scholarly journals Therapeutic hypothermia in asphyxiated newborns: selective head cooling vs. whole body cooling — comparison of short term outcomes

2019 ◽  
Vol 90 (7) ◽  
pp. 403-410 ◽  
Author(s):  
Ewa Matylda Gulczynska ◽  
Janusz Gadzinowski ◽  
Marcin Kesiak ◽  
Barbara Sobolewska ◽  
Joanna Caputa ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Whole Body ◽  
Short Term ◽  
Head Cooling ◽  
Body Cooling ◽  
Whole Body Cooling

scholarly journals Comparison of selective head cooling therapy and whole body cooling therapy in newborns with hypoxic ischemic encephalopathy: Short term results

2015 ◽  
Vol 50 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Aytug Atici ◽  
Yalcin Celik ◽  
Selvi Gulasi ◽  
Ali Haydar Turhan ◽  
Cetin Okuyaz ◽  
...  
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Whole Body ◽  
Short Term ◽  
Head Cooling ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Ischemic Encephalopathy

Subcutaneous fat necrosis, a rare but serious side effect of hypoxic-ischemic encephalopathy and whole-body hypothermia

2019 ◽  
Vol 47 (9) ◽  
pp. 986-990 ◽  
Author(s):  
Mahdi Alsaleem ◽  
Lina Saadeh ◽  
Valerie Elberson ◽  
Vasantha H.S. Kumar
Keyword(s):  
Therapeutic Hypothermia ◽  
Subcutaneous Fat ◽  
Whole Body ◽  
Subcutaneous Fat Necrosis ◽  
P Values ◽  
Life Threatening ◽  
The Mean ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Ischemic Encephalopathy

Abstract Objective To describe the clinical characteristics and risk factors in infants with subcutaneous fat necrosis (SFN) following therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE). Methods A case-control study was performed by a retrospective chart review of infants with moderate or severe HIE admitted to a level IV regional perinatal center and who underwent whole-body cooling. Results A total of 14 (8.1%) of 171 infants with moderate or severe HIE who underwent whole-body cooling developed SFN during hospitalization. There were more females [71% (10/14)] and large-for-gestational age (LGA) infants [28% (4/14)] in the SFN group vs. 36% females (57/157) and 8% LGA infants (13/157) in the group without SFN (P-values of 0.009 and 0.015, respectively). The mean lowest platelet count was lower 108 ± 55 109/L vs. 146 ± 62 109/L and the mean highest calcium level was higher 11.3 ± 2.5 vs. 10.6 ± 0.8 mg/dL in infants with SFN vs. infants without SFN, respectively (P-values of 0.0078 and 0.006, respectively). Distribution of skin lesions followed distinctive patterns representing the areas with direct contact with the cooling blanket. One infant developed severe, life-threatening hypercalcemia that required aggressive management, including diuretics, corticosteroids and bisphosphonates. Conclusion Although SFN is a rare complication of therapeutic hypothermia, it can be a life-threatening condition if complicated by severe hypercalcemia. Infants who undergo therapeutic hypothermia for HIE need regular skin examinations to evaluate for SFN. If SFN is identified, monitoring of serum calcium levels to prevent life-threatening hypercalcemia is recommended.

scholarly journals Systemic effects of whole-body cooling to 35 °C, 33.5 °C, and 30 °C in a piglet model of perinatal asphyxia: implications for therapeutic hypothermia

2012 ◽  
Vol 71 (5) ◽  
pp. 573-582 ◽  
Author(s):  
Aron Kerenyi ◽  
Dorottya Kelen ◽  
Stuart D. Faulkner ◽  
Alan Bainbridge ◽  
Manigandan Chandrasekaran ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Perinatal Asphyxia ◽  
Whole Body ◽  
Systemic Effects ◽  
Body Cooling ◽  
Whole Body Cooling

scholarly journals Outcome of Infants with Hypoxic-Ischemic Encephalopathy Treated by Whole Body Cooling and Magnesium Sulfate

2021 ◽  
Vol 11 (01) ◽  
pp. e280-e286
Author(s):  
Safwat M. Abdel-Aziz ◽  
Mohamed Sabry M. Abdel Rahman ◽  
Asmaa H. Shoreit ◽  
Moustafa Ez El Din ◽  
Enas A. Hamed ◽  
...  
Keyword(s):  
Magnesium Sulfate ◽  
Therapy Group ◽  
Whole Body ◽  
P Value ◽  
Short Term ◽  
Group 3 ◽  
Group 2 ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Group 1

AbstractTherapeutic hypothermia (TH) either by selective head cooling or whole-body cooling decreases brain damage and provide neuroprotection and reduced mortality rate in cases of moderate-to-severe hypoxia-ischemia encephalopathy (HIE) of newborns, especially if started at first 6 hours after birth. Also, management with adjuvant therapies like magnesium sulfate (MS) provides more neuroprotection. The interventional randomized controlled research aimed to assess short-term actions of TH as sole therapy and in combination with MS as a neuroprotective agent for the treatment of HIE newborn infants. A total of 36 full-terms and near-term infants delivered at Assiut University Children's Hospital and fulfilled HIE criteria were enrolled. They were divided equally into three groups; Group 1 (n = 12) received whole body cooling during first 6 hours of life as a sole therapy; Group 2 (n = 12) received whole body cooling in addition to MS as adjuvant therapy; Group 3 (n = 12) received supportive intensive care measures as a control. TH plus MS group (group 2) had a significantly good short-term outcomes as short period of respiratory support and mechanical ventilation (p-value =0.001), less in incidence of convulsion (p-value = 0.001) and early in feeding initiation (p-value = 0.009), compared with other groups managed by TH (group 1) or by supportive treatment (group 3). In conclusion, whole body cooling in addition to MS as adjunctive therapy for the treatment of HIE neonates is safe therapy that improves short-term outcome both clinically and radiologically.

scholarly journals Effects of face/head and whole body cooling during passive heat stress on human somatosensory processing

2017 ◽  
Vol 312 (6) ◽  
pp. R996-R1003 ◽  
Author(s):  
Hiroki Nakata ◽  
Mari Namba ◽  
Ryusuke Kakigi ◽  
Manabu Shibasaki
Keyword(s):  
Blood Flow ◽  
Heat Stress ◽  
Neural Activity ◽  
Whole Body ◽  
Somatosensory Processing ◽  
Esophageal Temperature ◽  
Passive Heating ◽  
Head Cooling ◽  
Body Cooling ◽  
Whole Body Cooling

We herein investigated the effects of face/head and whole body cooling during passive heat stress on human somatosensory processing recorded by somatosensory-evoked potentials (SEPs) at C4′ and Fz electrodes. Fourteen healthy subjects received a median nerve stimulation at the left wrist. SEPs were recorded at normothermic baseline (Rest), when esophageal temperature had increased by ~1.2°C (heat stress: HS) during passive heating, face/head cooling during passive heating (face/head cooling: FHC), and after HS (whole body cooling: WBC). The latencies and amplitudes of P14, N20, P25, N35, P45, and N60 at C4′ and P14, N18, P22, and N30 at Fz were evaluated. Latency indicated speed of the subcortical and cortical somatosensory processing, while amplitude reflected the strength of neural activity. Blood flow in the internal and common carotid arteries (ICA and CCA, respectively) and psychological comfort were recorded in each session. Increases in esophageal temperature due to HS significantly decreased the amplitude of N60, psychological comfort, and ICA blood flow in the HS session, and also shortened the latencies of SEPs (all, P < 0.05). While esophageal temperature remained elevated, FHC recovered the peak amplitude of N60, psychological comfort, and ICA blood flow toward preheat baseline levels as well as WBC. However, the latencies of SEPs did not recover in the FHC and WBC sessions. These results suggest that impaired neural activity in cortical somatosensory processing during passive HS was recovered by FHC, whereas conduction velocity in the ascending somatosensory input was accelerated by increases in body temperature.

scholarly journals The effects of selective head cooling versus whole-body cooling on some neural and inflammatory biomarkers: a randomized controlled pilot study

2015 ◽  
Vol 41 (1) ◽  
Author(s):  
Yalçın Çelik ◽  
Aytuğ Atıcı ◽  
Selvi Gülaşı ◽  
Khatuna Makharoblıdze ◽  
Gülçin Eskandari ◽  
...  
Keyword(s):  
Pilot Study ◽  
Inflammatory Biomarkers ◽  
Whole Body ◽  
Randomized Controlled ◽  
Head Cooling ◽  
Body Cooling ◽  
Whole Body Cooling

scholarly journals Exogenous Ketone Salt Supplementation and Whole-Body Cooling Do Not Improve Short-Term Physical Performance

2021 ◽  
Vol 8 ◽  
Author(s):  
Daniel Clark ◽  
Stephanie Munten ◽  
Karl-Heinz Herzig ◽  
Dominique D. Gagnon
Keyword(s):  
Steady State ◽  
Venous Blood ◽  
Time Trial ◽  
Whole Body ◽  
Short Term ◽  
Before And After ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Single Blind ◽  
Trial Performance

Exogenous ketone supplementation and whole-body cooling (WBC) have shown to independently influence exercise metabolism. Whether readily available ketone salts, with and without WBC, would provide similar metabolic benefits during steady-state aerobic and time-trial performances was investigated. Nine active males (VO2peak: 56.3 ± 2.2 mL·kg−1·min−1) completed three single-blind exercise sessions preceded by: (1) ingestion of placebo (CON), (2) ketone supplementation (0.3 g·kg−1 β-OHB) (KET), and (3) ketone supplementation with WBC (KETCO). Participants cycled in steady-state (SS, 60% Wmax) condition for 30-min, immediately followed by a 15-min time trial (TT). Skin and core temperature, cardio-metabolic, and respiratory measures were collected continuously, whereas venous blood samples were collected before and after supplementation, after SS and TT. Venous β-OHB was elevated, while blood glucose was lower, with supplementation vs. CON (p &lt; 0.05). TT power output was not different between conditions (p = 0.112, CON: 190 ± 43.5 W, KET: 185 ± 40.4 W, KETCO: 211 ± 50.7 W). RER was higher during KETCO (0.97 ± 0.09) compared to both CON (0.88 ± 0.04, p = 0.012) and KET (0.88 ± 0.05, p = 0.014). Ketone salt supplementation and WBC prior to short-term exercise sufficiently increase blood β-OHB concentrations, but do not benefit metabolic shifts in fuel utilization or improve time trial performance.

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