Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: Comparison with silymarin and silibinin

2008 ◽  
Vol 123 (12) ◽  
pp. 2750-2758 ◽  
Author(s):  
Gagan Deep ◽  
Komal Raina ◽  
Rana P. Singh ◽  
Nicholas H. Oberlies ◽  
David J. Kroll ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Nude Mice ◽  
Human Prostate ◽  
Cancer Growth ◽  
Human Prostate Cancer ◽  
Athymic Nude Mice

Development of skeletal metastasis by human prostate cancer in athymic nude mice

1988 ◽  
Vol 6 (5) ◽  
pp. 401-409 ◽  
Author(s):  
Daniel H. Shevrin ◽  
Subhash C. Kukreja ◽  
Luna Ghosh ◽  
Thomas E. Lad
Keyword(s):  
Prostate Cancer ◽  
Nude Mice ◽  
Skeletal Metastasis ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Athymic Nude Mice

α-Pinene Inhibits Human Prostate Cancer Growth in a Mouse Xenograft Model

Chemotherapy ◽  
2017 ◽  
Vol 63 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Yunqi Zhao ◽  
Ran Chen ◽  
Yun Wang ◽  
Yixin Yang
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Line ◽  
Nude Mice ◽  
Xenograft Model ◽  
Human Prostate ◽  
Cancer Growth ◽  
Human Prostate Cancer ◽  
Subcutaneous Xenograft ◽  
Induced Apoptosis

Background: α-Pinene is one of the most widely found terpenoids in nature. Substantial evidence shows that α-pinene has cancer prevention properties. In this study, the PC-3 cell line was used to establish subcutaneous xenograft tumors in nude mice. Methods: Cytotoxicity was measured with the MTT assay, and apoptosis and cell cycle analyses were conducted using flow cytometry in vitro. The PC-3 cell line was used to establish subcutaneous xenograft tumors in nude mice. Results: We found that treatment with α-pinene significantly inhibited human prostate cancer cell growth and induced apoptosis and cell cycle arrest in the cell line-based model. Furthermore, tumor progression was inhibited more in mice treated with α-pinene than in control mice. We detected less Ki67 and proliferation cell nuclear antigen in paraffin sections from xenograft tumor specimens taken from α-pinene-treated mice than in those from the control group. Meanwhile, α-pinene treatment induced apoptosis in xenograft tumors as determined by the TUNEL assay. Conclusions: These data strongly suggest that α-pinene inhibits prostate cancer growth in a xenograft model and may be an effective therapeutic agent for prostate cancer treatment.

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