scholarly journals The relation between intensity and complexity of coronary artery lesion and oxidative stress in patients with acute coronary syndrome

2015 ◽  
Vol 15 (10) ◽  
pp. 795-800 ◽  
Author(s):  
Turhan Turan ◽  
Umit Mentese ◽  
Mustafa Tarik Agac ◽  
Ali Riza Akyuz ◽  
Selim Kul ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Coronary Artery Lesion ◽  
Coronary Syndrome ◽  
And Oxidative Stress

scholarly journals Atherosclerosis burden and coronary artery lesion complexity in acute coronary syndrome patients

2012 ◽  
Vol 19 (3) ◽  
pp. 295-300 ◽  
Author(s):  
Levent Korkmaz ◽  
Adem Adar ◽  
Ayca Ata Korkmaz ◽  
Hakan Erkan ◽  
Mustafa Tarik Agac ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Coronary Artery Lesion ◽  
Coronary Syndrome

Abstract 4008: PSGL-1-Expressing CD4 T Cells are Enriched in Culprit Coronary Artery Lesion of Acute Coronary Syndrome

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Keiko Gomita ◽  
Kayoko Sato ◽  
Kazutaka Kitamura ◽  
Nobuhisa Hagiwara
Keyword(s):  
T Cells ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Adhesion Molecules ◽  
Peripheral Blood ◽  
Cd4 T Cells ◽  
Coronary Artery Lesion ◽  
Plaque Instability ◽  
Coronary Syndrome

Background: Recently, several evidences on the crucial role of adhesion molecules in the development of atherosclerosis and plaque instability have been reported. While expression of VCAM-1, ICAM-1 and L-selectin has been consistently observed in atherosclerotic plaques it is still uncertain how adhesion molecules on T cells contribute to the incidence of acute coronary syndrome (ACS). In this study, we examined whether adhesion molecules on T cells in ACS have a significant role in the plaque stability and prone to cause ACS. Methods and Results: Fresh CD4 T cells were isolated from the peripheral blood of 76 ACS patients (AMI=35, UAP=41) and 74 age-matched controls (NC). CD69, an activation marker of T cells, was strongly expressed on CD4 T cells from ACS than from NC by FACS (P<0.0001). CD4 T cells from ACS highly expressed p-selectin glycoprotein ligand-1 (PSGL-1) and integrin β (CD18), but not L-selectin by FACS (P < 0.03, P < 0.01, n.s., respectively). Soluble PSGL-1 (sPSGL-1) levels in plasma were lower in ACS patients than in NC (P=0.0001), which correlated negatively with the PSGL-1 expression on CD4 T cells (R=0.405, P<0.02). We further investigated the thrombus-aspirating device samples (n=14) and fresh CD4 T cells derived from both the coronary artery and peripheral blood from the each same patient with ACS. CD4 T cells from the coronary artery strongly expressed PSGL-1 (P<0.002), but not integrin β (CD18) and L-selectin by FACS. Finally, PSGL-1 was expressed on T cells, but not on CD68 positive macrophage, MPO positive neutrophil, or CD41 positive platelets in the thrombus-aspirating device samples. Conclusions: From these results, we demonstrated that PSGL-1-expressing CD4 T cells are enriched in the culprit coronary artery lesion of ACS, contributing to the acceleration of plaque instability and occurrence of ACS.

Reduced clot permeability and susceptibility to lysis in patients with acute coronary syndrome: Effects of inflammation and oxidative stress

2008 ◽  
Vol 196 (2) ◽  
pp. 551-557 ◽  
Author(s):  
Anetta Undas ◽  
Konstanty Szułdrzynski ◽  
Ewa Stepien ◽  
Jarosław Zalewski ◽  
Jacek Godlewski ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Coronary Syndrome ◽  
Coronary Syndrome ◽  
And Oxidative Stress

scholarly journals CORRELATION BETWEEN CORONARY ARTERY LESION SEVERITY AND LONG-TERM CLINICAL OUTCOMES IN CHINESE HAN OCTOGENARIANS WITH ACUTE CORONARY SYNDROME

Heart ◽  
2012 ◽  
Vol 98 (Suppl 2) ◽  
pp. E191.1-E191
Author(s):  
Fu Zhenhong ◽  
Chen Yundai ◽  
Dong Wei ◽  
Chen Lian ◽  
Gai Luyue ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Clinical Outcomes ◽  
Coronary Artery Lesion ◽  
Chinese Han ◽  
Coronary Syndrome ◽  
Lesion Severity

scholarly journals Biomarkers of Inflammation and Oxidative stress in the Prediction and Management of Acute Coronary Syndrome

2021 ◽  
Vol 3 ◽  
Author(s):  
Udaya Ralapanawa ◽  
Sivakanesan R
Keyword(s):  
Oxidative Stress ◽  
Acute Coronary Syndrome ◽  
Cardiac Troponin ◽  
Plaque Rupture ◽  
Myocardial Necrosis ◽  
Serum Markers ◽  
Diagnostic Challenge ◽  
Coronary Syndrome ◽  
Markers Of Inflammation ◽  
And Oxidative Stress

The assessment of patients presenting with chest pain or symptoms indicative of cardiac ischemia remains a diagnostic challenge. Many types of research have focused on the search for ideal biological markers for the rapid detection of cardiac cell injuries. Markers of inflammation and oxidative stress are the way forward. At present, the biomarker most widely used for diagnosing acute coronary syndrome is cardiac troponin though it has some limitations. Apart from cardiac troponin, several other biomarkers, especially inflammation and oxidative stress markers in acute coronary syndrome, have been investigated. However, most of them still require validation in further studies. As markers of inflammation and oxidative stress address a particular aspect of the pathophysiology of acute coronary syndrome, these biomarkers may provide unique information to the managing clinician separate from that of markers of myocyte necrosis.  Serum markers of inflammation and oxidative stress appear before cardiac necrosis markers and are valuable targets for early and timely diagnosis of an acute cardiac event. Using these markers in combination with biomarkers of plaque formation, unstable plaque development, plaque rupture, thrombosis, and myocardial necrosis (multimarker approach) could increase their diagnostic and prognostic value.

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