scholarly journals SPASMOLYTIC ACTIVITY OF THE AQUEOUS AND ETHANOL CELERY LEAVES (APIUM GRAVEOLENS L.) EXTRACTS ON THE CONTRACTION OF ISOLATED RAT ILEUM

2015 ◽  
pp. 11-16 ◽  
Author(s):  
Suzana Branković ◽  
Marija Gočmanac-Ignjatović ◽  
Milica Kostić ◽  
Milica Veljković ◽  
Bojana Miladinović ◽  
...  
Keyword(s):  
Apium Graveolens ◽  
Spasmolytic Activity ◽  
Rat Ileum ◽  
Isolated Rat

scholarly journals Spasmolytic Activity of the Ethanol Extract of Sideritis raeseri spp. raeseri Boiss. & Heldr. on the Isolated Rat Ileum Contractions

2011 ◽  
Vol 14 (5) ◽  
pp. 495-498 ◽  
Author(s):  
Suzana Brankovic ◽  
Dusanka Kitic ◽  
Mirjana Radenkovic ◽  
Slavimir Veljkovic ◽  
Teodora Jankovic ◽  
...  
Keyword(s):  
Ethanol Extract ◽  
Spasmolytic Activity ◽  
Rat Ileum ◽  
Isolated Rat

scholarly journals Antispasmodic Effect of Blackcurrant (Ribes nigrum L.) Juice and Its Potential Use as Functional Food in Gastrointestinal Disorders

2018 ◽  
Vol 27 (2) ◽  
pp. 179-185 ◽  
Author(s):  
Bojana Miladinovic ◽  
Suzana  Brankovic ◽  
Milica Kostic ◽  
Milica Milutinovic ◽  
Nemanja Kitic ◽  
...  
Keyword(s):  
Functional Food ◽  
Statistical Significance ◽  
Barium Chloride ◽  
Gastrointestinal Disorders ◽  
Spasmolytic Activity ◽  
Rat Ileum ◽  
Antispasmodic Effect ◽  
Spontaneous Contractions ◽  
Isolated Rat

Objective: The purpose of this study was to investigate the relaxative effects of blackcurrant juice on the gastrointestinal smooth muscle in vitro. Materials and Methods: Berries of the blackcurrant cultivar Ometa were used for the preparation of the juice used. The spasmolytic activity of blackcurrant juice was tested on rat ileum isolated from male Wistar rats by monitoring its influence on spontaneous contractions, as well as contractions induced by potassium chloride (KCl), barium chloride (BaCl2), calcium chloride (CaCl2), and acetylcholine (Ach). The results are expressed as the mean ± standard deviation obtained in 6 measurements and statistical significance was determined by the Student t test, with p < 0.05 taken as significant. Results: The blackcurrant cultivar Ometa significantly reduced the frequency and the amplitude of spontaneous contractions (57.94 ± 3.44%) and Ach-induced contractions (42.74 ± 5.36%; p < 0.05) of the isolated rat ileum. Cumulative concentrations (0.01–3 mg/mL) of the Ometa juice also reduced contractions of the isolated rat ileum stimulated by KCl (51.46 ± 6.87%), CaCl2 (57.54 ± 6.47%), and BaCl2 (58.54 ± 10.55%). The inhibitory effects of the juice were proportional to the applied concentration. Conclusion: The antispasmodic effect of Ometa cultivar shows that common gastrointestinal disorders could be treated by the functional food.

Spasmolytic activity of Phagnalon saxatile (L.) Cass. on the isolated rat ileum

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
G Aviello ◽  
D Rigano ◽  
C Formisano ◽  
R Capasso ◽  
AA Izzo ◽  
...  
Keyword(s):  
Spasmolytic Activity ◽  
Rat Ileum ◽  
Isolated Rat

Comparative spasmolytic effect between Cinnamomum tamala and Cinnamomum verum leaf essential oils and eugenol through in vitro and in silico approaches

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Anubhav Chakraborty ◽  
Vishwam Sankaran ◽  
Ramar Murugan ◽  
David Raj Chellappan
Keyword(s):  
Essential Oils ◽  
In Silico ◽  
Pharmacological Action ◽  
Lower Content ◽  
Nicotinic Acetylcholine ◽  
Spasmolytic Activity ◽  
Rat Ileum ◽  
Cinnamomum Tamala ◽  
Isolated Rat

Abstract Cinnamomum tamala and Cinnamomum verum are known for their folk medicinal usage in treating gastrointestinal ailments. The spasmolytic activity of essential oils was studied using isolated rat ileum. The results indicate that C. tamala, despite having a lower content of eugenol (60%), shows a spasmolytic potential of 68.01 ± 2.63% (EC50 = 110.12 ± 13.58 μg/mL) while C. verum with rich eugenol (80%) shows lesser spasmolytic potential (38.96 ± 0.63%) and fails to attain an EC50 value. Upon comparison with standard eugenol’s percentage of spasmolytic (35.68 ± 2.57%), it is evident that the action of these essential oils does not solely rely on the major component but the synergistic role in association with other components of the mixture influences the pharmacological action of the essential oils. In silico docking of phytochemicals of leaf essential oils with M2 (M2AChR) and M3 muscarinic (M3AChR) and nicotinic acetylcholine receptor (nAChR) was carried out to determine the type of receptors through which the essential oils had spasmolytic potential. The binding affinity for eugenol with nAChR shows a better docking score than M2AChR and M3AChR.

Relaxant effect of capsazepine in the isolated rat ileum

2002 ◽  
Vol 365 (3) ◽  
pp. 187-192 ◽  
Author(s):  
Emilia Nocerino ◽  
Angelo Izzo ◽  
Francesca Borrelli ◽  
Francesco Capasso ◽  
Raffaele Capasso ◽  
...  
Keyword(s):  
Relaxant Effect ◽  
Rat Ileum ◽  
Isolated Rat

scholarly journals Induction of functional activity and expression of mRNA of kinin B1 receptor in isolated rat ileum

2000 ◽  
Vol 82 ◽  
pp. 276
Author(s):  
Mineka Yoshimura ◽  
Hiroaki Naraba ◽  
Akinori Ueno ◽  
Sachiko Oh-ishi
Keyword(s):  
Functional Activity ◽  
Rat Ileum ◽  
B1 Receptor ◽  
Kinin B1 Receptor ◽  
Isolated Rat

Enkephalin-induced inhibition of the isolated rat ileum is not blocked by naloxone

1981 ◽  
Vol 59 (8) ◽  
pp. 901-903 ◽  
Author(s):  
K. Nakatsu ◽  
E. Goldenberg ◽  
D. Penning ◽  
K. Jhamandas
Keyword(s):  
Dependent Manner ◽  
Narcotic Antagonist ◽  
Concentration Dependent Manner ◽  
Rat Ileum ◽  
Leucine Enkephalin ◽  
Isolated Rat

Both methionine- and leucine-enkephalin caused the isolated rat ileum to relax in a concentration-dependent manner; the EC50 values were in the order of 10−8 to 10−7 M. This isolated preparation was generally not sensitive to morphine. The enkephalin-induced inhibitions were not blocked by the classical narcotic antagonist, naloxone.

In VitroExamination of Potentized Atropine Sulfate Dilutions on the Contractility of the Isolated Rat Ileum

2009 ◽  
Vol 15 (10) ◽  
pp. 1121-1126 ◽  
Author(s):  
Christiane Siegling-Vlitakis ◽  
Holger Martens ◽  
Rainer Lüdtke
Keyword(s):  
Atropine Sulfate ◽  
Rat Ileum ◽  
Isolated Rat
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