scholarly journals Atrial fibrillation ablation: Limitations of pulmonary vein ablation catheter technology

2014 ◽  
Vol 21 (5) ◽  
pp. 583-583
Author(s):  
Maciej Wójcik ◽  
Alexander Berkowitsch ◽  
Malte Kuniss ◽  
Thomas Neumann
Keyword(s):  
Atrial Fibrillation ◽  
Pulmonary Vein ◽  
Atrial Fibrillation Ablation ◽  
Ablation Catheter ◽  
Pulmonary Vein Ablation ◽  
Catheter Technology ◽  
Pulmonary Vein Ablation Catheter

scholarly journals Intracardiac Fibrinolysis and Endothelium Activation Related to Atrial Fibrillation Ablation with Different Techniques

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Orsolya Hajas ◽  
Zsuzsa Bagoly ◽  
Noémi K Tóth ◽  
Réka Urbancsek ◽  
Alexandra Kiss ◽  
...  
Keyword(s):  
Pulmonary Vein ◽  
Endothelial Activation ◽  
Ablation Catheter ◽  
Antithrombotic Treatment ◽  
Pulmonary Vein Ablation ◽  
Fviii Activity ◽  
Before And After ◽  
Pai 1 ◽  
D Dimer ◽  
Pulmonary Vein Ablation Catheter

Objective. The effect of pulmonary vein isolation (PVI) on fibrinolytic and endothelial activation with currently applied periprocedural anticoagulation has not been explored. We measured markers of fibrinolysis and endothelium activation before and after PVI with the second-generation cryoballoon (Cryo), pulmonary vein ablation catheter (PVAC-Gold), and irrigated radiofrequency (IRF). Methods. Markers of fibrinolysis and endothelium activation in left atrial (LA) blood samples were measured in 31 patients before and after PVI (Cryo:10, PVAC-Gold: 7, IRF: 14). Periprocedural anticoagulation included uninterrupted vitamin K antagonist and iv heparin (ACT≥300 sec) during LA dwelling. Results. Levels of D-dimer (median; interquartile range, mgFEU/L) increased with all techniques (PVAC: 0.34; 0.24–0.50 versus 0.70; 0.61–1.31; p=0.0313, Cryo: 0.33; 0.28–0.49 versus 0.79; 0.65–0.93; p=0.0078; IRF 0.33; 0.21–0.44 versus 0.83; 0.56–1.21; p=0.0001). PAP complex level (ng/ml) increased after Cryo (247.3, 199.9–331.6 versus 270.9, 227.9–346.7; p=0.0020) and IRF (265.3; 202.0–800.1 versus 325.6, 250.2–701.9; p=0.0166), but not after PVAC (p=0.2969). PAI-1 activity (%) decreased with the PVAC (1.931; 0.508–3.859 versus 0.735, 0.240–2.707; p=0.0313) and Cryo (0.361; 0.080–1.575 versus 0.378; 0.111–0.915; p=0.0313). A similar trend was observed with IRF (p=0.0676). Both VWF antigen levels and FVIII activity increased after PVI with all the 3 techniques. The levels of soluble VCAM-1 (ng/ml) did not change after PVAC procedures, but increased after Cryo (542, 6; 428.5–753.1 versus 619.2; 499.8–799.0; p=0.0005) and IRF (679.3; 505.0–744.7 versus 770.9; 631.9–894.0; p<0.0001). Conclusion. PVI with contemporary ablation techniques and periprocedural antithrombotic treatment induces coagulation and endothelium activation of similar magnitude with different ablation methods.

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