scholarly journals Secretomic analysis of large cell lung cancer cell lines using two-dimensional gel electrophoresis coupled to mass spectrometry

2012 ◽  
Vol 50 (3) ◽  
pp. 368-374 ◽  
Author(s):  
Zahra Yousefi ◽  
Jamal Sarvari ◽  
Kazuyuki Nakamura ◽  
Yasuhiro Kuramitsu ◽  
Abbas Ghaderi ◽  
...  
2019 ◽  
Vol 10 (5) ◽  
pp. 1111-1128
Author(s):  
Zhenkun Liu ◽  
Song Xu ◽  
Lu Li ◽  
Xiaorong Zhong ◽  
Chun Chen ◽  
...  

2020 ◽  
Vol 16 (10) ◽  
pp. 1111-1119 ◽  
Author(s):  
Benjamin Ruprecht ◽  
Julie Di Bernardo ◽  
Zhao Wang ◽  
Xuan Mo ◽  
Oleg Ursu ◽  
...  

2017 ◽  
Vol 6 (2) ◽  
pp. 7
Author(s):  
Angela Hong ◽  
Xiaoying Zhang ◽  
Xiao Mei Zhang ◽  
Barbara Rose

Background:We have previously shown that stable transfection of the human papillomavirus (HPV) E6*I oncogene can sensitize two HPV negative oropharyngeal cancer (OSCC) cell lines to radiation. In the current study, we extended our work on OSCC to determine whether the HPV E6 oncogene can enhance the radiosensitivity of non-OSCC cell lines.Methods:Three non-OSCC cell lines (melanoma, colorectal adenocarcinoma and large cell lung cancer) were stably transfection with the HPV E6 oncogene (E6 total, E6*I and E6*II) and treated with different doses of radiation. Clonogenic assays were used to measure the radiation survival.Results:Following transfection, there was a reduction in the survival of the melanoma cell line after 2 Gy (SF2) from 0.401 (untransfected) to 0.219 (Melanoma-E6 total). This reduction was not evident at higher doses of radiation. There was no significant change in the SF2 of melanoma-E6*I (0.303) and melanoma-E6*II (0.414). The SF2 colorectal adenocarcinoma and large cell lung cancer cell lines did not change significantly after transfection.Conclusions: The radiosensitizing effect of HPV E6 oncogene is cell line specific. We found no clear evidence of a radiosensitising effect of E6 in these three non-OSCC cancer cell lines.


2020 ◽  
Vol 16 (10) ◽  
pp. 1149-1149
Author(s):  
Benjamin Ruprecht ◽  
Julie Di Bernardo ◽  
Zhao Wang ◽  
Xuan Mo ◽  
Oleg Ursu ◽  
...  

PROTEOMICS ◽  
2016 ◽  
Vol 16 (21) ◽  
pp. 2801-2814 ◽  
Author(s):  
Konstanze Bosse ◽  
Silvia Haneder ◽  
Christian Arlt ◽  
Christian H. Ihling ◽  
Thomas Seufferlein ◽  
...  

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