paola Zanfardino ◽  
Stefano Doccini ◽  
Filippo M. Santorelli ◽  
Vittoria Petruzzella
Keyword(s):  
Human Brain ◽  
Basic Function ◽  
Mitochondrial Proteome ◽  
Novel Proteins ◽  
Mitochondrial Functions ◽  
Organ Specific ◽  
Oxphos System ◽  
Mitochondrial Defects ◽  
Energy Dependent ◽  
The Brain

Oxidative phosphorylation (OxPhos) is the basic function of mitochondria, although the landscape of mitochondrial functions is continuously growing to include more aspects of cellular homeostasis. Thanks to the application of -omics technologies to the study of the OxPhos system, novel features emerge from the cataloging of novel proteins as mitochondrial thus adding details to the mitochondrial proteome and defining novel metabolic cellular interrelations, especially in the human brain. We focussed on the diversity of bioenergetics demand and different aspects of mitochondrial structure, functions, and dysfunction in the brain. Definition such as ‘mitoexome’, ‘mitoproteome’ and ‘mitointeractome’ have entered the field of ‘mitochondrial medicine’. In this context, we reviewed several genetic defects that hamper the last step of aerobic metabolism, mostly involving the nervous tissue as one of the most prominent energy-dependent tissues and, as consequence, as a primary target of mitochondrial dysfunction. The dual genetic origin of the OxPhos complexes is one of the reasons for the complexity of the genotype-phenotype correlation when facing human diseases associated with mitochondrial defects. Such complexity clinically manifests with extremely heterogeneous symptoms, ranging from organ-specific to multisystemic dysfunction with different clinical courses. Finally, we briefly discuss the future directions of the multi-omics study of human brain disorders.

scholarly journals Chemistry of Indoles carrying a Basic Function. Part 5.1 Some Observations while Constructing an Ergoline Ring by Stobbe Reaction

1999 ◽  
Vol 23 (12) ◽  
pp. 687-687
Author(s):  
István Moldvai ◽  
Eszter Temesvári-Major ◽  
Mihály Balázs ◽  
Eszter Gács-Baitz ◽  
Orsolya Egyed ◽  
...  
Keyword(s):  
Indole Derivative ◽  
Basic Function ◽  
Reaction Conditions

Tricyclic indole derivative 11 affords the imide 12 under Stobbe reaction conditions rather than the expected intermediate containing an ergoline ring.

scholarly journals Packet Flow Based Reinforcement Learning MAC Protocol for Underwater Acoustic Sensor Networks

Sensors ◽  
2021 ◽  
Vol 21 (7) ◽  
pp. 2284
Author(s):  
Ibrahim B. Alhassan ◽  
Paul D. Mitchell
Keyword(s):  
Sensor Networks ◽  
Mac Protocol ◽  
Propagation Delay ◽  
Basic Function ◽  
Acoustic Sensor ◽  
Underwater Acoustic Sensor Networks ◽  
Medium Access ◽  
Underwater Acoustic ◽  
Q Learning ◽  
Acoustic Sensor Networks

Medium access control (MAC) is one of the key requirements in underwater acoustic sensor networks (UASNs). For a MAC protocol to provide its basic function of efficient sharing of channel access, the highly dynamic underwater environment demands MAC protocols to be adaptive as well. Q-learning is one of the promising techniques employed in intelligent MAC protocol solutions, however, due to the long propagation delay, the performance of this approach is severely limited by reliance on an explicit reward signal to function. In this paper, we propose a restructured and a modified two stage Q-learning process to extract an implicit reward signal for a novel MAC protocol: Packet flow ALOHA with Q-learning (ALOHA-QUPAF). Based on a simulated pipeline monitoring chain network, results show that the protocol outperforms both ALOHA-Q and framed ALOHA by at least 13% and 148% in all simulated scenarios, respectively.

Research on the Optimal Design Method of the Main Components for the Wheelchair Pickup

2013 ◽  
Vol 791-793 ◽  
pp. 799-802
Author(s):  
Ya Ping Wang ◽  
H.R. Shi ◽  
L. Gao ◽  
Z. Wang ◽  
X.Y. Jia ◽  
...  
Keyword(s):  
Parametric Design ◽  
Design Method ◽  
Basic Function ◽  
Design Parameters ◽  
Algorithm Optimization ◽  
Optimization Analysis ◽  
Research Designs ◽  
Optimal Design Method ◽  
Main Components

With the increasing of the aging of population all over the world, and With the inconvenience coming from diseases and damage, there will be more and more people using the wheelchair as a tool for transport. When it cant be short of the wheelchair in the daily life, the addition of the function will bring the elevation of the quality of life for the unfortunate. Staring with this purpose, the research designs a pickup with planetary bevel gear for the wheelchair. After determining the basic function of the wheelchair aids, the study determines the design parameters by using the knowledge of parametric design and completes the model for the system with Pro/E, on the other hand, it completes key components optimization analysis which is based on genetic algorithm optimization.

A Mathematical Principle and Application on Design of Planar Six-Bar Mechanism with unto Three-Ordered Intermission at Limit Position(s)

2010 ◽  
Vol 37-38 ◽  
pp. 9-13
Author(s):  
Hong Xin Wang ◽  
Ning Dai
Keyword(s):  
Design Method ◽  
Optimization Method ◽  
Basic Function ◽  
Mathematical Principle ◽  
Transmission Characteristics ◽  
Basic Functions ◽  
Combined Mechanism ◽  
Limit Position ◽  
Derivatives Of ◽  
Better Than

A non-iterative design method about high order intermittent mechanisms is presented. The mathematical principle is that a compound function produced by two basic functions, and then one to three order derivatives of the compound function are all zeroes when one order derivative of each basic function is zero at the same moment. The design method is that a combined mechanism is constructed by six bars; the displacement functions of the front four-bar and back four-bar mechanisms are separately built, let one order derivatives of two displacement functions separately be zero at the same moment, and then get geometrical relationships and solution on the intermittent mechanism. A design example shows that this method is simpler and transmission characteristics are better than optimization method.

What Can Be Learned from Smeets and Brenner's Model about the Control of Grasping?

Motor Control ◽  
1999 ◽  
Vol 3 (3) ◽  
pp. 302-306 ◽  
Author(s):  
Bert Steenbergen
Keyword(s):  
Boundary Condition ◽  
Velocity Profile ◽  
Visual Feedback ◽  
Basic Function ◽  
Present Form ◽  
Object Properties ◽  
Transport Component ◽  
Proposed Model

The present reaction on the paper of Smeets and Brenner focuses on two premises of their proposed model The first is that grasping is nothing more than pointing with two fingers. It is argued that this assumption cannot be upheld in light of the differences between both actions with respect to neuromuscular structures, muscular innervation, use of visual feedback, and basic function The second premise of the model is that the velocity profile of the transport component is symmetrical and independent of intrinsic object properties. It is shown that the symmetrical velocity profile represents a boundary condition and is influenced by intrinsic object properties. Given these concerns, it is doubtful that the model in its present form will add much to our understanding of the control of grasping.

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