Inhibition of Human Prostate Cancer Growth and Prevention of Metastasis Development by Antiangiogenic Activities of Pigment Epithelium-Derived Factor

10.5580/15b4 ◽  
2007 ◽  
Vol 4 (1) ◽  
Keyword(s):  
Prostate Cancer ◽  
Pigment Epithelium ◽  
Human Prostate ◽  
Cancer Growth ◽  
Human Prostate Cancer ◽  
Pigment Epithelium Derived Factor ◽  
Metastasis Development

SONIC HEDGEHOG SIGNALING IN HUMAN PROSTATE AND BONE STROMAL CELLS: POTENTIAL ROLES IN LOCALIZED AND DISSEMINATED HUMAN PROSTATE CANCER GROWTH

2008 ◽  
Vol 179 (4S) ◽  
pp. 394-395
Author(s):  
Katsumi Shigemura ◽  
Haiyen E Zhau ◽  
Goudong Zhu ◽  
Masato Fujisawa ◽  
Akinobu Gotoh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Sonic Hedgehog ◽  
Stromal Cells ◽  
Hedgehog Signaling ◽  
Human Prostate ◽  
Cancer Growth ◽  
Human Prostate Cancer ◽  
Sonic Hedgehog Signaling

scholarly journals Centrosomal PKCβII and Pericentrin Are Critical for Human Prostate Cancer Growth and Angiogenesis

2008 ◽  
Vol 68 (16) ◽  
pp. 6831-6839 ◽  
Author(s):  
Jeewon Kim ◽  
Yoon-La Choi ◽  
Alice Vallentin ◽  
Ben S. Hunrichs ◽  
Marc K. Hellerstein ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Human Prostate ◽  
Cancer Growth ◽  
Human Prostate Cancer

Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: Comparison with silymarin and silibinin

2008 ◽  
Vol 123 (12) ◽  
pp. 2750-2758 ◽  
Author(s):  
Gagan Deep ◽  
Komal Raina ◽  
Rana P. Singh ◽  
Nicholas H. Oberlies ◽  
David J. Kroll ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Nude Mice ◽  
Human Prostate ◽  
Cancer Growth ◽  
Human Prostate Cancer ◽  
Athymic Nude Mice

535: Inhibiting Human Prostate Cancer Growth in Bone with an Acyl-Tyrosine Bisphosphonate Amide Derivative

2007 ◽  
Vol 177 (4S) ◽  
pp. 178-178
Author(s):  
Seongil Seo ◽  
Lajos Gera ◽  
Daqing Wu ◽  
Weiping Qian ◽  
Wen-Chin Huang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Human Prostate ◽  
Cancer Growth ◽  
Human Prostate Cancer ◽  
Amide Derivative

scholarly journals Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor

2006 ◽  
Vol 118 (11) ◽  
pp. 2721-2726 ◽  
Author(s):  
R. Daniel Bonfil ◽  
Aaron Sabbota ◽  
Sanaa Nabha ◽  
M. Margarida Bernardo ◽  
Zhong Dong ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Human Prostate ◽  
Cancer Growth ◽  
Human Prostate Cancer ◽  
Metastasis Model

436: Honokiol, an Attractive Natural Product, Inhibits Human Prostate Cancer Growth and Bone Metastasis

2006 ◽  
Vol 175 (4S) ◽  
pp. 141-142
Author(s):  
Katsumi Shigemura ◽  
Shian-Ying Sung ◽  
Jack Arbiser ◽  
Shi-Yong Sun ◽  
Majd Zayzafoon ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Natural Product ◽  
Human Prostate ◽  
Cancer Growth ◽  
Human Prostate Cancer

α-Pinene Inhibits Human Prostate Cancer Growth in a Mouse Xenograft Model

Chemotherapy ◽  
2017 ◽  
Vol 63 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Yunqi Zhao ◽  
Ran Chen ◽  
Yun Wang ◽  
Yixin Yang
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Line ◽  
Nude Mice ◽  
Xenograft Model ◽  
Human Prostate ◽  
Cancer Growth ◽  
Human Prostate Cancer ◽  
Subcutaneous Xenograft ◽  
Induced Apoptosis

Background: α-Pinene is one of the most widely found terpenoids in nature. Substantial evidence shows that α-pinene has cancer prevention properties. In this study, the PC-3 cell line was used to establish subcutaneous xenograft tumors in nude mice. Methods: Cytotoxicity was measured with the MTT assay, and apoptosis and cell cycle analyses were conducted using flow cytometry in vitro. The PC-3 cell line was used to establish subcutaneous xenograft tumors in nude mice. Results: We found that treatment with α-pinene significantly inhibited human prostate cancer cell growth and induced apoptosis and cell cycle arrest in the cell line-based model. Furthermore, tumor progression was inhibited more in mice treated with α-pinene than in control mice. We detected less Ki67 and proliferation cell nuclear antigen in paraffin sections from xenograft tumor specimens taken from α-pinene-treated mice than in those from the control group. Meanwhile, α-pinene treatment induced apoptosis in xenograft tumors as determined by the TUNEL assay. Conclusions: These data strongly suggest that α-pinene inhibits prostate cancer growth in a xenograft model and may be an effective therapeutic agent for prostate cancer treatment.

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