Evaluation of Precision and Splitting Time of Preparation Assistance Devices for Use in Tablet Splitting

2019 ◽  
Vol 45 (7) ◽  
pp. 409-415
Author(s):  
Junya Sato ◽  
Megumi Endo ◽  
Yuki Yamawaki ◽  
Takayuki Tuchiya ◽  
Yoshiko Kamo ◽  
...  
Keyword(s):  
Tablet Splitting ◽  
Splitting Time

scholarly journals Comparison of Some Physical Parameters of Whole and Scored Lisinopril and Lisinopril/Hydrochlorthiazide Tablets

2008 ◽  
Vol 8 (4) ◽  
pp. 391-395 ◽  
Author(s):  
Edina Vranić ◽  
Alija Uzunović
Keyword(s):  
Large Scale ◽  
Testing Procedure ◽  
Physical Parameters ◽  
Hardness Testing ◽  
Disintegration Time ◽  
Adequate Dose ◽  
Response Information ◽  
Tablet Splitting ◽  
Good Patient Compliance ◽  
Accepted Practice

Tablets are one of the most popular and preferred solid dosage forms because they can be accurately dosed, easily manufactured and packaged on a large scale, have good physical and chemical stability, and can contribute to good patient compliance given their ease of administration. The ability to match doses to patients depends on the availability of multiple dose sizes and adequate dose-response information. These are not always provided, so splitting of the tablets is sometimes necessary, Tablet splitting is an accepted practice in dispensing medication, It has been used when a dosage form of the required strength is not available commercially. The aim of our study was to compare some physical parameters of whole and scored lisinopril and lisinopril/hydrochlorthiazide tablets and to accept or exclude their influence on the obtaining of required dosage.According to the results obtained, we may conclude that tablets from batch “I” “IL “III” and “IV” satisfied pharmacopeial requirements concerning crushing strength, friability, disintegration time and mass uniformity. The hardness testing showed acceptable reproducibility and indicate that the data variation was primarily from the irreversible changes in the structure of tablet samples. The act of compacting powders stores energy within the tablets, by shifting or compressing the intermolecular bonds within the particles. The tablets have a natural tendency to relax once pressure is removed, and this tendency works against the interparticle bonding formed during compression. Hardness testing procedure causes irreversible changes in this structure.

scholarly journals Forecasting and Analysis Tools for Regional Industries’ Dynamics

2021 ◽  
Vol 5 (1) ◽  
pp. 1
Author(s):  
Valeriy Semenychev ◽  
Anastasiya Korobetskaya
Keyword(s):  
Decision Making ◽  
Evolutionary Dynamics ◽  
Forecast Accuracy ◽  
High Accuracy ◽  
General Idea ◽  
Russian Regions ◽  
Seasonal Component ◽  
Modeling Analysis ◽  
Splitting Time ◽  
Regions Of Russia

The article is devoted to the author’s approach and tools for regional industries’ modeling, analysis and forecasting, following the general idea of splitting time series into four components: trend, cycles, seasonal component, and residuals. However, the authors introduce new approaches, models, metrics, and identification algorithms, and the components’ interaction structures, having included the analysis of 12 industries in 82 regions of Russia. The models and forecast accuracy were tested on 3–12 month forecasts, thus proving their high accuracy. Therefore, the article proposes not only new systematic econometric tools but a methodology for decision making, developed to provide stable and adequate characteristics of complex non-linear evolutionary dynamics of Russian regions.

Tablet splitting: Product quality assessment of metoprolol succinate extended release tablets

2010 ◽  
Vol 401 (1-2) ◽  
pp. 25-31 ◽  
Author(s):  
Na Zhao ◽  
Ahmed Zidan ◽  
Mobin Tawakkul ◽  
Vilayat A. Sayeed ◽  
Mansoor Khan
Keyword(s):  
Quality Assessment ◽  
Product Quality ◽  
Extended Release ◽  
Metoprolol Succinate ◽  
Tablet Splitting

scholarly journals Using Joinpoint Regression for the Analysis of Trends in Syphilis Incidence in Poland in the Years 1950–2017

2019 ◽  
Vol 60 (1) ◽  
pp. 7-18
Author(s):  
Marcin Milewski ◽  
Rafał Milewski ◽  
Gabriela Sokołowska ◽  
Anna Justyna Milewska
Keyword(s):  
Transmitted Disease ◽  
Treponema Pallidum ◽  
Epidemiological Studies ◽  
Sexual Contact ◽  
Regression Method ◽  
Serological Response ◽  
Joinpoint Regression ◽  
Sexually Transmitted ◽  
The Impact ◽  
Splitting Time

Abstract Syphilis is a bacterial sexually transmitted disease (STD), whose main route of infection is through sexual contact. In order to diagnose syphilis, Treponema pallidum must be detected in the material sampled from a lesion and a blood test must be performed in order to detect serological response to syphilis. Since 1946, a statutory obligation to report all cases of syphilis has been in force in Poland, which is why data concerning the incidence is available. The aim of this paper is to analyse trends in syphilis incidence in the years 1950–2017 using Joinpoint Regression and to present the impact of prophylaxis and education of society on syphilis prevention. The Joinpoint Regression method indicated the splitting time points of the trend corresponding to real changes in incidence, which corroborates the purpose of using the method in question in epidemiological studies.

scholarly journals Tablet Scoring: Current Practice, Fundamentals, and Knowledge Gaps

2019 ◽  
Vol 9 (15) ◽  
pp. 3066 ◽  
Author(s):  
Emmanuel Reginald Jacques ◽  
Paschalis Alexandridis
Keyword(s):  
Prescription Drugs ◽  
In Vitro Test ◽  
Dose Administration ◽  
Solid Dosage ◽  
Non Invasive ◽  
Health Care Practitioners ◽  
Tablet Splitting ◽  
Vitro Test

Oral solid dosage formulations and/or tablets have remained the preferred route of administration by both patients and health care practitioners. Oral tablets are easy to administer, they are non-invasive and cause less risk adversity. Because of the lack of commercially available tablet dose options, tablets are being split or partitioned by users. Tablet scoring refers to the breakage of a tablet to attain a desired efficacy dose and is an emerging concept in the pharmaceutical industry. The primary reason for the tablet scoring practice is to adjust the dose: dose tapering or dose titrating. Other reasons for tablet partitioning are to facilitate dose administration, particularly among the pediatric and the geriatric patient population, and to mitigating the high cost of prescription drugs. The scope of this review is to: (1) evaluate the advantages and inconveniences associated with tablet scoring/portioning, and (2) identify factors in the formulation and the manufacturing of tablets that influence tablet splitting. Whereas tablet partitioning has been a common practice, there is a lack of understanding regarding the fundamentals underpinning the performance of tablets with respect to splitting. Several factors can influence tablet partitioning: tablet size, shape, and thickness. A requirement has recently been set by the European Pharmacopoeia and the U.S. Food and Drug Administration for the uniformity of mass of subdivided tablets. For breaking ease, an in-vivo reference test and a routinely applicable in-vitro test need to be established.

Evaluation of Tablet Splitting Methods: A Case Study of Propranolol

2021 ◽  
pp. 511-520
Author(s):  
Irma Mureškić ◽  
Božana Jevđenić ◽  
Kanita Muhamedagić ◽  
Anđelka Račić ◽  
Biljana Gatarić ◽  
...  
Keyword(s):  
Splitting Methods ◽  
Tablet Splitting

scholarly journals Tablet Splitting Performance Evaluation of Losartan Potassium and Olmesartan Medoxomil IR Tablets Marketed in Bangladesh

2020 ◽  
Vol 23 (2) ◽  
pp. 146-154
Author(s):  
Saimon Shahriar ◽  
Abu Asad Chowdhury ◽  
Md Shah Amran ◽  
Jakir Ahmed Chowdhury
Keyword(s):  
Performance Evaluation ◽  
Olmesartan Medoxomil ◽  
Pharmaceutical Journal ◽  
Losartan Potassium ◽  
Pharmaceutical Companies ◽  
Weight Variation ◽  
Loss Of Weight ◽  
Tablet Splitting ◽  
Conclusive Data

Tablet splitting is a widely used practice in Bangladesh but there are no regulations for pharmaceutical companies to ensure that tablets are manufactured in such a way that facilitates appropriate splitting. Seven Losartan Potassium (LSP) brands and five Olmesartan Medoxomil (OLM) brands were selected and necessary number of tablets as well as a tablet splitter was collected. Weight variation, assay, invitro dissolution and loss of weight parameters were evaluated according to recent guidelines on the tablet fractions split by hand and by the splitter separately. Seven out of twelve brands displayed acceptable results in all parameter evaluations. EP and USP standards produced dissimilar results. In all assessments, machine-split portions produced better results than hand-split ones and so, a tablet splitter was found to be more reliable than using hands only. This study is preliminary in nature and thus further extensive studies are in progress involving more samples, more personnel and more laboratories as well as utilizing properly validated methodology and precisely calibrated instruments to get more conclusive data. Bangladesh Pharmaceutical Journal 23(2): 146-154, 2020

The Research of Splitting Craft for Air Filter with Sea-Island Superfine Fiber Needled Fabrics

2013 ◽  
Vol 303-306 ◽  
pp. 2567-2571 ◽  
Author(s):  
Ling Xiao Jing ◽  
Sheng Sun ◽  
Xin Wang ◽  
Cai Qian Zhang
Keyword(s):  
Loss Rate ◽  
High Efficiency ◽  
Fine Particles ◽  
Orthogonal Design ◽  
Low Cost ◽  
Dust Collector ◽  
Air Filter ◽  
Ultra Fine Particles ◽  
Superfine Fiber ◽  
Splitting Time

Although the bag-type dust collector is dust capture equipment which is low cost and high efficiency, it has less filter efficiency to ultra fine particles for its of thicker fiber. So ultrafine fiber were used by bicomponent fiber with splitting craft to improve the filtration efficiency of ultra fine particles greatly. A piece of polyester/nylon sea-island superfine fiber needled nonwovens were splitted processing for nine times by the orthogonal design. And fibre microscopic photographs, weight loss rate and strength were analyzed. The best choice of splitting craft as followed: lye concentration is 16%, splitting time 15 min and splitting temperature is 95 °C.

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