scholarly journals Systemic effects of whole-body cooling to 35 °C, 33.5 °C, and 30 °C in a piglet model of perinatal asphyxia: implications for therapeutic hypothermia

2012 ◽  
Vol 71 (5) ◽  
pp. 573-582 ◽  
Author(s):  
Aron Kerenyi ◽  
Dorottya Kelen ◽  
Stuart D. Faulkner ◽  
Alan Bainbridge ◽  
Manigandan Chandrasekaran ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Perinatal Asphyxia ◽  
Whole Body ◽  
Systemic Effects ◽  
Body Cooling ◽  
Whole Body Cooling

Subcutaneous fat necrosis, a rare but serious side effect of hypoxic-ischemic encephalopathy and whole-body hypothermia

2019 ◽  
Vol 47 (9) ◽  
pp. 986-990 ◽  
Author(s):  
Mahdi Alsaleem ◽  
Lina Saadeh ◽  
Valerie Elberson ◽  
Vasantha H.S. Kumar
Keyword(s):  
Therapeutic Hypothermia ◽  
Subcutaneous Fat ◽  
Whole Body ◽  
Subcutaneous Fat Necrosis ◽  
P Values ◽  
Life Threatening ◽  
The Mean ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
Ischemic Encephalopathy

Abstract Objective To describe the clinical characteristics and risk factors in infants with subcutaneous fat necrosis (SFN) following therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE). Methods A case-control study was performed by a retrospective chart review of infants with moderate or severe HIE admitted to a level IV regional perinatal center and who underwent whole-body cooling. Results A total of 14 (8.1%) of 171 infants with moderate or severe HIE who underwent whole-body cooling developed SFN during hospitalization. There were more females [71% (10/14)] and large-for-gestational age (LGA) infants [28% (4/14)] in the SFN group vs. 36% females (57/157) and 8% LGA infants (13/157) in the group without SFN (P-values of 0.009 and 0.015, respectively). The mean lowest platelet count was lower 108 ± 55 109/L vs. 146 ± 62 109/L and the mean highest calcium level was higher 11.3 ± 2.5 vs. 10.6 ± 0.8 mg/dL in infants with SFN vs. infants without SFN, respectively (P-values of 0.0078 and 0.006, respectively). Distribution of skin lesions followed distinctive patterns representing the areas with direct contact with the cooling blanket. One infant developed severe, life-threatening hypercalcemia that required aggressive management, including diuretics, corticosteroids and bisphosphonates. Conclusion Although SFN is a rare complication of therapeutic hypothermia, it can be a life-threatening condition if complicated by severe hypercalcemia. Infants who undergo therapeutic hypothermia for HIE need regular skin examinations to evaluate for SFN. If SFN is identified, monitoring of serum calcium levels to prevent life-threatening hypercalcemia is recommended.

Systemic effects of whole-body cooling to 35, 33 and 30 deg c in a piglet model of perinatal asphxyia

2011 ◽  
Vol 96 (Supplement 1) ◽  
pp. Fa13-Fa14
Author(s):  
S. Faulkner ◽  
M. Chandrasekaran ◽  
A. Kerenyi ◽  
D. Kelen ◽  
D. Price ◽  
...  
Keyword(s):  
Whole Body ◽  
Systemic Effects ◽  
Body Cooling ◽  
Whole Body Cooling

scholarly journals Therapeutic hypothermia in asphyxiated newborns: selective head cooling vs. whole body cooling — comparison of short term outcomes

2019 ◽  
Vol 90 (7) ◽  
pp. 403-410 ◽  
Author(s):  
Ewa Matylda Gulczynska ◽  
Janusz Gadzinowski ◽  
Marcin Kesiak ◽  
Barbara Sobolewska ◽  
Joanna Caputa ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Whole Body ◽  
Short Term ◽  
Head Cooling ◽  
Body Cooling ◽  
Whole Body Cooling

scholarly journals Edward Osmund Royle Reynolds CBE. 3 February 1933—24 April 2017

2019 ◽  
Vol 68 ◽  
pp. 333-351
Author(s):  
Rodney P. A. Rivers
Keyword(s):  
Perinatal Asphyxia ◽  
Perinatal Period ◽  
First Century ◽  
Whole Body ◽  
Resonance Spectroscopy ◽  
Scientific Medicine ◽  
The United Kingdom ◽  
New Ideas ◽  
Body Cooling ◽  
Whole Body Cooling

Edward Osmund Royle Reynolds was the founding father of neonatal medicine in the United Kingdom and a major leader in the field worldwide; he was a key advisor to government for a decade. He was one of the first paediatricians to specialize in the care of the newborn. He brought to the field a new emphasis on scientific medicine and intellectual rigour with an adventurous investigative and collaborative spirit. Known as Os by his colleagues, he inspired a team of clinicians and scientists who contributed to major advances in our understanding of lung disease in preterm infants and of neurological insults arising in the perinatal period that have contributed to the markedly improved survival and developmental outcomes observed in the twenty-first century compared with those of the 1950s and 1960s. The whole-body cooling, now widely utilized in the management of perinatal asphyxia, owes its introduction to the ground-breaking research utilizing magnetic resonance spectroscopy in animal and newborn studies initiated by Os. His enthusiasm for new ideas was often in evidence as was the breadth of his interests, knowledge and support. His wider influence is his legacy of the reports to government in which he was involved and is seen today in the National Neonatal Audit Programme run by the Royal College of Paediatrics and Child Health since 2006.

Local skin injury as a complication of whole body cooling for perinatal asphyxia

2012 ◽  
Vol 98 (2) ◽  
pp. F150-F151 ◽  
Author(s):  
Gamze Demirel ◽  
Istemi Han Celik ◽  
Fuat Emre Canpolat ◽  
Serife Suna Oguz ◽  
Omer Erdeve ◽  
...  
Keyword(s):  
Perinatal Asphyxia ◽  
Whole Body ◽  
Skin Injury ◽  
Local Skin ◽  
Body Cooling ◽  
Whole Body Cooling

scholarly journals A Neonate with Subcutaneous Fat Necrosis after Passive Cooling: Does Polycythemia Have an Effect?

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Erhan Calisici ◽  
Mehmet Yekta Oncel ◽  
Halil Degirmencioglu ◽  
Gonca Sandal ◽  
Fuat Emre Canpolat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Perinatal Asphyxia ◽  
Subcutaneous Fat ◽  
Whole Body ◽  
Passive Cooling ◽  
Inflammatory Disorder ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Body Cooling ◽  
Whole Body Cooling

Subcutaneous fat necrosis (SCFN) is an inflammatory disorder of adipose tissue. The main risk factors for the development of SCFN are perinatal asphyxia and hypothermia. Presented here is a case of a newborn who developed SCFN in association with polycythemia and hypocalcemia following treatment by passive cooling. Neonates who undergo passive or whole body cooling therapy should be closely monitored for any signs of SCFN.

Whole-body cooling after perinatal asphyxia: a pilot study in term neonates

2007 ◽  
Vol 45 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Thierry Debillon ◽  
Patrick Daoud ◽  
Philippe Durand ◽  
Sylvain Cantagrel ◽  
Philippe Jouvet ◽  
...  
Keyword(s):  
Pilot Study ◽  
Perinatal Asphyxia ◽  
Whole Body ◽  
Term Neonates ◽  
Body Cooling ◽  
Whole Body Cooling

Whole-body cooling after perinatal asphyxia: a pilot study in term neonates

2002 ◽  
Vol 45 (01) ◽  
Author(s):  
Thierry Debillon ◽  
Patrick Daoud ◽  
Philippe Durand ◽  
Sylvain Cantagrel ◽  
Philippe Jouvet ◽  
...  
Keyword(s):  
Pilot Study ◽  
Perinatal Asphyxia ◽  
Whole Body ◽  
Term Neonates ◽  
Body Cooling ◽  
Whole Body Cooling
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