Application of Maximum Tolerable Wall Tension Index as an Indicator of Lung Injury following Acid Aspiration

10.5580/237e ◽  
1997 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Lung Injury ◽  
Wall Tension ◽  
Acid Aspiration ◽  
Tension Index

scholarly journals Effects of Positive End-expiratory Pressure Titration and Recruitment Maneuver on Lung Inflammation and Hyperinflation in Experimental Acid Aspiration–induced Lung Injury

2012 ◽  
Vol 117 (6) ◽  
pp. 1322-1334 ◽  
Author(s):  
Aline M. Ambrosio ◽  
Rubin Luo ◽  
Denise T. Fantoni ◽  
Claudia Gutierres ◽  
Qin Lu ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Lung Inflammation ◽  
Recruitment Maneuver ◽  
Alveolar Wall ◽  
Arterial Oxygenation ◽  
Positive End Expiratory Pressure ◽  
Acid Aspiration ◽  
Recruitment Maneuvers ◽  
Alveolar Area

Background In acute lung injury positive end-expiratory pressure (PEEP) and recruitment maneuver are proposed to optimize arterial oxygenation. The aim of the study was to evaluate the impact of such a strategy on lung histological inflammation and hyperinflation in pigs with acid aspiration-induced lung injury. Methods Forty-seven pigs were randomly allocated in seven groups: (1) controls spontaneously breathing; (2) without lung injury, PEEP 5 cm H2O; (3) without lung injury, PEEP titration; (4) without lung injury, PEEP titration + recruitment maneuver; (5) with lung injury, PEEP 5 cm H2O; (6) with lung injury, PEEP titration; and (7) with lung injury, PEEP titration + recruitment maneuver. Acute lung injury was induced by intratracheal instillation of hydrochloric acid. PEEP titration was performed by incremental and decremental PEEP from 5 to 20 cm H2O for optimizing arterial oxygenation. Three recruitment maneuvers (pressure of 40 cm H2O maintained for 20 s) were applied to the assigned groups at each PEEP level. Proportion of lung inflammation, hemorrhage, edema, and alveolar wall disruption were recorded on each histological field. Mean alveolar area was measured in the aerated lung regions. Results Acid aspiration increased mean alveolar area and produced alveolar wall disruption, lung edema, alveolar hemorrhage, and lung inflammation. PEEP titration significantly improved arterial oxygenation but simultaneously increased lung inflammation in juxta-diaphragmatic lung regions. Recruitment maneuver during PEEP titration did not induce additional increase in lung inflammation and alveolar hyperinflation. Conclusion In a porcine model of acid aspiration-induced lung injury, PEEP titration aimed at optimizing arterial oxygenation, substantially increased lung inflammation. Recruitment maneuvers further improved arterial oxygenation without additional effects on inflammation and hyperinflation.

scholarly journals Animal models of acute lung injury

2008 ◽  
Vol 295 (3) ◽  
pp. L379-L399 ◽  
Author(s):  
Gustavo Matute-Bello ◽  
Charles W. Frevert ◽  
Thomas R. Martin
Keyword(s):  
Risk Factors ◽  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury ◽  
Animal Studies ◽  
Ischemia Reperfusion ◽  
Alveolar Epithelium ◽  
Acid Aspiration ◽  
Advantages And Disadvantages ◽  
Clinical Risks

Acute lung injury in humans is characterized histopathologically by neutrophilic alveolitis, injury of the alveolar epithelium and endothelium, hyaline membrane formation, and microvascular thrombi. Different animal models of experimental lung injury have been used to investigate mechanisms of lung injury. Most are based on reproducing in animals known risk factors for ARDS, such as sepsis, lipid embolism secondary to bone fracture, acid aspiration, ischemia-reperfusion of pulmonary or distal vascular beds, and other clinical risks. However, none of these models fully reproduces the features of human lung injury. The goal of this review is to summarize the strengths and weaknesses of existing models of lung injury. We review the specific features of human ARDS that should be modeled in experimental lung injury and then discuss specific characteristics of animal species that may affect the pulmonary host response to noxious stimuli. We emphasize those models of lung injury that are based on reproducing risk factors for human ARDS in animals and discuss the advantages and disadvantages of each model and the extent to which each model reproduces human ARDS. The present review will help guide investigators in the design and interpretation of animal studies of acute lung injury.

scholarly journals Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury

10.3791/54700 ◽  
2017 ◽  
Author(s):  
Ravi Alluri ◽  
Hilliard L. Kutscher ◽  
Barbara A. Mullan ◽  
Bruce A. Davidson ◽  
Paul R. Knight
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Gastric Acid ◽  
Murine Model ◽  
Acid Aspiration

scholarly journals N-Acetyl-Heparin Attenuates Acute Lung Injury Caused by Acid Aspiration Mainly by Antagonizing Histones in Mice

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97074 ◽  
Author(s):  
Yanlin Zhang ◽  
Zanmei Zhao ◽  
Li Guan ◽  
Lijun Mao ◽  
Shuqiang Li ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Acid Aspiration

Reactive Oxygen Species Contribute to Oxygen-Related Lung Injury After Acid Aspiration

1998 ◽  
Vol 87 (1) ◽  
pp. 127-133 ◽  
Author(s):  
Nader Nader-Djalal ◽  
Paul R. Knight ◽  
Kuldip Thusu ◽  
Bruce A. Davidson ◽  
Bruce A. Holm ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Lung Injury ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Acid Aspiration
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