scholarly journals Effect of aminoacids on the fungicidal activity of quaternary ammonium salts

2013 ◽  
Vol 45 (2) ◽  
pp. 207-217
Author(s):  
Jerzy Piątkowski ◽  
Michał Świątek

Amphipatic compounds exhibit an antimicrobial action both on bacteria and fungi. It is caused by a penetrative property of hydrophobic carbon chain of the compuound into a plasma membrane as well as by additional interaction of membrane elements and a hydrophilic amphipathic compound head. Bactericidal and fungicidal activity of this compound strongly depends on chemical environmental factors. In general, microorganisms are not as sensitive in a full medium as in a minimal one and the level of sensitivity rises when the amphipatic compounds are presend in destilled water. Similarly, the sensitivity is stronger in fluid than on solid medium. Our researches revealed however that some aminoacids, although they are complex organic compounds, increase the microbial sensitivity to some tested compound. This efect depends on a microorganism and on a kind of compound. The highest hipersensitivity has been observed against yeast-like fungi when arginine was a cooperating aminoacid. The effect concerns <em><em>Trichosporon</em> but not <em>E.coli</em>, not occurs in relation to SDS, quaternary ammonium salt IA, and bisammonium salts. Certainly the effect exhibit QAS, which have simple composition of hydrophilic „head” consisting only of methyl group, attaching to alkilic chain possessing keton group, build of 14 or 16 carbon atoms.

1999 ◽  
Vol 4 (1) ◽  
pp. 41-44 ◽  
Author(s):  
SHIN OHTA ◽  
MASAHIRO MAKINO ◽  
KATSUHIRO NAGAI ◽  
HIROSHI ZENDA

Author(s):  
Rocky Barney ◽  
Tony Stark ◽  
Dru Delaet

Quaternary ammonium salts (otherwise known as quats) are commonly used active ingredients in biocide formulations used in the anti-microbial industry. Although quats have been established to be effective biocides, there are few studies investigating the maximization of biocidal efficacy in multiple component formulations using various carbon chain lengths. Reported here is the synthesis based on the Sn2 reaction of tertiary amines with alkyl bromide. Surfactant studies of the single and dual component systems were conducted, and the evaluation is explored.


2013 ◽  
Vol 83 (9) ◽  
pp. 1698-1702
Author(s):  
D. A. Vasilevskii ◽  
V. G. Petushok ◽  
G. V. Kalechits ◽  
R. A. Zheldakova ◽  
V. K. Ol’khovik

Author(s):  
Tomasz K. Olszewski ◽  
Anna Brol

An effective protocol for quaternization of simple 1-aminoalkylphosphonic acids under basic conditions and using Me2SO4 as convenient alkylating agent is reported. In the course of reaction phosphonic acid quaternary ammonium...


Molecules ◽  
2019 ◽  
Vol 24 (13) ◽  
pp. 2424 ◽  
Author(s):  
Tăbăcaru ◽  
Botezatu ◽  
Horincar ◽  
Furdui ◽  
Dinică

A family of fifteen quaternary ammonium salts (QAs), bearing the 1,2-bis(4-pyridyl)ethane core, were obtained using for the first time two different green methods, such as microwave (MW) and ultrasounds (US) irradiation, with very good yields and in much shorter times compared to the classical method, and an assay on their antimicrobial action against Escherichia coli (E. coli) was carried out. While 12 to 24 hours were required for complete alkylation of 1,2-bis(4-pyridyl)ethane by reactive halogenated derivatives in anhydrous solvent under reflux conditions, MW and US irradiation reduced the reaction time and the desired products were achieved in a few min. One of the aims of this study was to evaluate the antibacterial potential of the synthesized QAs against pathogenic bacteria, along with their impact on germination activity of wheat seeds (Triticum aestivum L.). The antibacterial activity of the QAs against Escherichia coli was explored by determining the minimum inhibitory concentration (MIC). The MIC values varied from 0.312 to 2.5 mg/mL, highlighting the lowest values attained for the derivatives containing methoxy, chlorine and benzofurane functional groups. The viability of aerobic bacteria was determined with the Tetrazolium/Formazan Test, a method that was found to be the best alternative approach with respect to the difuzimetric method. Seeds of Triticum aestivum L. were used for the evaluation of the germination indicators, such as seed germination (SG), the relative seed germination (RSG), the relative radicle growth (RRG), and the seed germination index (GI). The toxicity studies of QAs 1, 4 and 7, at two different concentrations, showed no inhibitory effect on seed germination.


1996 ◽  
Vol 32 (6) ◽  
pp. 331-334
Author(s):  
V. V. Turov ◽  
O. A. Zaporozhets ◽  
O. Yu. Nadzhafova ◽  
V. V. Sukhan

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