scholarly journals Potentiometric detection of low-levels of sulfamethazine in milk and pharmaceutical formulations using novel plastic membrane sensors

2018 ◽  
Vol 9 (1) ◽  
pp. 17-26
Author(s):  
Saad S. M. Hassan ◽  
Ayman H. Kamel ◽  
Nada H. A. Elbehery
Keyword(s):  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Biological Tissues ◽  
Potentiometric Sensors ◽  
Injection System ◽  
Aliquat 336 ◽  
Milk Samples ◽  
Plastic Membrane ◽  
Flow Injection System ◽  
Singly Charged

Novel potentiometric sensors for selective screening of sulfamethazine (SMZ) in pharmaceutical preparations and milk samples are reported. The sensor membranes were made from PVC matrix doped with magnesium(II)-, manganese(II)- and dichlorotin (IV)-phthalocyanines as ionophores and aliquat-336 and nitron/SMZ ion-pair complex as ion exchangers. These sensors revealed fast, stable and near-Nernstian anionic response for the singly charged sulfamethazine anion over the concentration range 10-2 - 10-5 M. The sensors exhibited good selectivity towards SMZ over most known anions, excipients and diluents commonly added in drug preparations. Validation of the proposed methods was demonstrated via evaluating the detection limit, linear response range, accuracy, precision (within-day repeatability) and between-day-variability. The sensors are easily interfaced with a double channel flow injection system and used for continuous monitoring of SMZ in drug formulations, spiked milk samples and biological tissues. The method offers the advantages of design simplicity, results accuracy, and automation feasibility.

scholarly journals A novel online coupling of ion selective electrode with the flow injection system for the determination of vitamin B1

2016 ◽  
Vol 13 (2) ◽  
pp. 458-469
Author(s):  
Baghdad Science Journal
Keyword(s):  
Flow Injection ◽  
Dynamic Range ◽  
Limit Of Detection ◽  
Vitamin B1 ◽  
Pharmaceutical Formulations ◽  
Ion Selective Electrode ◽  
Injection System ◽  
Selective Electrode ◽  
Flow Injection System

A simple, fast, selective of a new flow injection analysis method coupled with potentiometric detection was used to determine vitamin B1 in pharmaceutical formulations via the prepared new selective membranes. Two electrodes were constructed for the determination of vitamin B1 based on the ion-pair vitamin B1-phosphotungestic acid (B1-PTA) in a poly (vinyl chloride) supported with a plasticized di-butyl phthalate (DBPH) and di-butyl phosphate (DBP). Applications of these ion selective electrodes for the determination of vitamin B1 in the pharmaceutical preparations for batch and flow injection systems were described. The ion selective membrane exhibited a near-Nernstian slope values 56.88 and 58.53 mV / decade, with the linear dynamic range of vitamin B1 was 5 x 10-5- 1 x 10-2 and 1 x 10-4-1 x 10-2 mol.L-1, in batch and FIA, respectively. The limit of detection was 3.5 x 10-5 and 9.5 x 10-5 mol.L-1, with the percentage linearity 98.85 and 95.22 in batch and FIA, respectively. The suggested ion selective electrode has been utilized perfection in the determination of vitamin B1 in pharmaceutical formulations using batch and flow injection system, respectively.

scholarly journals Determination of phenobarbital in human urine and serum usingflow injection chemiluminescence

2012 ◽  
Vol 58 (1) ◽  
pp. 88-94
Author(s):  
K. Li ◽  
L.Z. Nu ◽  
K.L. Khe ◽  
K.H. Song
Keyword(s):  
Human Urine ◽  
Pharmaceutical Preparations ◽  
Injection System ◽  
Chemiluminescence Method ◽  
Chemiluminescence Intensity ◽  
Complete Determination ◽  
Flow Injection System ◽  
Human Urine And Serum ◽  
Urine And Serum

A sensitive chemiluminescence method, based on the enhancive effect of phenobarbital on the chemiluminescence reaction between luminol and dissolved oxygen in a flow injection system, was proposed for the determination of phenobarbital. The chemiluminescence intensity responded to the concentration of phenobarbital linearly ranging from 0.05 to 10 ng⋅ml-1 with the detection limit of 0.02 ng⋅ml-1 (3σ). At a flow rate of 2.0 ml⋅min-1, a complete determination of phenobarbital, including sampling and washing, could be accomplished in 0.5 min, offering the sampling efficiency of 120 h-1 accordingly. The method was applied successfully in an assay of PB for pharmaceutical preparations, human urine and serum without any pretreatment with recovery from 95.7 to 106.7% and RSDs of less than 3.0%.

Electrospun polystyrene/Aliquat 336 for preconcentration and determination of thiocyanate in flow analysis

2017 ◽  
Vol 1 (1) ◽  
pp. 100-110
Author(s):  
Yukie O’Bryan ◽  
Yen B. Truong ◽  
Robert W. Cattrall ◽  
Illias L. Kyratzis ◽  
Spas D. Kolev
Keyword(s):  
Sampling Rate ◽  
Packed Column ◽  
Flow Analysis ◽  
Glass Tube ◽  
Injection System ◽  
Aliquat 336 ◽  
Linear Calibration ◽  
Flow Injection System ◽  
Analysis System

Abstract A new extracting polymer wool was prepared from polystyrene (PS) and the commercial extractant Aliquat 336 by electrospinning and its potential as a packing material for an online preconcentration column in an automated flow injection system was investigated for the determination of thiocyanate (SCN−). The formation of the wool fibres was confirmed by scanning electron microscopy (SEM). The polymer wool was inserted into a glass tube to prepare a column. SCN− solutions of different volumes (2-10 mL) were passed through the fibre-packed column where SCN− was extracted by the fibres. The columnwas then eluted with a small volume of 1MNaNO3 solution. The eluatewas mixed with an iron(III) solution and the resulting coloured complex (FeSCN2+) was detected colorimetrically. The system successfully achieved 21-fold preconcentration of SCN−. A linear calibration curve was obtained in the range from 0.02 to 1.0 mg L−1 SCN− with a sampling rate of 9 h−1. To the authors’ best knowledge this is the first time electrospun fibres containing a liquid extractant have been used for preconcentration in a flow analysis system.

Screening and determination of sulphonamide residues in bovine milk samples using a flow injection system

2015 ◽  
Vol 166 ◽  
pp. 309-315 ◽  
Author(s):  
Flávio Cesar Bedatty Fernandes ◽  
Aline Santana Silva ◽  
José Luiz Rufino ◽  
Helena Redigolo Pezza ◽  
Leonardo Pezza
Keyword(s):  
Flow Injection ◽  
Bovine Milk ◽  
Injection System ◽  
Milk Samples ◽  
Flow Injection System

Colorimetric Determination of Amoxicillin in Pure and some Pharmaceutical Formulations Via Reaction with Potassium Permanganate as Oxidant Reagent

2019 ◽  
Vol 10 (02) ◽  
Author(s):  
Abbas Shebeeb Al-kadumi ◽  
Sahar Rihan Fadhel ◽  
Mohammed Abdullah Ahmed ◽  
Luma Amer Musa
Keyword(s):  
Potassium Permanganate ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Atomic Emission ◽  
Basic Medium ◽  
Photometric Method ◽  
Colorimetric Determination ◽  
Spectrophotometric Methods ◽  
Label Claim

We proposed two simple, rapid, and convenient spectrophotometric methods are described for the determination of Amoxicillin in bulk and its pharmaceutical preparations. They are based on the measurement of the flame atomic emission of potassium ion (in first method) and colorimetric determination of the green colored solution for manganite ion at 610 nm formed after reaction of Amoxicillin with potassium permanganate as oxidant agent (in the second method) in basic medium. The working conditions of the methods were investigated and optimized. Beer's law plot showed a good correlation in the concentration range of 5-45 μg/ml. The detection limits and relative standared deviations were (2.573, 2.814 μg/ml) (2.137, 2.498) for the flame emission photometric method and (1.844, 2.016 μg/ml) (1.645,1.932) for colorimetric methods for capsules and suspensions respectively. The methods were successfully applied to the determination of Amoxicillin in capsules and suspensions, and the obtained results were in good agreement with the label claim. No interference was observed from the commonly encountered additives and expectancies.

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