scholarly journals Atherosclerosis burden and coronary artery lesion complexity in acute coronary syndrome patients

2012 ◽  
Vol 19 (3) ◽  
pp. 295-300 ◽  
Author(s):  
Levent Korkmaz ◽  
Adem Adar ◽  
Ayca Ata Korkmaz ◽  
Hakan Erkan ◽  
Mustafa Tarik Agac ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Coronary Artery Lesion ◽  
Coronary Syndrome

Abstract 4008: PSGL-1-Expressing CD4 T Cells are Enriched in Culprit Coronary Artery Lesion of Acute Coronary Syndrome

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Keiko Gomita ◽  
Kayoko Sato ◽  
Kazutaka Kitamura ◽  
Nobuhisa Hagiwara
Keyword(s):  
T Cells ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Adhesion Molecules ◽  
Peripheral Blood ◽  
Cd4 T Cells ◽  
Coronary Artery Lesion ◽  
Plaque Instability ◽  
Coronary Syndrome

Background: Recently, several evidences on the crucial role of adhesion molecules in the development of atherosclerosis and plaque instability have been reported. While expression of VCAM-1, ICAM-1 and L-selectin has been consistently observed in atherosclerotic plaques it is still uncertain how adhesion molecules on T cells contribute to the incidence of acute coronary syndrome (ACS). In this study, we examined whether adhesion molecules on T cells in ACS have a significant role in the plaque stability and prone to cause ACS. Methods and Results: Fresh CD4 T cells were isolated from the peripheral blood of 76 ACS patients (AMI=35, UAP=41) and 74 age-matched controls (NC). CD69, an activation marker of T cells, was strongly expressed on CD4 T cells from ACS than from NC by FACS (P<0.0001). CD4 T cells from ACS highly expressed p-selectin glycoprotein ligand-1 (PSGL-1) and integrin β (CD18), but not L-selectin by FACS (P < 0.03, P < 0.01, n.s., respectively). Soluble PSGL-1 (sPSGL-1) levels in plasma were lower in ACS patients than in NC (P=0.0001), which correlated negatively with the PSGL-1 expression on CD4 T cells (R=0.405, P<0.02). We further investigated the thrombus-aspirating device samples (n=14) and fresh CD4 T cells derived from both the coronary artery and peripheral blood from the each same patient with ACS. CD4 T cells from the coronary artery strongly expressed PSGL-1 (P<0.002), but not integrin β (CD18) and L-selectin by FACS. Finally, PSGL-1 was expressed on T cells, but not on CD68 positive macrophage, MPO positive neutrophil, or CD41 positive platelets in the thrombus-aspirating device samples. Conclusions: From these results, we demonstrated that PSGL-1-expressing CD4 T cells are enriched in the culprit coronary artery lesion of ACS, contributing to the acceleration of plaque instability and occurrence of ACS.

scholarly journals CORRELATION BETWEEN CORONARY ARTERY LESION SEVERITY AND LONG-TERM CLINICAL OUTCOMES IN CHINESE HAN OCTOGENARIANS WITH ACUTE CORONARY SYNDROME

Heart ◽  
2012 ◽  
Vol 98 (Suppl 2) ◽  
pp. E191.1-E191
Author(s):  
Fu Zhenhong ◽  
Chen Yundai ◽  
Dong Wei ◽  
Chen Lian ◽  
Gai Luyue ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Clinical Outcomes ◽  
Coronary Artery Lesion ◽  
Chinese Han ◽  
Coronary Syndrome ◽  
Lesion Severity

scholarly journals Nghiên cứu mối liên quan giữa nồng độ ima (Ischemia modified albumin) và mức độ tổn thương động mạch vành ở bệnh nhân hội chứng vành cấp

2020 ◽  
Author(s):  
Quang Tuấn Phạm
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Coronary Artery Lesion ◽  
Gensini Score ◽  
Coronary Artery Lesions ◽  
Coronary Syndrome ◽  
Coronary Lesions ◽  
Universal Definition ◽  
Definition Of ◽  
Artery Branch

RESEARCH THE CORRELATION BETWEEN IMA CONCENTRATION AND DEGREE OF CORONARY ARTERY LESIONS IN PATIENTS WITH ACUTE CORONARY SYNDROME Introduction: Coronary artery lesions were the main cause of ACS, the character of coronary artery lesion and how is IMA concentrations correlated with degree of coronary artery lesion in acute coronary syndrome? Objective: Survey character of coronary artery lesions in patients with acute coronary syndrome through the results of angiography and correlation between the concentration of IMA and degree of coronary artery lesions in patients with acute coronary syndrome. Subject and Method: 130 patients at the Cardiology Center-Hue Central Hospital are diagnosed acute coronary syndrome according to the Fourth universal definition of myocardial infarction 2018. In which 103 patients were taken angiography and evaluated the coronary artery lesions follow GENSINI scale. Result: Research conducted on 130 patients, including 85 males and 45 females with the proportion of male: female is 1.89, average age: 65.7 ± 12.3years old. There are 91.3% of patients with coronary artery lesions higher than coronary artery non lesions (p <0.001). Injury of one branch accounted for 35,9%, two branch accounted for 34.0% and three branch injuries accounted for 21.4%.. There are 79.6% in LAD injury and 58.3% in RCA, accounting for 41.7% in LCx. The lesions stenosis that more than 75% is accounted for the highest percentage 70.59%. GENSINI score average is 27.80 ± 25.92 and median score is 21 points. There is no correlation between the concentration of IMA and the branching coronary lesions with r = - 0,046, p > 0.05. There is no correlation between the concentration of IMA and GENSINI scores with r = - 0,064, p> 0,05. Conclusions: LAD lesions accounted for the highest percentage, lesions more than one coronary artery branch also high percentage and severe coronary stenosis is highest proportion in acute coronary syndrome. There is no correlation between the IMA concentration and the number of branching coronary lesions, as well as GENSINI scores. Key words: IMA, Coronay artery lesions, ACS.

scholarly journals The relation between intensity and complexity of coronary artery lesion and oxidative stress in patients with acute coronary syndrome

2015 ◽  
Vol 15 (10) ◽  
pp. 795-800 ◽  
Author(s):  
Turhan Turan ◽  
Umit Mentese ◽  
Mustafa Tarik Agac ◽  
Ali Riza Akyuz ◽  
Selim Kul ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Coronary Artery Lesion ◽  
Coronary Syndrome ◽  
And Oxidative Stress
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